Pancreas-Bone-Testis Axis

Gülfidan Coşkun; Hülya Özgür; Sait Polat

doi:10.17827/aktd.85390

EN TR

Pancreas-Bone-Testis Axis

Abstract

Bone which has movement and support functions, is the largest organ of the body. Bone is regulated by hormonal signal but it also acts as an endocrine organ. Many peptide hormones such asosteocalcin are secreted from bone. Osteocalcin which is an osteoblast derived hormone, has two forms: “carboxylated (inactive) osteocalcin and decarboxylated (active) osteocalcin”. While inactive osteocalcin is found in bone matrix, active osteocalcin is given to blood circulation and acts as a multifunctional hormone. In the past ten years, numerous epidemiological, genetic and biochemical studies have revealed hormonal links between bone and pancreas, adipose tissue, gonads via active osteocalcin. In this review, a newly defined pathwaycalled pancreas-bone-testis axis which stimulates testosterone synthesis independent of hypothalamic hypophyseal testicular axis, is discussed.

Keywords

Pancreas, bone, testis, ınsulin, osteocalcin, testosterone

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Correspondence Address / Yazışma Adresi

Details

Primary Language

English

Subjects

-

Journal Section

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Authors

Gülfidan Coşkun This is me

Hülya Özgür This is me

Sait Polat This is me

Publication Date

September 14, 2015

Submission Date

September 14, 2015

Acceptance Date

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Published in Issue

Year 2015 Volume: 24 Number: 3

DOI

https://doi.org/10.17827/aktd.85390

IZ

https://izlik.org/JA38AT27FK

AMA

1.Coşkun G, Özgür H, Polat S. Pancreas-Bone-Testis Axis. Arşiv Kaynak Tarama Dergisi. 2015;24(3):355-367. doi:10.17827/aktd.85390

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European Journal of Environment and Public Health

https://doi.org/10.29333/ejeph/12799

This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Pancreas-Bone-Testis Axis

Pancreas-Bone-Testis Axis

Abstract

Keywords

Pankreas-Kemik-Testis Ekseni

Öz

Anahtar Kelimeler

References

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Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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Cited By

Protective and curative role of vitamin D and hormones on the cadmium-induced inhibition of proliferation of human osteoblast cells

Osteocalcin: A new phenomenon for type 2 diabetes and obesity