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Year 2022, Volume: 3 Issue: 1, 18 - 24, 30.06.2022

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References

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Investigation of Antioxidant Efficacy of Glycyrrhiza glabra L. Extract in Glutamate Toxicity-Induced Primary Neuron Culture

Year 2022, Volume: 3 Issue: 1, 18 - 24, 30.06.2022

Abstract

Background: Glutamate toxicity and reactive oxygen accumulation are life-threatening factors that play a role in the pathogenesis of neurodegenerative diseases. Today, many studies are carried out to elucidate these pathological pathways and to reveal possible treatment possibilities. Herbal medicines have been used continuously by people since ancient times due to their low side effects and easy accessibility. Glycyrrhiza glabra L. extract is also one of the plants often used for medicinal purposes. Since the antioxidant activity of Glycyrrhiza glabra L. has been reported in the studies, its protective activity at different doses was investigated in primary neuron culture with glutamate toxicity.

Methodology/Main findings: In the experiment, which consisted of control, Glutamate Toxicity, GG 100 µg/ml, GG 200 µg/ml and GG 400 µg/ml experimental groups, primary neuron culture was performed and some tests were applied in order to test cell viability and antioxidant activity in this culture.These tests are superoxide dismutase, total antioxidant level, total oxidant level, malondialhedit level, lactate dehydrogenase activity and MTT (3-(4,5-dimethyltriazol-2-yl)-2,5-diphenyltetrazolium bromide) tests. Our GG 200 µg/ml treatment group had the most significant results in all tests in statistical studies. In all tests, the glutamate toxicity group was compared with the Control group, and the treatment groups were statistically compared with the glutamate toxicity group.

Conclusion: Significant results were obtained in the tests applied to determine the oxidative stress and cell viability caused by glutamate toxicity. In the study, it was shown that Glycyrrhiza glabra L. significantly reduced glutamate-induced cell death, LDH release, lipid peroxidation and oxidation in primary neuronal cells.

References

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  • P. Skehan et al., "New colorimetric cytotoxicity assay for anticancer-drug screening," JNCI: Journal of the National Cancer Institute, vol. 82, no. 13, pp. 1107-1112, 1990.
  • G. Pastorino, L. Cornara, S. Soares, F. Rodrigues, and M. B. P. Oliveira, "Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review," Phytotherapy research, vol. 32, no. 12, pp. 2323-2339, 2018.
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  • A. Hacımüftüoğlu, U. Okkay, M. Sağsöz, and M. Taşpınar, "DENEYSEL ALZHEİMER MODELİNDE HİPOKAMPÜSTE GLUTAMAT GERİ ALINIM PARAMETRELERİNİN DEĞERLENDİRİLMESİ," 2021.
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  • U. Okkay and I. F. Okkay, "Beneficial effects of linagliptin in cell culture model of Parkinson’s disease," The European Research Journal, vol. 8, no. 2, pp. 242-246, 2022.
  • U. Okkay and I. F. Okkay, "In vitro neuroprotective effects of allicin on Alzheimer’s disease model of neuroblastoma cell line," Journal of Surgery and Medicine, vol. 6, no. 2, pp. 209-212, 2022.
  • U. Okkay and I. F. Okkay, "Neuroprotective effect of nicorandil in 6-OHDA induced in vitro model of parkinson's disease," Medicine, vol. 11, no. 1, pp. 224-7, 2022.
  • B. Sadeghzadeh Oskouei, S. Zargari, P. Shahabi, M. Ghaffari Novin, and M. Pashaiasl, "Design and Microfabrication of An On-Chip Oocyte Maturation System for Reduction of Apoptosis," (in eng), Cell J, vol. 23, no. 1, pp. 32-39, 2021, doi: 10.22074/cellj.2021.7056.
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  • V. P. Kamboj, "Herbal medicine," Current science, vol. 78, no. 1, pp. 35-39, 2000.
  • D. Sharma, P. Namdeo, and P. Singh, "Phytochemistry & Pharmacological Studies of Glycyrrhiza glabra: A Medicinal Plant Review," Int. J. Pharm. Sci. Rev. Res., vol. 67, pp. 187-194, 2021.
  • G. E. Batiha, A. M. Beshbishy, D. S. Tayebwa, O. S. Adeyemi, N. Yokoyama, and I. Igarashi, "Evaluation of the inhibitory effect of ivermectin on the growth of Babesia and Theileria parasites in vitro and in vivo," (in eng), Trop Med Health, vol. 47, p. 42, 2019, doi: 10.1186/s41182-019-0171-8.
  • G. E.-S. BATIHA, A. M. BESHBISHY, D. S. TAYEBWA, H. M. SHAHEEN, N. YOKOYAMA, and I. IGARASHI, "Inhibitory effects of Uncaria tomentosa bark, Myrtus communis roots, Origanum vulgare leaves and Cuminum cyminum seeds extracts against the growth of Babesia and Theileria in vitro," Jpn. J. Vet. Parasitol. Vol, vol. 17, no. 1, 2018.
  • A. M. Beshbishy, G. E.-S. Batiha, O. S. Adeyemi, N. Yokoyama, and I. Igarashi, "Inhibitory effects of methanolic Olea europaea and acetonic Acacia laeta on growth of Babesia and Theileria," Asian Pacific Journal of Tropical Medicine, vol. 12, no. 9, p. 425, 2019.
  • D. M. Biondi, C. Rocco, and G. Ruberto, "New Dihydrostilbene Derivatives from the Leaves of Glycyrrhiza g labra and Evaluation of Their Antioxidant Activity," Journal of natural products, vol. 66, no. 4, pp. 477-480, 2003.
  • R. Isbrucker and G. Burdock, "Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin," Regulatory Toxicology and Pharmacology, vol. 46, no. 3, pp. 167-192, 2006.
  • J. Cinatl, B. Morgenstern, G. Bauer, P. Chandra, H. Rabenau, and H. Doerr, "Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus," The Lancet, vol. 361, no. 9374, pp. 2045-2046, 2003.
  • M. Ito et al., "Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)]," (in eng), Antiviral Res, vol. 7, no. 3, pp. 127-37, Mar 1987, doi: 10.1016/0166-3542(87)90001-5.
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  • H. Sato et al., "Therapeutic basis of glycyrrhizin on chronic hepatitis B," (in eng), Antiviral Res, vol. 30, no. 2-3, pp. 171-7, May 1996, doi: 10.1016/0166-3542(96)00942-4.
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There are 61 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Research Articles
Authors

Cemil Bayram 0000-0001-8940-8560

Ahmet Hacimuftuoglu 0000-0002-9658-3313

Publication Date June 30, 2022
Published in Issue Year 2022 Volume: 3 Issue: 1

Cite

EndNote Bayram C, Hacimuftuoglu A (June 1, 2022) Investigation of Antioxidant Efficacy of Glycyrrhiza glabra L. Extract in Glutamate Toxicity-Induced Primary Neuron Culture. Anatolian Journal of Biology 3 1 18–24.