Hiperimmünglobülin D Sendromu
Abstract
Ateşli ataklar ile karakterize otoinflamatuvar sendromlar grubu hastalıklardan birisi de Hiperimmünglobülin D sendromu'dur. Moleküler genetiğin sağlamış olduğu olanaklar sayesinde, özellikle bu grup hastalıkların etiyopatogenezinin aydınlatılması kolaylaşmıştır. Hiperimmünglobülin D sendromu çok geniş yelpazeli klinik bulgularla seyredebilen bir hastalıktır. Her ne kadar Hiperimmünglobülin D sendromu tanılı hastaların çoğu Avrupa'dan ve özellikle de Felemenk ırktan olsalar da, pek çok farklı ülkeden bildirilmiş vakalar da vardır. Bu nedenle Hiperimmünglobülin D sendromu, periyodik ateş sendromlarının ayırıcı tanısında veya ailesel akdeniz ateşi hastalarını kolşisine dirençli kabul etmeden önce, akılda tutulması gereken bir hastalıktır.
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References
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