Obstructive Sleep Apnea Syndrome

Year 2012, Volume: 21 Issue: 2, 134 - 150, 01.06.2012

Ahmet Turan Evlice

Abstract

Obstructive sleep apnea syndrome is characterized by repeated airway collapse during sleep. The syndrome affects adult men more common than women. The most frequent and characteristic nocturnal symptom is snoring, the most important daytime symptom is sleepiness. The social, neuropsychological and cardiovascular consequences of obstructive sleep apnea syndrome cause severe morbidity and mortality. Early diagnosis and treatment of this disease may reduce mortality and morbidity due to cardiovascular causes.

Keywords

Obstructive sleep apnea syndrome, symptom, treatment

Obstrüktif Uyku Apne Sendromu

Abstract

Obstrüktif uyku apne sendromu; uyku sırasında üst hava yolunun tekrarlayan tıkanmaları ile seyreden bir klinik tablodur. Erişkin yaştaki erkeklerde kadınlardan daha sık görülür. En sık rastlanan gece semptomu horlama, gündüz semptomu aşırı uykululuk halidir. Obstrüktif uyku apne sendromu sosyal ve nöropsikolojik sonuçlarının yanı sıra kardiyovasküler sonuçlarıyla da ciddi morbidite ve mortaliteye neden olan hastalıklardan biridir. Bu hastalığın erken tanı ve tedavisi, kardiovasküler nedenlere bağlı mortalite ve morbiditeyi azaltacaktır.

