Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü

G.şeyda Seydel; Kıymet Aksoy

EN TR

Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü

Abstract

İmmun sisteminin bir parçası olan doğal öldürücü (Naturel Killer- NK) hücreler tümör hücrelerini ve virüs ile enfekte olmuş hücrelerini öldürebilme yeteneğine sahiptirler. NK hücrelerinin aktivasyonu aktive ve inhibe edici yüzey reseptörlerinin denge halinde olmasıyla düzenlenmektedir. Bu aktive edici reseptörlerden bir tanesi de NKG2D'dir. NKG2D'nin ligandları insan MHC lokusundan kodlanan sınıf I benzeri moleküller olan MICA ve MICB'dir. MICA ve MICB normal hücrelerden eksprese olmazlar fakat ısı şok ve viral enfeksiyon gibi stres koşulları altında ekspresyonları artar. Bu nedenle NKG2D ligandları stresin neden olduğu antijenler olarak tanımlanmaktadır.

Keywords

Doğal öldürücü hücreler, MICA/MICB, NKG2D reseptör

References

López-Larrea C, López-Soto A, González S. NK cell immune recognition: NKG2D ligands and stressed cells. Naturel Killer Cells. Bas Sci Cli App. 2010, 65-77.
Gruen JR, Weissman SM. Evolving views of the major histocompatibility complex. Blood.1997; 90:4252-4265.
Oğuz F, Karahan G, Özdilli K, et al. MHC and MIC genes Autoimmunity. Turk J Immunol. 2005;10:1-7.
Jamieson AM, Diefenbach A, McMahon CW, et al. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity. 2002;17:19-29.
Pende D, Cantoni C, Rivera P, et al. Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin. Eur J Immunol. 2001;31:1076-1086.
Bacon L, Eagle RA, Meyer M, et al. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. J Immunol. 2004;173:1078-1084.
Bahram S, Bresnahan M, Geraghty DE, et al. A second lineage of mammalian major histocompatibility complex class I genes. Proc Natl Acad Sci USA. 1994; 91: 6259-6263.
Ljunggren HG, Karre K. In search of the ‘missing self’: MHC molecules and NK cell recognition. Immunol Today. 1990;11: 237-244.
Oppenheim DE, Roberts SJ, Clarke SL, et al. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumour immunosurveillance. Nat Immunol. 2005;6:928-937.
Colombo MP, Trinchieri G. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 2002;13:155-168

