Role of Protein Oxidation, Lipid Peroxidation and Antioxidant Defense Systems on Diabetes Mellitus

Year 2018, Volume: 1 Issue: 1, 47 - 54, 30.09.2018

Serkan Sugeçti

Abstract

Abstract: Diabetes; is a chronic disease whose prevalence has been increasing day by day in the world. Several

mechanisms have been causing the formation of diabetes. One of these mechanisms is the oxidative stress that

occurs in cells and tissues. Oxidative damage which is caused by reactive oxygen species; has an important role

in the formation of complications due to diabetes. Hyperglycemia caused by diabetes increases free radical

formation. The antioxidant defense system tries to balance the toxic effects of reactive oxygen species. A, C, E

vitamins and glutathione is Non-enzymatic antioxidants, and superoxide dismutase, catalase, glutathione peroxidase

and glutathione reductase is enzymatic antioxidants against reactive oxygen species. In this study; the balance

between antioxidants and free radicals, the role of oxidative stress in diabetes and possible therapeutic effects

will be examined.

Keywords

Malondialdehyde, Oxidative damage, Free radicals, Antioxidant defense

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