Voltage-Gated Calcium Channels and Molecular Features

Yıl 2018, Cilt: 27 Sayı: 1, 1 - 17, 31.03.2018

Mustafa Emre

https://doi.org/10.17827/aktd.329803

Cited By: 1

Öz

Electrobiophysical records obtained from cells such as neuron, muscle and endocrine have revealed that there are calcium (Ca2+) currents with distinctive characteristics which can be activated by voltage. Calcium channels have been categorized as low voltage-activated Ca2+ channels (LVA), low-threshold calcium channels and high-voltage activated calcium channels (HVA), high-threshold calcium channels in terms of calcium channels activation. Voltage-gated calcium channels have been classified with respect to their activation and inactivation kinetics, ion characteristics, the permeability and their sensitivity to drug and the toxin. Voltage-dependent calcium channels have different distributions in the tissues and show different characteristics in different tissues. In this review, the available information about voltage-gated calcium channels have been summarized. 

Anahtar Kelimeler

Calcium channels, subfamilies

Voltaj Kapılı Kalsiyum Kanalları ve Moleküller Özellikleri

Öz

Nöron, kas ve endokrin gibi hücrelerden elde edilen elektrobiyofizik kayıtlar, belirgin karakteristiklere sahip ve voltajla aktive edilebilen kalsiyum (Ca2+) akımların olduğunu ortaya koymuştur. Kalsiyum kanalları aktivasyon durumlarına göre düşük voltajla aktive olan (LVA), düşük eşikli kalsiyum kanallar ve yüksek voltajla aktive olan (HVA), yüksek eşikli kalsiyum kanalları olarak kategorize edilmiştir. Voltaj kapılı kalsiyum kanalları; aktivasyon ve inaktivasyon kinetiklerine, iyon özelliklerine, geçirgenliklerine, ilaç ve toksinlere olan duyarlıklarına göre sınıflandırılmışlar. Voltaj bağımlı kalsiyum kanalların dokulardaki dağılımları farklı olup, değişik dokularda değişik karekteristikler gösterirler. Bu derlemede, voltaj kapılı kalsiyum kanallarıyla ilgili mevcut bilgiler özetlenmiştir. 

Anahtar Kelimeler

Kalsiyum kanalları, altaile

Kaynakça

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