Reflex influences on oropharyngeal swallowing

Abstract

Swallowing is a complex sensorimotor behaviour involving the coordinated and reflex contraction and inhibition of the musculature located in and around the mouth, larynx, pharynx and esophagus. Voluntary swallowing is under the the control of the cerebral cortex and other subcortical structures, but the main locations are the nucleus tractus solitarius and nucleus ambiguus, and their neural network of central pattern generator. In spite of these central controls, there are some intrinsic reflex actions between three phases of swallowing. These kind of reflexes were emphasized in this review. 

Keywords

• central pattern generator
• larynx
• pharynx
• protective reflexes
• swallowing

References

1. Miller AJ. Deglutition. Physiol Rev 1982;62:129–84.
2. Thexton AJ, Crompton AW. The control of swallowing. In:
3. Linden RWA, ed. Frontiers of Oral Biology. Basel: Karger; 1998;
4. p. 168–222.
5. Jean A. Brainstem control of swallowing: neuronal network and
6. cellular mechanisms. Physiol Rev 2001;81:929–69.
7. Ertekin C, Aydogdu I. Neurophysiology of swallowing. Clin
8. Neurophysiol 2003;114:2226–44.

9. Lear CSC, Flanagan JBJ, Moorrees CFA. The frequency of deglutition
10. in man. Arch Oral Biol 1965;10:83–99.
11. Calloway S, Fonagy D, Pounder R. Frequency of swallowing in
12. duodenal ulceration and hiatus hernia. Br Med J 1982;285:23–4.
13. Kapila YV, Doddo WJ, Helm JF, Hogan WJ. Relationship between
14. swallow rate and salivary flow. Dig Dis Sci 1984;29:528–33.
15. Lagerlöf F, Dawes C. The volume of saliva in the mouth before
16. and after swallowing. J Dent Res 1984;63:618–21.
17. Pehlivan M, Yüceyar N, Ertekin C, Celebi G, Ertafl M, Kalayci T,
18. Aydo¤du I. An electronic device measuring the frequency of spontaneous
19. swallowing: digital phagometer. Dysphagia 1996;11:259–64.
20. Rudney JD, Larson CJ. The prediction of saliva swallowing frequency
21. in humans from estimates of salivary flow rate and the volume
22. of saliva swallowed. Arch Oral Biol 1995;40:507–12.
23. Ertekin C. Voluntary versus spontaneous swallowing in man.
24. Dysphagia 2011;26:183–92.
25. Ertekin C, Kiylioglu N, Tarlaci S, Turman AB, Secil Y, Aydogdu
26. I. Voluntary and reflex influences on the initiation of swallowing
27. reflex in man. Dysphagia 2001;16:40–7.
28. Miller JL, Sonies BC, Macedonia C. Emergence of oropharyngeal,
29. laryngeal and swallowing activity in the developing fetal upper
30. aerodigestive tract: an ultrasound evaluation. Early Hum Dev 2003;
31. :61–87.
32. Poleg D, Goldman JA. Fetal deglutition: a study of the anencephalic
33. fetus. Eur J Obstet Gynecol Reprod Biol 1978;8:133–6.
34. Pritchard JA. Deglutition by normal and anencephalic fetus. J Obstet
35. Gynecol 1965; 25:289–97.
36. Martin, RE Neuroplasticity and swallowing. Dysphagia 2009;24:
37. –29.
38. Nishino T. Swallowing as a protective reflex for the upper respiratory
39. tract. Anesthesiology 1993;79:588–601.
40. Shaker R, Ren J, Zamir Z, Sarna S, Liv J, Sui Z. Effect of aging,
41. position and temperature on the threshold volume triggering pharyngeal
42. swallows. 1994;107:396–402.
43. Doty RW, Bosma JF. An electromyographic analysis of reflex deglutition.
44. J Neurophysiol 1956;19:44–60.
45. Thexton AJ, Crompton AW, German RZ. Electromyographic
46. activity during the reflex pharyngeal swallow in the pig: Doty and
47. Bosma (1956) revisited. J Appl Physiol 2007;102:587–600.
48. Dodds WJ, Hogan WJ, Reid DP, Stewart ET, Arndorfer RC. A
49. comparison between primary esophageal peristalsis following wet
50. and dry swallows. J Appl Physiol 1973;35:851–7.
51. Hollis JB, Castell DO. Effect of dry swallows and wet swallows of
52. different volumes on esophageal peristalsis. J Appl Physiol
53. ;38:1161–4.
54. Ertekin C, Aydogdu I. Electromyography of human cricopharyngeal
55. muscle of the upper esophageal sphincter. Muscle Nerve 2002;
56. :729–39.
57. Miller AJ. The neurobiology of swallowing and dysphagia. Dev
58. Disabil Res Rev 2008;14:77–86.
59. Ertekin C, K›yl›o¤lu N, Tarlac› S, Keskin A, Aydo¤du I. Effect of
60. mucosal anaesthesia on oropharyngeal swallowing. Neurogastroenterol
61. Motil 2000;12:567–72.
62. Ali GN, Laundl TM, Wallace KL, Shaw DW, deCarle DJ, