Antihipertansif İlaçlar ve Teratojenite Alanında Güncel Araştırmalar

Year 2023, Volume: 32 Issue: 2, 61 - 67, 30.06.2023

Duygun Altıntaş Aykan

https://doi.org/10.17827/aktd.1237593

Abstract

Gebelikte hipertansif bozukluklar, dünya çapında gebeliklerin en yaygın tıbbi komplikasyonlarındandır. Gebelik sırasında hipertansiyonu tedavi etme kararı, hem anne hem de fetüs için riskleri ve yararları göz önünde bulundurularak alınmalıdır. Hipertansiyon tedavisinin amacı maternal riski azaltmak olsa da, seçilen ajanlar fetüs için güvenli olmalıdır. Uzun vadeli prognoz, tahmini maternal risk ve beklenen fetal sonuçlar multidisipliner bir yönetim planı oluşturularak hasta ile paylaşılmalıdır. Bu çalışmada, gebelik sırasında hipertansiyon tedavisine ilişkin kılavuzlar, antihipertansif ilaçların gebelikte maruziyeti ile ilgili hayvan çalışmaları ve insan gebelik raporları incelenmiştir. Antihipertansif ilaçların gebelikte kullanımının güvenliliği ve oluşabilecek potansiyel teratojenik etkileri derlenmiştir.

Keywords

Teratojenite, hipertansiyon, antihipertansif ajanlar, gebelik

Supporting Institution

Yok

CURRENT RESEARCH IN THE FIELD OF ANTIHYPERTENSIVE DRUGS AND TERATOGENICITY

Abstract

Hypertensive disorders in pregnancy are among the most common medical complications of pregnancies worldwide. The decision to treat hypertension during pregnancy should be made considering the risks and benefits for both mother and fetus. Although the goal of hypertension treatment is to reduce the maternal risk, the agents chosen should be safe for the fetus. Long-term prognosis, estimated maternal risk, and expected fetal outcomes should be shared with the patient by a multidisciplinary management plan. In this study, the guidelines for the treatment of hypertension during pregnancy, the animal studies involving exposure to the antihypertensive drugs during pregnancy, and human pregnancy reports were examined. The safety and potential teratogenic effects of antihypertensive drugs during pregnancy have been reviewed.

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