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X Kromozomu İnaktivasyonu ve İnaktivasyondan Kaçış

Yıl 2023, Cilt: 32 Sayı: 3, 180 - 187, 30.09.2023
https://doi.org/10.17827/aktd.1319050

Öz

X kromozomunun inaktivasyonu dişi memelilerde iki tane olan X kromozomlarından bir tanesinin inaktive edilmesidir. İnaktivasyona uğrayacak X kromozomu, heterokromatin şeklinde paketlenmektedir. Böylece bu X kromozomunun üzerindeki genlerin eksprese edilmeleri önlenmektedir. İnaktivasyon işlemi, bir adet X kromozomu bulunan erkekler ile iki adet X kromozomu bulunan dişiler arasındaki dengeyi sağlamaktadır. X kromozomu inaktivasyonu, inaktive edilecek tüm X kromozomunda gerçekleştiği düşünülse de, X kromozomunun üzerindeki genlerin tamamı inaktivasyona maruz kalmayıp bir kısmı inaktivasyondan kaçmaktadır. İnsanlarda X kromozomundan kodlanan genlerin yaklaşık %12 ile 20'si kadarı inaktivasyon işleminden kaçarak eksprese olabilmektedir. Derlemede, X inaktivasyonunun mekanizmaları ele alınarak, aktivasyon sürecini ve aktivasyondan kaçan genleri inceleyeceğiz.

Kaynakça

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Toplam 47 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Derleme
Yazarlar

Başak Günaştı 0000-0003-3068-0652

Erken Görünüm Tarihi 27 Eylül 2023
Yayımlanma Tarihi 30 Eylül 2023
Kabul Tarihi 1 Eylül 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 32 Sayı: 3

Kaynak Göster

AMA Günaştı B. X Kromozomu İnaktivasyonu ve İnaktivasyondan Kaçış. aktd. Eylül 2023;32(3):180-187. doi:10.17827/aktd.1319050