Bioactivities of Toxicodendron succedaneum (L.) Kuntze Extracts and Isolated Compounds

Abstract

Toxicodendron succedaneum (L.) Kuntze (synonym: Rhus succedanea L.) is a tree in the family of Anacardiaceae. T. succedaneum has been using to treat diarrhea, nose and gum bleedings, vomiting, dysentery, cough, tuberculosis, fever, asthma, liver ailments, and ear infections in traditional medicines. Phytochemicals such as agathisflavone, rhusflavone, robustaflavone, succedaneaflavanone, and volkensiflavone were isolated from this plant species. The purpose of this review is to analyze, summarize, and document available bioactivity studies of T. succedaneum. The Web of Science, Scopus, ScienceDirect, and PubMed (databases) were used to search relevant published papers between 1900 and November 2020. So far, in vivo is the highest level of scientific evidence available for the reported bioactivities. Various parts of T. succedaneum disclosed such as antibacterial, anticancer, anti-diabetic, anti-inflammatory, antioxidant, and antiviral activities. Anticancer, antioxidant, and antiviral compounds have been identified from this plant species. Further bioactivity and phytochemical studies should make it possible to obtain additional scientific evidence. This minireview work will be useful for future researches involving this plant species.

Keywords

• Toxicodendron succedaneum
• Rhus succedanea
• Anacardiaceae
• Sri Lanka
• Siddha Medicine
• bioactivities

References

1. [1] Kew Science, “Toxicodendron succedaneum (L.) Kuntze,” Plants of the World Online, 2020. http://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:71802-1 (accessed Nov. 29, 2020).
2. [2] C. P. Khare, “Rhus succedanea Linn.,” in Indian Medicinal Plants: An Illustrated Dictionary, New York, NY: Springer, 2007, pp. 1–1.
3. [3] S. K. Bhattacharjee, Handbook of Medicinal Plants, vol. 1. Jaipur: Pointer Publishers, 2004.
4. [4] A. V. S. Kottakkal, Indian Medicinal Plants. Andhra Pradesh: Orient Longman Ltd., 1995.
5. [5] M. Ortiz et al., “World Congress Integrative Medicine & Health 2017: part three,” BMC Complement Altern Med, vol. 17, no. 1, p. 333, 2017.
6. [6] S. V. Sathasivampillai, P. R. S. Rajamanoharan, M. Munday, and M. Heinrich, “Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources,” J Ethnopharmacol, vol. 198, pp. 531–599, 2017.
7. [7] S. V. Sathasivampillai, P. R. S. Rajamanoharan, and M. Heinrich, “Siddha Medicine in Eastern Sri Lanka Today–Continuity and Change in the Treatment of Diabetes,” Front. Pharmacol., vol. 9, 2018.
8. [8] S. V. Sathasivampillai, P. R. Rajamanoharan, M. Heinrich, and M. Munday, “Preparations and plants used to treat diabetes in Sri Lankan Siddha Medicine,” Colombo, Dec. 2015, vol. 3, p. 67.

9. [9] C. Fa-Ching, L. Yuh-Meei, and W. Jung-Chung, “Rhusflavone: A new flavanoflavone from Rhus succedanea,” Phytochemistry, vol. 13, no. 8, pp. 1571–1574, 1974.
10. [10] F.C. Chen and Y.M. Lin, “Rhusflavanone, a new biflavanone from the seeds of wax-tree,” J Chem Soc [Perkin 1], no. 1, pp. 98–101, 1976. [11] Y.M. Lin, F.C. Chen, and K. H. Lee, “Hinokiflavone, a cytotoxic principle from Rhus succedanea and the cytotoxicity of the related biflavonoids,” Planta Med, vol. 55, no. 2, pp. 166–168, 1989.
11. [12] M. Shimoda, Y. Wu, and Y. Osajima, “Aroma compounds from aqueous solution of haze (Rhus succedanea) honey determined by adsorptive column chromatography,” J Agric Food Chem, vol. 44, no. 12, pp. 3913–3918, 1996.
12. [13] J. R. Baheti, V. Kumar, G. B. Shah, and R. K. Goyal, “Free radical scavenging activity of aqueous extract of Rhus succedanea galls,” J Nat Remedies, vol. 5, no. 1, pp. 15–18, 2005.
13. [14] C.-P. Huang et al., “Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning,” Tox Appl Pharmacol, vol. 227, no. 3, pp. 331–338, 2008.
14. [15] H. H. Kim et al., “Antiproliferative effects of native plants on prostate cancer cells,” Nat Prod Sci, vol. 19, no. 2, pp. 192–200, 2013.
15. [16] V. Kumar, G. B. Shah, and N. S. Parmar, “Anti-inflammatory activity of aqueous extract of Rhus succedanea galls,” J Nat Remedies, vol. 3, no. 2, pp. 202–204, 2004.
16. [17] V. Kumar, T. Shah, G. B. Shah, and N. S. Parmar, “Anti-bacterial activity of Rhus succedanea galls,” J Nat Remedies, vol. 3, no. 1, pp. 95–96, 2003.
17. [18] Y.-M. Lee et al., “Screening of inhibitory effect on aldose reductase of Vietnam herbal medicines (II),” Korean J Pharmacogn, vol. 39, no. 4, pp. 324–329, 2008.
18. [19] Y.-M. Lin et al., “Antiviral activities of biflavonoids,” Planta Med, vol. 65, no. 2, pp. 120–125, 1999.
19. [20] Y. M. Lin et al., “Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro,” Bioorganic Med Chem Lett, vol. 7, no. 17, pp. 2325–2328, 1998.
20. [21] Y. M. Lin et al., “In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora,” J Nat Prod, vol. 60, no. 9, pp. 884–888, 1997.
21. [22] S. Shrestha, S. R. Subaramaihha, S. G. P. Subbaiah, R. S. B. Eshwarappa, and D. B. Lakkappa, “Evaluating the antimicrobial activity of methonolic extract of rhus succedanea leaf gall,” Bioimpacts, vol. 3, no. 4, pp. 195–198, 2013.
22. [23] S. Surveswaran, Y.-Z. Cai, H. Corke, and M. Sun, “Systematic evaluation of natural phenolic antioxidants from 133 Indian medicinal plants,” Food Chem, vol. 102, no. 3, pp. 938–953, 2007.
23. [24] P.-L. Wu, S.-B. Lin, C.-P. Huang, and R. Y.-Y. Chiou, “Antioxidative and cytotoxic compounds extracted from the sap of Rhus succedanea,” J Nat Prod, vol. 65, no. 11, pp. 1719–1721, 2002.
24. [25] D. E. Zembower, Y. M. Lin, M. T. Flavin, F. C. Chen, and B. E. Korba, “Robustaflavone, a potential non-nucleoside anti-hepatitis B agent,” Antiviral Res, vol. 39, no. 2, pp. 81–88, 1998.