Biofilm formation mechanism in fungi

Abstract

The biofilm problem is a problem that is commonly encountered in many areas of industry and causes serious economic losses. It is stated in the literature that biofilms can be removed from surfaces by appropriate cleaning methods. However, biofilm formation gains continuity over time. Biofilm studies are generally on bacteria. Microorganisms that cause infection in humans include bacteria, viruses, and fungi. In biofilm-borne infections, there may be only one or a combination of various microorganisms. Nowadays, new searches are in progress due to the ineffectiveness of synthetic drugs against fungal diseases, their side effects, and the increase of the number of pathogenic microorganisms that are rapidly resistant to existing antifungals. Therefore, the prevention of biofilm formation is now one of the most important studies worldwide.

Keywords

• Antifungal
• Biofilm
• Fungal Resistance

Mantarlarda biyofilm oluşum mekanizması

Abstract

Biyofilm sorunu endüstrinin birçok alanında yaygın olarak rastlanılan bir sorundur ve ciddi anlamda ekonomik kayıplara neden olmaktadır. Literatürde uygun temizleme yöntemleri ile biyofilmlerin yüzeylerden uzaklaştırılabileceği belirtilmektedir. Ancak zamanla biyofilm oluşumu süreklilik kazanır. Biyofilm çalışmalarının geneli bakteriler üzerinedir. İnsanlarda enfeksiyona neden olan mikroorganizmalar arasında bakteriler, virüsler ve funguslar bulunmaktadır. Biyofilm kaynaklı enfeksiyonlarda etken tek olabileceği gibi bazı mikroorganizmaların karışımıda olabilir. Günümüzde artan fungal hastalıklara karşı sentetik yapılı ilaçların yetersiz kalması, yan etkileri ve mevcut antifungallere hızla direnç kazanan patojen mikroorganizmaların sayısının artması ile yeni arayışlar devam etmektedir. Bütün bunlara bağlı olarak da biyofilm oluşumunun önlenmesi artık tüm dünyada önem arz eden çalışmaların başında gelmektedir.

Keywords

• Antifungal
• biyofilm
• fungal direnç

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