Şizofrenide Epigenetik Bakış Açısı: DNA Metilasyon Modelleri

Year 2022, Volume: 31 Issue: 3, 204 - 212, 30.09.2022

Ezgi Karaaslan Şükrü Kartalcı Ceren Acar

https://doi.org/10.17827/aktd.1096901

Cited By: 1

Abstract

Şizofreni, sanrılar, halüsinasyonlar ve çeşitli davranış bozuklukları ile karakterize bir zihinsel bozukluktur. Dünya nüfusunun yaklaşık %1'ini etkileyen şizofreni sadece hastaları değil toplumun diğer üyelerini de etkilemektedir. Hastalığın etiyolojisinde genetik ve çevresel faktörler rol oynamaktadır.
Genetik, nörogelişimsel bozukluklar, ilaç kullanımı, şehir hayatı, tek başına veya birlikte hastalığa neden olan faktörler sayılabilir. Son yıllarda artan araştırmalara rağmen şizofreni oluşumuna neden olan faktörler tam olarak aydınlatılamamıştır ve daha fazla araştırmaya ihtiyaç vardır. Genetik faktörlerin şizofreni için risk faktörleri olmasına rağmen, bazı çevresel faktörlerin hastalığın ortaya çıkışını etkilediği düşünülmektedir. Epigenetik mekanizmalar, DNA'nın nükleotid dizisini değiştirmeden gen fonksiyonlarını düzenler. DNA metilasyonu şizofreni ile ilişkilidir ve birçok şizofreni aday geninde metilasyon durumu çalışmaları yapılmıştır. DNA metilasyon durumlarının incelenmesi psikiyatrik araştırmalara önemli katkı sağlayacaktır.
Bu derlemede şizofreni ile ilgili DNA metilasyon çalışmalarından elde edilen global veri tabanlarında yayınlanan veriler özetlenmiş ve şizofrenideki önemi kısaca tartışılmıştır.

Keywords

şizofreni, epigenetik, çevresel faktörler, DNA metilasyonu

Supporting Institution

İnönü Üniversitesi

Project Number

FYL-2020-2241

Thanks

Yazarlar desteklerinden dolayı İnönü Üniversitesi Bilimsel Araştırma Projeleri Birimi'ne teşekkür etmektedirler.

Epigenetic Perspective in Schizophrenia: DNA Methylation Patterns

Abstract

Schizophrenia is a mental disorder characterized by delusions, hallucinations and various behavioral disorders. Affecting approximately 1% of the world's population, schizophrenia not only affects patients, but also other members of the society. Genetic and environmental factors play roles in the etiology of the disorder.
Genetics, neurodevelopmental disorder, drug use, urban life, alone or together can be counted as the factors that cause the disorder. Despite increasing studies in recent years, the factors causing the formation of schizophrenia have not been fully clarified and more research is needed. Although genetic factors are risk factors for schizophrenia, it is thought that some environmental factors affect the emergence of the disorder. Epigenetic mechanisms regulate gene functions without changing the nucleotide sequence of DNA. DNA methylation is associated with schizophrenia, and methylation status studies have been conducted in many schizophrenia candidate genes. Examination of DNA methylation states will contribute significantly to psychiatric research.
In this review, data published in global databases obtained from DNA methylation studies related with schizophrenia are summarized and their importance in schizophrenia is briefly discussed.

Keywords

schizophrenia, epigenetics, environmental factors, DNA methylation

Project Number

FYL-2020-2241

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