Abstract
Ion channels especially nicotinic acethylcholine receptor channels, potassium and sodium channels play roles in the physiopathology of various types of epilepsies. They play vital roles in either providing membrane potential and in neuronal signaling. In this review, first, information about the structure and function of ion channels and then how the structure and functions of subunits of them change within a neurological disease like epilepsy will be given.
Keywords
References
- Kullmann DM, Hanna MG. Neurological disorders caused by inherited ion-channel mutations. Lancet Neurology 2002, 1: 157-166. .
- Celesia GG . Disorders of membrane channels or channelopathies. Clinical Neurophysiology 2001, 112; 2-18.
- Weinreich F, Jentsch TJ. Neurological diseases caused by ion channel mutations. Current Opinion in Neurobiology 2000, 10: 409-415.
- Lerche H, Jurkat-Rott K, Horn FL. Ion channels and epilepsy. American Journal of Medical genetics 2001, 106: 146-159.
- Olive F. Metabotropic glutamate receptor ligands as potential theurapeutics for addiction. Current Drug Abuse Review 2009, 2(1): 83-989.
- Lehmann-Horn F, Jurkatt-Rott K. Voltage gated ion channels and hereditary disease. Physiological Reviews 1999, 79(4): 1317-1372.
Abstract
Epilepsinin çeşitli türlerinin fizyopatolojisinde başta nikotinik asetilkolin reseptörü kanalı, potasyum ve sodyum kanalları olmak üzere çeşitli iyon kanalları rol almaktadır. İyon kanalları gerek membran potansiyelinin gerekse nöronal haberleşmenin sağlanmasında yaşamsal öneme sahiptir. Bu derlemede önce iyon kanallarının işlevleri ve sınıflandırılması hakkında bilgi verilecek, ardından da nörolojik bir hastalık olan epilepside iyon kanal alt birimlerinin yapı ve işlevinin nasıl değiştiğine değinilecektir.
Keywords
References
- Kullmann DM, Hanna MG. Neurological disorders caused by inherited ion-channel mutations. Lancet Neurology 2002, 1: 157-166. .
- Celesia GG . Disorders of membrane channels or channelopathies. Clinical Neurophysiology 2001, 112; 2-18.
- Weinreich F, Jentsch TJ. Neurological diseases caused by ion channel mutations. Current Opinion in Neurobiology 2000, 10: 409-415.
- Lerche H, Jurkat-Rott K, Horn FL. Ion channels and epilepsy. American Journal of Medical genetics 2001, 106: 146-159.
- Olive F. Metabotropic glutamate receptor ligands as potential theurapeutics for addiction. Current Drug Abuse Review 2009, 2(1): 83-989.
- Lehmann-Horn F, Jurkatt-Rott K. Voltage gated ion channels and hereditary disease. Physiological Reviews 1999, 79(4): 1317-1372.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Review |
| Authors | |
| Publication Date | June 1, 2010 |
| Published in Issue | Year 2010 Volume: 19 Issue: 2 |
