Synthesis, Characterization and Antiviral Activities of Some Novel 4-Thiazolidinones Derived from Imidazo[2,1-b][1,3]thiazole-5-carbohydrazide Hydrazones

Year 2020, Volume: 1 Issue: 1, 22 - 30, 30.06.2020

Mine Isaoglu , Nesrin Cesur

Abstract

The present study describes the synthesis, characterization and antiviral activity evaluation of some novel 5-(nonsubstitue/methyl)-4-oxo-2-(substituted phenyl)-1,3-thiazolidine-4-one derivatives bearing an imidazo[2,1-b][1,3]thiazole-5-carboxamide moiety at N-3 position of the 4-thiazolidinone ring. The structures of the new 4-thiazolidinone compounds were confirmed by the data obtained from elemental analysis, IR, 1H-NMR, 13C-NMR (proton decoupled) and 13C-NMR (APT) spectra. The cytotoxicities and antiviral activities of 4-thiazolidinones were evaluated in-vitro against different types of DNA and RNA viruses in different cell cultures. Neither of the compounds had anti-influenza and anti-HIV activities, but 4c and 5d showed some degree of antiviral activity against the other tested virus types.

Keywords

Drug research, Carbonyl compounds, 4-Thiazolidinones, Hydrazide-hydrazones, Antiviral activity

Project Number

47045

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