Hematopoetik Kök Hücre Naklinde Tüm Vücut Işınlama
Öz
Tüm vücut ışınlama hematopoetik kök hücre nakli öncesi kemoterapi ile beraber hazırlık rejimi olarak lösemi, miyelodisplastik sendrom, aplastik anemi, multipl miyelom, lenfoma gibi birçok hastalığın tedavisinde kullanılmaktadır. Hazırlık rejiminin ana amacı alıcı kemik iliği ve olası rezidüel tümör hücrelerini eradike etmek, alıcının kemik iliğinde verici hematopoetik kök hücreleri için yer açmak ve allotransplant durumunda donör kök hücre reddini önlemek için immünsupresyon sağlamaktır.
Anahtar Kelimeler
Tüm vücut ışınlama, hematopoetik kök hücre nakli, hazırlık rejimi
References
- Roberts KB, Chen Z, Seropian S. Total-Body and Hemibody Irradiation. In Principles and Practice of Radiation Oncology, 5 th ed (Eds EC Halperin, CA. Perez, LW Brady):364-377. Philadelphia, Lippincott Williams &Wilkins. 2008.
- Young JYC, Schultheiss T. Radiotherapeutic principles of hematopoietic cell transplantation. In Thomas' Hematopoietic Cell Transplantation, 4th ed (Eds FR Appelbaum, SJ Forman, RS Negrin, KG Blume):333-350. West Sussex, UK, Wiley-Blackwell. 2009.
- Hartman AR, Williams SF, Dillon JJ. Survival, disease-free survival and adverse effects of conditioning for allogeneic bone marrow transplantation with busulfan/cyclophosphamide vs total body irradiation: a meta-analysis. Bone Marrow Transplant. 1998;22:439-43. Nevill TJ, Barnett MJ, Klingemann HG, Reece DE, Shepherd JD, Phillips GL. Regimen-related toxicity of a busulfan-cyclophosphamide conditioning regimen in 70 patients undergoing allogeneic bone marrow transplantation. J Clin Oncol. 1991;9:1224-32.
- Cosset JM, Socie G, Dubray B, Girinsky T, Fourquet A, Gluckman E. Single dose versus fractionated total body irradiation before bone marrow transplantation: radiobiological and clinical considerations. Int J Radiat Oncol Biol Phys. 1994;30:477-92.
- Devergie A, Blaise D, Attal M, Tigaud JD, Jouet JP, Vernant JP et al. Allogeneic bone marrow transplantation for chronic myeloid leukemia in first chronic phase: a randomized trial of busulfan-cytoxan versus cytoxan-total body irradiation as preparative regimen: a report from the French Society of Bone Marrow Graft (SFGM). Blood. 1995;85:2263-68.
- Socie G, Devergie A, Girinsky T, Reiffers J, Vernant JP, Le Bourgeois JP et al. Influence of the fractionation of total body irradiation on complications and relapse rate for chronic myelogenous leukemia. The Groupe d'Etude des greffes de moelle osseuse (GEGMO). Int J Radiat Oncol Biol Phys. 1991;20:397-404.
- Keane TJ, Van Dyk J. TBI schedules prior to bone marrow transplantation: requirements for comparison. Radiother Oncol. 1989;15:207-12.
- Scarpati D, Frassoni F, Vitale V, Corvo R, Franzone P, Barra S, et al. Total body irradiation in acute myeloid leukemia and chronic myelogenous leukemia: influence of dose and dose-rate on leukemia relapse. Int J Radiat Oncol Biol Phys. 1989;17:547-52.
