Cellular Signaling Pathways and Their Clinical Reflections

Year 2010, Volume: 19 Issue: 3, 180 - 191, 01.09.2010

N. Ceren Sümer-turanlıgil Dr.yiğit Uyanıkgil

Abstract

Cellular signaling pathways have important roles in cellular growth, differentiation, inflammatory response and apoptosis and in regulation of cellular responses under various chemical stimulators. Different proteins which belong to these pathways may be exposed to loss-of-function or gain-of-function mutations; this may lead to many clinical phenotypes including primarily cancer. In this review information about basic working principles of these pathways and diseases related to them are included.

Keywords

Signal transduction, G proteins, cAMP, phospholipase C, NF-kB, MAP Kinase, Ca++, JAK-STAT.

Hücre İçi Sinyal Yolakları ve Klinik Yansımaları

Abstract

…………………….180 Dok. Öğr. N. Ceren SÜMER-TURANLIGİL, Dr.Yiğit UYANIKGİL Hücre içi sinyal yolakları hücresel büyüme, farklılaşma, enflamatuar yanıt, apoptoz gibi süreçlerde ve çeşitli kimyasal uyaranlar karşısında hücrelerin verdikleri yanıtları düzenlemede önemli rol oynarlar. Yolaklarda yer alan çeşitli proteinlerin işlev kazandırıcı veya işlev kaybettirici mutasyonlara uğraması, kanser başta olmak üzere çok farklı klinik tablolara yol açabilir. Bu derlemede bu yolakların temel çalışma prensipleri ve ilişkili hastalıklar hakkında genel bilgiler yer almaktadır. Anahtar Kelimeler:

Keywords

Sinyal iletimi, G proteinleri, cAMP, Fosfolipaz C, NF-kB, MAP Kinaz, Ca++, JAK-STAT

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