Adalimumab associated lupus like syndrome in the patients with Crohn disease

Year 2020, Volume: 2 Issue: 4, 149 - 151, 23.09.2020

Güray Can , Fatime Demir , Müjgan Gürler , Meral Akdoğan Kayhan

Abstract

Crohn’s disease is a systemic, autoimmune disease affected whole the gastrointestinal system. hastalığı tüm gastrointestinal sistemi tutan sistemik otoimmun bir hastalıktır. Drug-associated autoimmune diseases such as lupus-like syndrome are going to be seen related to antiTNF-alpha that is used frequently. This case is the Crohn’s disease that acut pancreatitis has developed after the usage of azathioprine, and then adalimumab has been started, lupus-like syndrome related to adalimumab has emerged. A little part of these side effects are related to autoimmunity. This autoimmunity is associated with the increase of Th2 cytokine response, and as a result, the production of autoantibody. Drug-associated lupus is the situation that is reversible after the stopping causative agent. It must be keep in mind that drug-associated lupus-like syndrome can emerge in the patients used antiTNF-alpha.

Keywords

Adalimumab, Crohn’s disease, lupus-like syndrome

Crohn tanılı hastada adalimumab ilişkili lupus benzeri sendrom

Abstract

Crohn hastalığı tüm gastrointestinal sistemi tutan sistemik otoimmun bir hastalıktır. Sıklıkla kullanılan antiTNF-alfa’ya bağlı ilaç ilişkili lupus gibi otoimmun hastalıklar gözlenmektedir. Vakamız, azathioprin ile akut pankreatit gelişen ve sonrasında adalimumab’a geçilen, adalimumab kullanımı sonrası lupus benzeri sendrom gelişen Crohn hastasıdır. Bu yan etkilerin bir kısmı otoimmunite ile ilgili olup Th2 sitokin yanıtının artışı ve sonucunda otoantikor üretimi ile ilişkilidir. İlaç ilişkili lupus, suçlu ilacın kesilmesiyle klinik bulguların geri dönebildiği bir durumdur. antiTNF-alfa kullanan hastalarda gelişebileceği akılda tutulmalıdır.

Keywords

Adalimumab, Crohn hastalığı, lupus benzeri sendrom

References

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