Abstract
The circadian clock controls the daily rhythmicity of the biochemistry, physiology, and behavior of the organisms. Disruption of circadian rhythms, affects many biological processes within the body and results in different long-term diseases, such as cancer. Circadian regulatory pathways causes rhythmic epigenetic modifications and the formation of circadian epigenomes. Abnormal epigenetic modifications, such as hypermethylation, may be involved in the transformation of normal cells into cancer cells. In this review, some of the circadian genes and regulatory proteins, the current evidence related to the epigenetic modifications that result in circadian disruption and he carcinogenic effects of circadian disruption and its potential role in different human cancers using an epigenetic viewpoint will be reviewed.
Keywords
References
- 1. Dunlap J. Molecular bases for circadian clocks, Cell Journal, 1999;96:271-90.
- 2. Zhang RY, Mou LJ, Li XM, Li XW, Qin Y. Temporally Relationship between Renal Local Clock System and Circadian Rhythm of the Water Electrolyte Excretion. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015;37:698-704.
- 3. Axelrod S, Saez L, Young MW. Studying circadian rhythm and sleep using genetic screens in Drosophila. Methods Enzymol. 2015;551:3-27.
- 4. Forni D, Pozzoli U, Cagliani R, Tresoldi C, Menozzi G. Genetic adaptation of the human circadian clock to day-length latitudinal variations and relevance for affective disorders. Genome Biol 2014;15:499.
- 5. Imaizumi T, Kay SA. Photoperiodic control of flowering: not only by coincidence, Trends in Plant Science. 2006;11:550-8.
Abstract
Sirkadiyen saat organizmaların biyokimyalarının, fizyolojilerinin ve davranışlarının günlük ritmlerini kontrol eder. Sirkadiyen ritmin bozulması, kanserler de dahil olmak üzere birçok uzun süreli hastalığı ve vücuttaki biyolojik süreçleri etkilemektedir. Sirkadiyen düzenleyici yollar, sirkadiyen epigenomların oluşumuna ve ritmik epigenetik değişikliklere neden olur. Sirkadiyenin bozulmasından dolayı oluşan hipermetilasyon gibi anormal epigenetik modifikasyonlar, normal hücrelerin kanser hücrelerine dönüşümüne sebep olabilir. Bu derlemede sirkadiyen genler ve düzenleyici proteinler, sirkadiyen saatin bozulması sonucu oluşan epigenetik değişikliklere ilişkin güncel kanıtlar ve sirkadiyen bozulmanın karsinojenik etkileri ve insanlardaki farklı kanserlerdeki potansiyel rolü tartışılacaktır.
Keywords
References
- 1. Dunlap J. Molecular bases for circadian clocks, Cell Journal, 1999;96:271-90.
- 2. Zhang RY, Mou LJ, Li XM, Li XW, Qin Y. Temporally Relationship between Renal Local Clock System and Circadian Rhythm of the Water Electrolyte Excretion. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015;37:698-704.
- 3. Axelrod S, Saez L, Young MW. Studying circadian rhythm and sleep using genetic screens in Drosophila. Methods Enzymol. 2015;551:3-27.
- 4. Forni D, Pozzoli U, Cagliani R, Tresoldi C, Menozzi G. Genetic adaptation of the human circadian clock to day-length latitudinal variations and relevance for affective disorders. Genome Biol 2014;15:499.
- 5. Imaizumi T, Kay SA. Photoperiodic control of flowering: not only by coincidence, Trends in Plant Science. 2006;11:550-8.
Details
| Subjects | Health Care Administration |
|---|---|
| Journal Section | Review |
| Authors | |
| Publication Date | March 31, 2017 |
| Acceptance Date | July 28, 2016 |
| Published in Issue | Year 2017 Volume: 26 Issue: 1 |
