Allogeneic Cord Blood Transplantation

Volume: 24 Number: 2 March 5, 2015
Banu Oflaz Sözmen , Mehmet Ertem
EN TR

Allogeneic Cord Blood Transplantation

Abstract

Allogeneic hematopoietic stem cell transplantation is an established treatment modality for many malignant and benign hematologic, metabolic and immunologic disorders. Cord blood has been used as an alternative to bone marrow and peripheral blood as the graft source. The clinical experience with cord blood transplantation has gradually increased both in pediatric and adult patient populations. So far double cord blood transplantation, in vitro expansion of cord blood unit and infusion of the cord blood into bone marrow space has been studied to expand the clinical applications of cord blood transplantation. The HLA match between the selected units as well as the patient, nucleated cell number of the transfused unit(s) have been shown to be most important in the unit selection.

Keywords

cord blood transplantation; hematopoietic stem cell transplantation; HLA

References

  1. Ballen KK, King RJ,Chitphakditi P, Bolan CD, Agora E, Hartzman RJ et al, The National Marrow Donor Program experience:the first 20 years of unrelated donor stem cell transplantation. Biol Blood Marrow Transplant. 2008;14:2-7
  2. Urbano-Ispizua A, Schmitz N, de Witte T, Frassoni F, Rosti G, Schrezenmeier H et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe. Bone Marrow Transplant. 2002;29:639-46.
  3. Çetin M, Ertem M. Çocukluk çağı hastalıklarında kemik iliği transplantasyonu endikasyonları. Katkı. 2002;23:540-50.
  4. Appelbaum FR. Pursuing the goal of a donor for everyone in need. N Eng J Med. 2012;367:1555- 6.
  5. Ballen KK, Gluckman E, Broxmeyer HE. Umbilical cord blood transplantation: the first 25 years and beyond. Blood. 2013;122:491-98.
  6. Knudtzon S. In vitro growth of granulocyte colonies from circulating cells in human cord blood. Blood. 1974;43:357-61.
  7. Gabutti V, Foa R, Mussa F, Aglietta M. Behavior of human hematopoietic stem cells in cord and neonatal blood. Haematologica. 1975;4:60-8.
  8. Wagner JE, Kurtzberg J. Allogeneic umbilical cord blood transplantation. In Cellular Characteristics of Cord Blood Transplantation (Ed HE Broxmeyer):113-45: Maryland, AABB Press Bethesda, 1998.
  9. Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D et al. Human umbilical cord blood as a source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci USA.
  10. Broxmeyer HE. The past, present, and future of cord blood transplantation. In:. Cellular Characteristics of Cord Blood Transplantation (Ed HE Broxmeyer):1-9. Maryland, AABB Press Bethesda, 1998.
AMA
1.Oflaz Sözmen B, Ertem M. Allogeneic Cord Blood Transplantation. Arşiv Kaynak Tarama Dergisi. 2015;24(2):195-210. doi:10.17827/aktd.06819