The protective role of resveratrol against zinc oxide induced nanotoxicity

Year 2017, , 21 - 25, 30.11.2017

Buğrahan Emsen , Hasan Türkez

https://doi.org/10.30616/ajb.343665

Cited By: 5

Abstract

Zinc oxide (ZnO) is a compound
that has harmful effects as well as being used in many different areas.
Numerous studies have been carried out to minimize the toxic effects of ZnO
nanoparticles (NPs). In the present study, the protective role of
resveratrol (RSV), a potent antioxidant polyphenol substance, was examined
against ZnO-induced nanotoxicity on human
pulmonary alveolar epithelial cells (HPAEpiC). In
this context, the cytotoxic and genotoxic effects of different concentrations
of RSV (5, 10, 20 mg/L) and ZnO NPs on the cells were measured alone
and in combination. At the same time, the effects of aforementioned
applications on the total antioxidant capacity (TAC) level in HPAEpiC were
assessed. The results obtained showed that ZnO NPs alone significantly
increased cytotoxicity and genotoxicity on cells compared to negative control
(control (-)). In the experiments performed with RSV + ZnO NP combination,
cytotoxic and genotoxic activity decreased at the level of p < 0.05 especially at 20 mg/L application of RSV. When
the level of TAC in cells was examined, a concentration-dependent increase was
detected between TAC and RSV. It was determined that Zno NPs reduced the TAC
level statistically (p
< 0.05) in comparison with control (-). In conclusion, the present study
revealed that RSV, a natural antioxidant, showed protective property against
genotoxic and cytotoxic damage induced by ZnO NPs on HPAEpiC.

Keywords

Antioxidant, Nanotoxicity, Resveratrol, Zinc oxide

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