Otizm ve mitokondriyal fonksiyon bozukluğu (DÜZELTME: Bu makalenin özet bölümü düzeltilmiştir)

Year 2022, Volume: 3 Issue: 3, 95 - 99, 29.12.2022

Rukiye Arslan

Abstract

Otizm spektrum bozukluğu (OSB); tekrarlayan davranışlar, sınırlı ilgi alanı, dil becerilerinde yetersizlik, sosyal iletişim ve etkileşimde bozulma ile karakterize nörogelişimsel bir bozukluktur. Yaygınlığı gün geçtikçe artan OSB’ye neyin neden olduğu tam olarak bilinmemekle birlikte OSB’nin bir dizi çevre ve gen etkileşiminden kaynaklandığı belirtilmektedir. Çevresel faktörlere karşı aşırı derecede savunmasız olan mitokondrinin son yıllarda yapılan bazı çalışmalara göre OSB’li çocuklarda atipik bir gelişim sergilediği tespit edilmiştir. Birçok hücresel işlevde yer alan ve çok yönlü bir organel olan mitokondrinin OSB ile arasında bir ilişki olduğu söylenmektedir. Bu nedenle bu derlemede, otizm spektrum bozukluğu ve mitokondriyal fonksiyon bozuklukları arasındaki ilişki ele alınmıştır.

Keywords

mitokondri, mitokondriyal disfonksiyon, otizm

Autism and mitochondrial dysfunction (CORRECTION: The abstract of this article has been corrected)

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behaviors, limited interest field, inadequacy in language skills, and impaired social communication and interaction. Although it is not known exactly what causes ASD, the prevalence of which is increasing day by day, yet it is stated that ASD is caused by a series of environmental and genetic interactions. It has been determined that mitochondria, which are extremely vulnerable to environmental factors, exhibit an atypical development in children with ASD according to some studies conducted in recent years. It is said that mitochondria, which is a versatile organelle involved in many cellular functions, has a relationship with ASD. Therefore, in this review, the relationship between autism spectrum disorder and mitochondrial dysfunction is studied.

Keywords

mitochondria, mitochondrial dysfunction, autism

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