Abstract
Folate is a vital B vitamin which is easily water-soluble. It is a natural source which is found in the herbal and animal foods. Folate has important duties in the human metabolism, one of them is the adjustment of the level of plasma homocysteine. Reduction in MTHFR (methylenetetrahydrofolate reductase),which is in charge of the metabolism of homocysteine activity affects the level of homocysteine. Therefore MTHFR is an important enzyme in folate metabolism. Some of the mutations occurring in the MTHFR gene is a risk factor for various diseases and may be caused the hyperhomocysteinemia or the homocystinuria, and they also may lead to metabolic problems. MTHFR is effective in the important pathways such as DNA synthesis, methylation reactions and synthesis of RNA. C677T and A1298C are the most commonly occurring polymorphisms in the gene of MTHFR. The frequency of these polymorphisms show differences in the populations. MTHFR, folate distribution, metabolism of homocysteine and S-adenosylmethionine, by the MTHFR methylation the genetic defects have the potential of affecting the risk of disease in the negative or positive way.
Keywords
References
- Clarok WG, Brater IDC, Johnson AR. Antianemic drugs. In: Goth's Medical Pharmacology. St.Louis: CV Mosby Company, 1988: 3-612.
- Günaydın MF. Demans hastalarında homosistein, vitamin B12 ve folat ilişkisi (Tıpta uzmanlık tezi). İstanbul, S.B. İstanbul Eğitim ve Araştırma Hastanesi, 2008.
- Ratanasthien K, Blair JA, Leeming RJ, Cooke WT, Melikian V. Serum folates in man. J Clin Path. 1977; 30:438–48.
- Stokstad ELR, Koch J. Folic acid metabolism. Physiol Rev. 1967; 47:82–116.
- Butterworth CE, Santini R, Frohmeyer WB. The pteroylglutamate components of American diets as determined by chromatographic fractionation. J Clin Invest. 1963; 42:1929–39.
Abstract
Folat, suda çözünebilen önemli bir B vitaminidir. Bitkisel ve hayvansal kaynaklı gıdalarda doğal olarak bulunmaktadır. Folat, metabolizmada önemli görevler üstlenmektedir. Bunlardan biri de plazma homosistein düzeyinin ayarlanmasıdır. Homosistein metabolizmasında görevli olan MTHFR (Metilentetrahidrofolat redüktaz) aktivitesinde azalma, homosistein seviyesini etkilemektedir. Bu nedenle MTHFR folat metabolizmasında önemli bir enzimdir. MTHFR geninde meydana gelen bazı mutasyonlar çeşitli hastalıklar için risk faktörü olan hiperhomosisteinemi ve homosisteinüriye sebep olabilmekte, metabolik sorunlara yol açabilmektedir. MTHFR, DNA sentezi, metilasyon reaksiyonları ve RNA sentezi gibi önemli yolaklarda etkilidir. MTHFR geninde meydana gelen en yaygın polimorfizmler C677T ve A1298C' dir. Bu polimorfizmlerin sıklığı populasyonlarda farklılık göstermektedir. MTHFR, folat dağılımını, homosistein metabolizmasını ve S-adenosilmetionin vasıtasıyla metilasyonu etkilediği için MTHFR' de genetik kusurlar hastalık riskini negatif ve pozitif olarak ayarlama potansiyeline sahiptir.
Keywords
References
- Clarok WG, Brater IDC, Johnson AR. Antianemic drugs. In: Goth's Medical Pharmacology. St.Louis: CV Mosby Company, 1988: 3-612.
- Günaydın MF. Demans hastalarında homosistein, vitamin B12 ve folat ilişkisi (Tıpta uzmanlık tezi). İstanbul, S.B. İstanbul Eğitim ve Araştırma Hastanesi, 2008.
- Ratanasthien K, Blair JA, Leeming RJ, Cooke WT, Melikian V. Serum folates in man. J Clin Path. 1977; 30:438–48.
- Stokstad ELR, Koch J. Folic acid metabolism. Physiol Rev. 1967; 47:82–116.
- Butterworth CE, Santini R, Frohmeyer WB. The pteroylglutamate components of American diets as determined by chromatographic fractionation. J Clin Invest. 1963; 42:1929–39.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Review |
| Authors | |
| Publication Date | October 30, 2014 |
| Published in Issue | Year 2014 Volume: 23 Issue: 2 |
Cited By
Altered methyltetrahydrofolate reductase gene polymorphism in mothers of children with attention deficit and hyperactivity disorder
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Saliha Baykal
https://doi.org/10.1016/j.pnpbp.2018.07.020