Keywords

Obstrüktif uyku apne sendromu, semptom, tedavi

References

• Mayer P, Dematteis M, Pépin JL, Wuyam B, Veale D, Vila A, Lévy P. Peripheral neuropathy in sleep apnea. A tissue marker of the severity of nocturnal desaturation. Am J Respir Crit Care Med. 1999; 159: 213-9.
• Lüdemann P, Dziewas R, Sörös P, Happe S, Frese A. Axonal polyneuropathy in obstructive
• sleep apnoea. J Neurol Neurosurg Psychiatry. 2001; 70: 685-7.
• Dziewas R, Schilling M, Engel P, Boentert M, Hor H, Okegwo A et al. Treatment for obstructive sleep apnoea: effect on peripheral nerve function. J Neurol Neurosurg Psychiatry. 2007; 78: 295-7.
• American Academy of SleepMedicine. The AASM Manual for the Scoring of Sleep and Associated Events. 2007; 17-31.
• Flanigan WF, Wilcox RH, Rechtschaffen A. The EEG and behavioral continuum of the crocodilian, Caiman sclerops. Electroencephalogr Clin Neurophysiol. 1973; 34: 521-38.
• Schulz H. Phasic or transient? Comment on the terminology of the AASM manual for the scoring of sleep and associated events. J Clin Sleep Med. 2007; 3: 752.
• Karadag M. Dünyada ve Türkiyede uyku çalışmaları. Akciğer Arşivi. 2007; 8: 62-4.
• Bickelmann AG, Burwell CS, Robin ED, Whaley RD. Extreme obesity associated with alveolar hypoventilation; a Pickwickian syndrome. Am J Med. 1956; 21: 811-8.
• Duchna HW. [Sleep-related breathing disorders--a second edition of the International Classification of Sleep Disorders (ICSD-2) of the American Academy of Sleep Medicine (AASM)]. Pneumologie. 2006; 60: 568-75.
• Gould GA, Whyte KF, Rhind GB, Airlie MA, Catterall JR, Shapiro CM, Douglas NJ. The sleep hypopnea syndrome. Am Rev Respir Dis. 1988; 137: 895-8.
• Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep. 1999; 22: 667-89.
• Patil SP, Schneider H, Schwartz AR, Smith PL. Adult obstructive sleep apnea: pathophysiology and diagnosis. Chest. 2007; 132: 325-37.
• Banno K, Kryger MH. Sleep apnea: clinical investigations in humans. Sleep Med. 2007; 8: 400-26.
• Bondemark LH. Does 2 years' nocturnal treatment with a mandibular advancement splint in adult patients with snoring and OSAS cause a change in the posture of the mandible? Am J Orthod Dentofacial Orthop. 1999; 116: 621-8.
• Can M, Açikgöz S, Mungan G, Bayraktaroğlu T, Koçak E, Güven B, Demirtas S. Serum
• cardiovascular risk factors in obstructive sleep apnea. Chest. 2006; 129: 233-7.
• Tsuiki S, Almeida FR, Lowe AA, Su J, Fleetham JA. The interaction between changes in upright mandibular position and supine airway size in patients with obstructive sleep apnea. Am J Orthod Dentofacial Orthop. 2005; 128: 504-12.
• Hoekema A, Stegenga B, De Bont LG. Efficacy and co-morbidity of oral appliances in the treatment of obstructive sleep apnea-hypopnea: a systematic review. Crit Rev Oral Biol Med. 2004; 15: 137-55.
• Guilleminault C, Quera-Salva MA, Partinen M, Jamieson A. Women and the obstructive sleep apnea syndrome. Chest. 1988; 93: 104-9.
• Manber R, Armitage R. Sex, steroids, and sleep: a review. Sleep. 1999; 22: 540-55.
• Strollo PJ, Rogers RM. Obstructive sleep apnea. N Engl J Med. 1996; 334: 99-104.
• Strohl KP, Saunders NA, Feldman NT, Hallett M. Obstructive sleep apnea in family members. N Engl J Med. 1978; 299: 969-73.
• Redline S, Tishler PV, Tosteson TD, Williamson J, Kump K, Browner I, Ferrette V, Krejci P. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med. 1995; 151: 682-7.
• Guilleminault C, Partinen M, Hollman K, Powell N, Stoohs R. Familial aggregates in obstructive sleep apnea syndrome. Chest. 1995; 107: 1545-51.
• Redline S, Tishler PV, Hans MG, Tosteson TD, Strohl KP, Spry K. Racial differences in sleep-disordered breathing in African-Americans and Caucasians. Am J Respir Crit Care Med. 1997; 155: 186-92.
• Ong KC, Clerk AA. Comparison of the severity of sleep-disordered breathing in Asian and Caucasian patients seen at a sleep disorders center. Respir Med. 1998; 92: 843-8.
• Heimer D, Scharf SM, Lieberman A, Lavie P. Sleep apnea syndrome treated by repair of deviated nasal septum. Chest. 1983; 84: 184-5.
• Mangat D, Orr WC, Smith RO. Sleep apnea, hypersomnolence, and upper airway obstruction secondary to adenotonsillar enlargement. Arch Otolaryngol. 1977;103:383-6.
• Cartwright RD, Diaz F, Lloyd S. The effects of sleep posture and sleep stage on apnea frequency. Sleep. 1991; 14: 351-3.
• Grunstein RR, Ho KY, Sullivan CE. Sleep apnea in acromegaly. Ann Intern Med. 1991. 115: 527-32.
• Rajagopal KR, Abbrecht PH, Derderian SS, Pickett C, Hofeldt F, Tellis CJ, Zwillich CW. Obstructive sleep apnea in hypothyroidism. Ann Intern Med. 1984; 101: 491-4.
• Findley LJ, Bonnie RJ. Sleep apnea and auto crashes. What is the doctor to do? Chest. 1988; 94: 225-6.
• Aldrich MS. Automobile accidents in patients with sleep disorders. Sleep, 1989; 12: 487-94.
• Haraldsson PO, Carenfelt C, Diderichsen F, Nygren A, Tingvall C. Clinical symptoms of sleep apnea syndrome and automobile accidents. ORL J Otorhinolaryngol Relat Spec. 1990; 52: 57-62.
• Olson LG, King MT, Hensley MJ, Saunders NA. A community study of snoring and sleep- disordered breathing. Health outcomes. Am J Respir Crit Care Med. 1995; 152: 717-20.
• Strobel RJ, Rosen RC. Obesity and weight loss in obstructive sleep apnea: a critical review. Sleep. 1996; 19: 104-15.
• Lyle D. Obstructive Sleep Apnea, . American Family Physician. 1999; 60: 2279-86.
• Almeida FR, Lowe AA, Sung JO, Tsuiki S, Otsuka R. Long-term sequellae of oral appliance therapy in obstructive sleep apnea patients: Part 1. Cephalometric analysis. Am J Orthod Dentofacial Orthop. 2006; 129: 195-204.
• Battagel JM, Johal A, Kotecha B. A cephalometric comparison of subjects with snoring and obstructive sleep apnoea. Eur J Orthod. 2000; 22: 353-65.
• Battagel JM, L'Estrange PR, Nolan P, Harkness B. The role of lateral cephalometric radiography and fluoroscopy in assessing mandibular advancement in sleep-related disorders. Eur J Orthod. 1998; 20: 121-32.
• Kyung SH, Park YC, Pae EK. Obstructive sleep apnea patients with the oral appliance experience pharyngeal size and shape changes in three dimensions. Angle Orthod. 2005; 75: 15-22.
• Pomeranz B, Macaulay RJ, Caudill MA, Kutz I, Adam D, Gordon D, Kilborn KM, Barger AC, Shannon DC, Cohen RJ et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol. 1985; 151-3.
• Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res. 1986; 59: 178-93.
• Sullivan CE, Issa FG, Berthon-Jones M, Eves L. Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet. 1981; 1:862-5.
• Hoffstein V, Zamel N, Phillipson EA. Lung volume dependence of pharyngeal cross- sectional area in patients with obstructive sleep apnea. Am Rev Respir Dis. 1984. 130: 175- 8.
• Loube DI, Gay PC, Strohl KP, Pack AI, White DP, Collop NA. Indications for positive airway pressure treatment of adult obstructive sleep apnea patients: a consensus statement. Chest. 1999; 115: 863-6.
• Anon. Practice parameters for treatment of OSA in adults. Sleep. 1997; 20: 406-22.
• Engleman HM, Cheshire KE, Deary IJ, Douglas NJ. Daytime sleepiness, cognitive performance and mood after continuous positive airway pressure for the sleep apnoea/hypopnoea syndrome. Thorax. 1993; 48: 911-4.
• Faccenda JF, Mackay TW, Boon NA, Douglas NJ. Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome. Am J Respir Crit Care Med. 2001; 163: 344-8.
• Phillips BG, Somers VK. Neural and humoral mechanisms mediating cardiovascular responses to obstructive sleep apnea. Respir Physiol. 2000; 119: 181-7.
• Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest. 1995; 96: 1897-904.
• Narkiewicz K, Kato M, Phillips BG, Pesek CA, Davison DE, Somers VK. Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea. Circulation. 1999; 100: 2332-5.
• Waradekar NV, Sinoway LI, Zwillich CW, Leuenberger UA. Influence of treatment on muscle sympathetic nerve activity in sleep apnea. Am J Respir Crit Care Med,.1996; 153: 1333-8.