Kırım Kongo Kanamalı Ateşi Hastalarının Prognozunda Sistemik İnflamasyon Yanıt İndeksinin (SIRI) Öngörücü Rolü

Year 2025, Volume: 8 Issue: 3, 101 - 106, 30.09.2025

Şimşek Çelik , Yusuf Kenan Tekin , İlhan Korkmaz , Sefa Yurtbay , İsmail Kıvanç Cebecioğlu

https://doi.org/10.54996/anatolianjem.1545907

Abstract

Amaç: Acil servislere başvuran Kırım Kongo Kanamalı Ateşi (KKKA) hastalarında Sistemik İnflamasyon Yanıt İndeksi'nin (SIRI) mortaliteyi öngörmedeki gücünün belirlenmesi amaçlanmıştır.
Gereç ve Yöntemler: Ocak 2012-Aralık 2022 tarihleri arasında acil servise başvuran 1140 hasta çalışmaya dahil edildi. Demografik veriler, nötrofil-lenfosit oranı (NLR), sistemik immün-inflamasyon indeksi (SIII), agregat sistemik inflamasyon indeksi (AISI) ve sistemik inflamasyon yanıt indeksi (SIRI) kaydedildi. Frekans verileri Ki-kare testi ile analiz edilirken, ordinal veriler Mann Whitney U testi ile analiz edilmiştir. Ölüm riskini öngören faktörleri belirlemek için receiver operating characteristic (ROC) analizi yapılmıştır.
Bulgular: Ölümcül seyreden KKKA hastalarında NLR ve SİRİ değerleri anlamlı derecede yüksek bulunmuştur. SIRI için 0,77 en uygun eşik değeri 89% duyarlılık ve 90% özgüllük, NLR için 3,42 eşik değeri ise 88% duyarlılık ve 89% özgüllük göstermiştir.
Sonuç: Sistemik inflamasyon yanıt indeksi, mortaliteyi öngörme gücü ve mortalite üzerindeki etkisi açısından en yüksek duyarlılık ve özgüllük düzeylerine sahiptir. Sistemik inflamasyon yanıt indeksi acil servislerde Kırım Kongo Kanamalı Ateşi hastalarında mortaliteyi öngörmek için kullanılabilir.

Keywords

AISI , Kırım Kongo Kanamalı Ateşi , mortalite , NLR , SIRI

The Predictive Role of Systemic Inflammation Response Index (SIRI) in the Prognosis of Crimean-Congo Hemorrhagic Fever Patients

Abstract

Aim: The objective was to determine the strength of the Systemic Inflammation Response Index (SIRI) in the prediction of mortality in Crimean Congo Hemorrhagic Fever (CCHF) patients who applied to emergency department.
Material and Methods: One thousand one hundred forty patients who applied to emergency department between January 2012 and December 2022 were included in the study. Demographical data, the neutrophile-lymphocyte ratio (NLR), the systemic immune-inflammation index (SIII), the aggregate index of systemic inflammation (AISI), and the systemic inflammation response index (SIRI) were recorded. Frequency data was analyzed with the Chi-square test while ordinal data was analysed with the Mann Whitney U test. The receiver operating characteristic (ROC) analysis was conducted to determine the predictive factors of the risk of death.
Results: The NLR and SIRI values were found to be significantly higher in CCHF patients observed to be fatal. An optimal cut-off value of 0.77 with 89% sensitivity and 90% specificity for SIRI, a cut-off value of 3.42 with 88% sensitivity and 89% specificity for NLR, were demonstrated.
Conclusion: The systemic inflammation response index has the highest sensitivity and specificity levels in terms of mortality prediction strength and the impact on mortality. The systemic inflammation response index could be sued to predict mortality for Crimean Congo Hemorrhagic Fever patients in emergency services.

Keywords

AISI , Crimean Congo Hemorrahagic Fever , mortality , NLR , SIRI

Ethical Statement

This retrospective study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the Ethics Council (Date: 22/02/2023; No: 2023-02/18).

Thanks

We would like to thank the archive and information technology personnel who contributed to the collection of study data.

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