Becknell B, Caligiuri MA. Interleukin-2, Interleukin-15, and their roles in human natural killer cells. Adv Immunol. 2005;86:209-239.
Lünemann A, Lünemann JD, Münz C. Regulatory NK-cell functions in inflammation and autoimmunity. Mol Med. 2009;15:352-358.
Bauer S, Groh V, Wu J, et al. Activation of NK cells and T cells by NKG2D, a receptor for stres inducible MICA. Science. 1999;285:727-729.
Raulet DH. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003;3:781-790.
Wu J, Song Y, Bakker AB, et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science.1999;285:730-732.
Petersdorf EW, Schuler KB, Longton GM, et al. Population study of allelic diversity in the human MHC class-I related MIC-A gene. Immunogenetics. 1999;49:605-612.
Stephens HA. MICA and MICB genes: can the enigma of their polymorphism be resolved. Trends Immunol. 2001;22:378-385.
Bahram S, Inoko H, Shiina T, et al. MIC and other NKG2D ligands: from none to too many. Curr Opin Immunol. 2005;17:505-509.
Yiğitbaştürk E. Türk populasyonunda yüksek rezolusyon MHC class-I related chain a (MICA) genotiplemesi, HLA-B – MICA haplotiplerinin incelenmesi ve yeni MICA alellerinin araştırılması. Doktora Tezi; Hacettepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Ankara,2006.
Zwirner NW, Fuertes MB, Giart MV, et al. Cytokine-driven regulation of NK cell functions in tumor immunity: Role of the MICA-NKG2D system. Cytokine Growth Fact. 2007;18:159-170.
Coudert JD, Held W. The role of the NKG2D receptor for tumor immunity. Sem Can Biol.
Tamaki S, Kawakami M, Ishitani A. Soluble MICB serum levels correlate with disease stage and survival rate in patients with oral squamous cell carcinoma. Anticancer Res. 2010;30:4097-4101.
Kahraman A, Schlattjan M, Kocabayoğlu P, et al. Major histocompatibility complex class I– related chains A and B (MIC A/B): A novel role in nonalcoholic steatohepatitis. Hepatology. 2010; 51:92-102.
Kohga K, Takehara T, Tatsumi T, et al. Serum levels of soluble major histocompatibility complex (MHC) classI-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma. Cancer Sci. 2008;99:1643-1649.
Duan X, Deng L, Chen X, et al. Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer. Med Oncol. 2010;10:9480-9489.
Gong WJ, Xiao WM, Gong CX, et al. Association of MICA gene polymorphism and serum soluble MICA level with colorectal cancer. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010;27:335-339.
Jınushi M, Takehara T, Tatsumi T, et al. Ekspression and role of MICA and MICB ın human hepatocellular carsinomas and their regulation by retinoic acid. Int J Cancer. 2003;104:354- 361.
Rui J, Long D, Wang W, et al. Valprole acid induce the Expression of MICA antigen in human lung cancer cells and promote the NK killing effects on the cells. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010; 41:10-14.
Boissel N, Rea D, Tieng V. BCR/ABL oncogene directly controls MHC class I chain-related molecule a expression in chronic myelogenous leukemia. J Immunol. 2006;176: 5108-5116.
http://www.rndsystems.com/mini_review_detail_objectname_MR02_NKG2D.aspx

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

G.şeyda Seydel

Kıymet Aksoy This is me

Publication Date

March 1, 2011

Submission Date

October 30, 2014

Acceptance Date

-

Published in Issue

Year 2011 Volume: 20 Number: 1

IZ

https://izlik.org/JA39RP56ME

APA

Seydel, G., & Aksoy, K. (2011). Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü. Arşiv Kaynak Tarama Dergisi, 20(1), 1-19. https://izlik.org/JA39RP56ME

AMA

1.Seydel G, Aksoy K. Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü. Arşiv Kaynak Tarama Dergisi. 2011;20(1):1-19. https://izlik.org/JA39RP56ME

Chicago

Seydel, G.şeyda, and Kıymet Aksoy. 2011. “Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü”. Arşiv Kaynak Tarama Dergisi 20 (1): 1-19. https://izlik.org/JA39RP56ME.

EndNote

Seydel G, Aksoy K (March 1, 2011) Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü. Arşiv Kaynak Tarama Dergisi 20 1 1–19.

IEEE

[1]G. Seydel and K. Aksoy, “Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü”, Arşiv Kaynak Tarama Dergisi, vol. 20, no. 1, pp. 1–19, Mar. 2011, [Online]. Available: https://izlik.org/JA39RP56ME

ISNAD

Seydel, G.şeyda - Aksoy, Kıymet. “Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü”. Arşiv Kaynak Tarama Dergisi 20/1 (March 1, 2011): 1-19. https://izlik.org/JA39RP56ME.

JAMA

1.Seydel G, Aksoy K. Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü. Arşiv Kaynak Tarama Dergisi. 2011;20:1–19.

MLA

Seydel, G.şeyda, and Kıymet Aksoy. “Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü”. Arşiv Kaynak Tarama Dergisi, vol. 20, no. 1, Mar. 2011, pp. 1-19, https://izlik.org/JA39RP56ME.

Vancouver

1.G.şeyda Seydel, Kıymet Aksoy. Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü. Arşiv Kaynak Tarama Dergisi [Internet]. 2011 Mar. 1;20(1):1-19. Available from: https://izlik.org/JA39RP56ME

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Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü

The Role of Stress-Induced Ligands in Immune Response

Abstract

Keywords

Stresle İndüklenen Ligandların İmmun Yanıttaki Rolü

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

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