Pediatric Intracerebral Tumors

Year 2014, Volume: 23 Issue: 3, 367 - 386, 30.10.2014

Ersin Hacıyakupoğlu Kadir Oktay Semih Kıvanç Olguner Mustafa Emre Saraç Derviş Mansuri Yılmaz Sebahattin Hacıyakupoğlu

https://doi.org/10.17827/aktd.15184

Abstract

Histopathology, appearance, biological behaviour, cytogenesis, molecular biology, physiology and effects on the brain development of the pediatric intracerebral tumors are completely different from the tumours in adults. In adults, glioblastoma multiforme and meningiomas are seen mostly, but in children pilocytic astrocytoma, medulloblastoma and germ cell tumours are more common. When pediatric intracerebral tumours are detected, families should be supported and the physcosocial trauma affecting the family should be reduced. As pediatric intracranial tumours are located mostly in the midline, neurological symptoms of them are quite faint. As cerebrospinal fluid paths are obstructed, increased intracranial pressure symptoms appear. Special anesthetic and surgical techniques should be performed for children. Stereotactic surgery, neuroendoscopy, functional and intraoperative magnetic resonance imaging and neuromonitoring could be used. Radiotherapy (in patients aged 3 and more years old), stereotactic radiosurgery, chemotherapy and gene therapies could be performed as the other treatment modalities.

Keywords

Pediatric intracerebral tumors, Stereotactic radiosurgery, Alpha-phetoprotein, Human chorionic gonadotropin, Radiotherapy, Chemotherapy

Çocukluk Çağı Beyin Tümörleri

Abstract

Çocukluk çağı beyin tümörleri erişkinlerden histopatolojisi, görünümü, biyolojik davranışı , sitogenezi, moleküller biyolojisi, fizyolojisi ve beyin gelişiminin etkilenmesi yönünden oldukça farklıdırlar. Erişkinlerde glioblastoma multiforme ve menengioma sık görülürken, çocuklarda pilositik astrositoma, medulloblastoma ve germ hücreli tümörlere daha sık rastlanır. Çocukluk çağı tümörleri orta hatta yerleştiklerinden nörolojik bulguları oldukça siliktir. Ancak beyin omurilik sıvı yolları tıkanıklığında intrakranial basınç artışı bulguları ortaya çıkar. Çocuklar için özel anestezi ve cerrahi teknikler kullanılmalıdır. Operasyonda stereotaktik cerrahi, nöroendoskopi, fonksiyonel ve intraoperatif manyetik rezonans görüntüleme ve nöromonitorizasyon kullanılır. Operasyon dışında radyoterapi (3 yaşından büyük çocuklarda), stereotaktik radyocerrahi, kemoterapi ve gen tedavileri uygulanabilir.

Keywords

Çocukluk çağı beyin tümörleri, Stereotaktik radyocerrahi, Alfa-fetoprotein, Human koryonik gonatropin, Radyoterapi, Kemoterapi

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