Tamoksifen Kullanan Hastaların Jinekolojik Yönden Değerlendirilmesi

Year 2021, Volume: 30 Issue: 1, 45 - 51, 31.03.2021

Ümran Küçükgöz Güleç Semra Paydaş Ahmet Barış Güzel

https://doi.org/10.17827/aktd.899315

Abstract

Meme kanseri dünyada ve ülkemizde kadınlarda en sık görülen kanserdir. Diğer malign tümörlerde olduğu gibi meme kanserli kadınların takibi de multidisipliner yaklaşım gerektirir. Meme kanserlerinin %70 kadarı hormon duyarlıdır. Tamoksifen hormon reseptörü pozitif meme kanserli olguların hem adjuvan amaçlı hem de metastatik dönemde endokrin tedavilerinde hem pre-menopozal hem de post-menopozal dönemde etkili non-steroid selektif östrojen reseptör modülatörüdür (SERM). Dünyada en fazla kullanılan anti-kanser ilaç olan tamoksifenin diğer yan etkilerinin yanısıra önemli jinekolojik yan etkilere yol açabilir. Tamoksifen bazı benign jinekolojik patolojileri artırmakla kalmaz endometrial karsinom başta olmak üzere sarkom, karsinosarkom gibi bi-fazik malignansilerin de görülme sıklığını artırır.
Tamoksifen kullanan veya kullanmış bir kadının jinekolojik açıdan takibindeki önemli noktalar bu derlemenin amacıdır.

Keywords

Meme Kanseri, Tamoksifen, jinekolojik Değerlendirme

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