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Addison’s Crisis or Momordica Charantia Extract: Which Caused Shock?

Year 2023, Volume: 6 Issue: 3, 134 - 136, 30.09.2023
https://doi.org/10.54996/anatolianjem.1197292

Abstract

Aim: Addison’s crisis is extremely rare entity that is difficult to diagnose in the emergency department. Here we present a case of Addison’s crisis diagnosed in the emergency department who complained of vomiting after consuming extract of Momordica charantia fruit for gastric pain.

Case: A 29-year-old female was admitted to the emergency department with complaints of nausea and vomiting after consuming Momordica charantia extract for stomach pain. The patient had tachypnea, tachycardia, hypoglycemia, and hypotension. Blood tests revealed elevated anion gap (24 mEq/L) metabolic acidosis, +4 acetone, normokalemia, and hyponatremia. Although it was impossible to exclude intoxication immediately, 100 mg hydrocortisone was given IV due to possible Addison’s crisis after obtaining blood samples for hormone testing and excluding other causes of shock. The tests revealed very high ACTH (1.250 pg/mL) and low cortisol (1.23 ug/dL) levels, and the patient was diagnosed with primary adrenal insufficiency.

Conclusion: This case illustrates the importance of comprehensive examination and management of profound hypotension and hypoglycemia in the emergency department and of emergency physicians diagnosing and initiating appropriate treatment for Addison’s crisis.

References

  • Giwa A. Primary Adrenal Failure in the Emergency Department. Am J Emerg Med. 2018;36(2):340.e3-340.e5. doi:10.1016/J.AJEM.2017.10.043
  • Betterle C, Presotto F, Furmaniak J. Epidemiology, pathogenesis, and diagnosis of Addison’ s disease in adults. Journal of Endocrinological Investigation 2019 42:12. 2019;42(12):1407-1433. doi:10.1007/S40618-019-01079-6
  • Rathbun KM, Nguyen M, Singhal M. Addisonian Crisis. Emerg Med (N Y). 2022;4(3):151-152. doi:10.1111/j.1442-2026.1992.tb00075.x
  • Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis. 2013;3(2):93-102. doi:10.1016/S2222-1808(13)60052-3
  • Dineen R, Thompson CJ, Sherlock M. Adrenal crisis: prevention and management in adult patients. Ther Adv Endocrinol Metab. 2019;10. doi:10.1177/2042018819848218/ASSET/IMAGES/LARGE/10.1177_2042018819848218-FIG1.JPEG

Şokun Sebebi Addison Krizi mi Yoksa Kudret Narı (Momordica charantia) mı?

Year 2023, Volume: 6 Issue: 3, 134 - 136, 30.09.2023
https://doi.org/10.54996/anatolianjem.1197292

Abstract

Amaç: Addison krizi acil serviste tanı konulması zor olan oldukça nadir rastlanan bir durumdur. Bu yazımızda acil servise mide ağrısı için kudret narı meyvesi (Momordica charantia) ekstresi yedikten sonra kusma şikâyeti ilen başvurup, addison krizi tanısı konulan olguyu sunmayı hedefledik.

Olgu: 29 yaşında kadın hasta mide ağrısı için kudret narı (Momordica charantia) meyvesi ekstresini yedikten sonra bulantı ve kusma şikayetiyle acil servise başvurdu. Hastanın başvuru anında takipne, taşikardi, hipoglisemi ve hipotansiyonu mevcuttu. Kan sonuçlarında anyon açıklığı artmış (24 mEq/L) metabolik asidoz, +4 aseton, normokalemi ve hiponatremi görüldü. Zehirlenmeyi hemen dışlamak mümkün olmadığı için olası Addison krizi nedeniyle hormon testi için kan örneği alındıktan sonra ve diğer şok nedenleri dışlanarak IV 100 mg hidrokortizon verildi. Daha sonra hastanın kan sonuçlarında çok yüksek ACTH düzeyi (1.250 pg/mL) ve düşük kortizol (1.23 ug/dL) düzeyi tespit edildi ve hastaya primer adrenal yetmezlik tanısı konuldu.

Sonuç: Bu vaka, acil serviste derin hipotansiyon ve hipogliseminin kapsamlı muayenesinin ve yönetiminin, Addison krizini teşhis eden ve uygun tedaviyi başlatan acil hekimlerinin önemini göstermektedir.

References

  • Giwa A. Primary Adrenal Failure in the Emergency Department. Am J Emerg Med. 2018;36(2):340.e3-340.e5. doi:10.1016/J.AJEM.2017.10.043
  • Betterle C, Presotto F, Furmaniak J. Epidemiology, pathogenesis, and diagnosis of Addison’ s disease in adults. Journal of Endocrinological Investigation 2019 42:12. 2019;42(12):1407-1433. doi:10.1007/S40618-019-01079-6
  • Rathbun KM, Nguyen M, Singhal M. Addisonian Crisis. Emerg Med (N Y). 2022;4(3):151-152. doi:10.1111/j.1442-2026.1992.tb00075.x
  • Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis. 2013;3(2):93-102. doi:10.1016/S2222-1808(13)60052-3
  • Dineen R, Thompson CJ, Sherlock M. Adrenal crisis: prevention and management in adult patients. Ther Adv Endocrinol Metab. 2019;10. doi:10.1177/2042018819848218/ASSET/IMAGES/LARGE/10.1177_2042018819848218-FIG1.JPEG
There are 5 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

Rana Dişel 0000-0003-2381-3066

Ömer Taşkın 0000-0003-0517-8484

Mehtap Evran 0000-0002-1796-3845

Ufuk Akday 0000-0001-7878-1773

Ayça Açıkalın 0000-0002-1259-3398

Publication Date September 30, 2023
Published in Issue Year 2023 Volume: 6 Issue: 3

Cite

AMA Dişel R, Taşkın Ö, Evran M, Akday U, Açıkalın A. Addison’s Crisis or Momordica Charantia Extract: Which Caused Shock?. Anatolian J Emerg Med. September 2023;6(3):134-136. doi:10.54996/anatolianjem.1197292