Bağırsak-Beyin Eksenine Biyokimyasal Bakış

Year 2021, Volume: 30 Issue: 3, 137 - 143, 30.09.2021

Ümmühan Fulden Aydın , Abdullah Tuli

https://doi.org/10.17827/aktd.910674

Cited By: 1

Abstract

Bağırsak mikrobiyatası ve beyin birbiriyle çift yönlü iletişimde olan iki sistemdir. Çift yönlü bu iletişim bağırsak mikrobiyatasının beyinden etkilenmesini içerdiği kadar bağırsak mikrobiyatasının da beyni etkilemesi anlamına gelmektedir. Güncel veriler bu iletişimin biyokimyasal, immünolojik ve nörolojik yollarını gözler önüne serer. Bağırsak mikrobiyatasının gelişimi, bütünlüğü ve içeriği konağın metabolizması üzerinde oldukça etkindir. Bu derlemede bağırsak mikrobiyatasının konak metabolizmasına olan etkileri ve bağırsak mikrobiyatası-beyin ekseni biyokimyasal bakış açısıyla değerlendirilmiştir.

Keywords

Bağırsak mikrobiyatası, Bağırsak-Beyin Ekseni, Konak metabolizması

Biochemical Perspective of the Gut-Brain Axis

Abstract

The gut microbiota and the brain are two systems in bidirectional communication. It is desired that the intestinal microbiota affects the brain as much as this bidirectional intestinal microbiota is affected by the brain. Current data reveal the biochemical, immunological, and neurological pathways of this communication. It is highly effective on the development and integrity of the gut microbiota and the metabolism of the transferred host. In this review, the effects of intestinal microbiota on host metabolism and intestinal microbiota-brain axis were evaluated from a biochemical perspective.

Keywords

Gut microbiota, gut-brain axis, host metabolism

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