MOLECULAR DOCKING STUDY OF LIPOFLAVONOIDS IN THE TREATMENT OF TINNITUS AGAINST THE EFFECTS OF COVID-19

Abstract

Background/aim:Treatment options are sought for coronavirus disease (COVID-19), which is a global health problem, and the demand for drugs that will eliminate or reduce the effects of SARS-CoV-2 is increasing day by day. The coronavirus disease leaves permanent effects and can even be fatal in patients with weakened immune systems. Considering this important factor, in this study, natural lipoflavonoid nutritional supplement, which is used both to strengthen the immune system and to treat tinnitus, smell and taste disorders, was chosen as the target drug. Materials and methods: Molecular docking analyzes of lipoflavonoid compounds were performed to understand the molecular interaction mechanisms between SARS-CoV-2, NMDAR and VKORC1 proteins. Results: In particular, the docking score of thiamine nitrate in NSP16 (-7.97 kcal/mol) and vitamin K epoxide reductase (-7.13 kcal/mol) was found to be high. Riboflavin's insertion score in K epoxide reductase (-8.66 kcal/mol) was also found to be high. Conclusion: These docking binding scores are indications that these compounds can be used as potential inhibitors. The hypothesis that the common symptoms of COVID-19, olfactory-taste disorder and tinnitus, can be treated in a short time and effectively with lipoflavonoids, and also that the replication of the coronavirus can be stopped, has been theoretically proven.

Keywords

• Lipo-Flavonoid compounds
• Tinnitus
• Bioflavonoids
• Covid-19 treatment

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