Role of NF-Kappa B in the Approach to Pancreatic Ductal Adenocarcinoma

Deniz Tuncel

doi:10.17827/aktd.31545

EN TR

Role of NF-Kappa B in the Approach to Pancreatic Ductal Adenocarcinoma

Abstract

Pancreatic ductal adenocarcinoma is now one of the most common causes of cancer death worldwide. K-ras mutations are present in up to 90% of pancreatic cancer cases. The expression of mutant K-ras activates the Akt/protein kinase B pathway, resulting in the activation of the nuclear factor-kappaB (NF-kB) transcriptional factor. Based on in vitro studies, constitutive NF-kB activity plays a key role in pancreatic carcinoma. NF-kB expression does not have direct effects on the overall survival of pancreatic ductal adenocarcinoma. The correlation with the positive lymph node status suggests a role in invasive properties of the tumor. Activation of NF-kB is most likely an early event in pancreatic carcinogenesis. Due to the increased activation in pancreatic cancer, NF-kB seems to be a good target for therapeutic interventions.

Keywords

Nuclear factor-kappaB, pancreas, adenocarcinoma

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Correspondence Address / Yazışma Adresi

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English

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Deniz Tuncel

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September 15, 2015

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September 15, 2015

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Year 2015 Volume: 24 Number: 4

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https://doi.org/10.17827/aktd.31545

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https://izlik.org/JA26TM32BU

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1.Tuncel D. Role of NF-Kappa B in the Approach to Pancreatic Ductal Adenocarcinoma. Arşiv Kaynak Tarama Dergisi. 2015;24(4):565-577. doi:10.17827/aktd.31545

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Role of NF-Kappa B in the Approach to Pancreatic Ductal Adenocarcinoma

Role of NF-Kappa B in the Approach to Pancreatic Ductal Adenocarcinoma

Abstract

Keywords

Pankreas Duktal Adenokarsinomuna Yaklaşımda NF-Kappa B’nin Rolü

Öz

Anahtar Kelimeler

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Published in Issue

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