Side Effect of Lamotrigine in the Emergency Department; Stevens-Johnson Syndrome

Year 2022, , 31 - 33, 09.03.2022

Sinan Eliaçık

https://doi.org/10.54996/anatolianjem.1015618

Abstract

Aim: Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) is a life-threatening mucocutaneous skin reaction that usually develops against drugs, although there are various factors in its etiology. In this case report, SJS due to antiepileptic drug use will be briefly reviewed.

Case:20-year-old female patient was seen in the emergency department with a generalized tonic-clonic seizure. With the detailed anamnesis and laboratory findings obtained, the patient was started lamothyrigine therapy. While the dose was titrated in the treatment, treatment was stopped in the patient who developed SJS, and a new antiepileptic drug was started.

Conclusion: SJS/TEN is the same disease spectrum with different severity. They are classified according to the percentage of skin detachment area. The pathogenesis of SJS/TEN is still unclear and optimal treatment options are still controversial.

Keywords

Stevens Johnson Syndrome, toxic epidermel necrolysis, lamotirigine

Acil Servise Lamotrijinin Yan Etkisi ile Başvuru; Stevens Johnson Sendromu

Abstract

Amaç: Stevens Johnson Sendromu ve Toksik Epidermal Nekroliz (SJS/TEN), hayatı tehdit edebilen, etiyolojisinde çeşitli faktörler olmakla birlikte genellikle ilaçlara karşı gelişen mukokutanöz cilt reaksiyonudur. Bu vaka sunumu ile anti-epileptik ilaç kullanımına bağlı gelişen SJS kısaca gözden geçirilecektir.

Olgu: 20 yaşında kadın hasta jeneralize tonik klonik nöbet ile acil serviste görüldü. Alınan ayrıntılı anamnez ve laboratuvar bulguları ile hastaya lamotirijin tedavisi başlandı. Tedavide doz titre edilirken SJS gelişen hastada tedavi kesilerek yeni anti-epileptik ilaç başlandı.

Sonuç: SJS/TEN farklı şiddette olan aynı hastalık spektrumudur. Cilt dekolmanı alanının yüzdesine göre sınıflanırlar. SJS/TEN’in patogenezi hala belirsizdir ve optimal tedavi seçenekleri tartışmalıdır. Etiyolojide sıkça ilaçlar sorumlu tutulmaktadır.

Keywords

Stevens Johnson sendromu, toksik epidermal nekroliz, lamotirijin

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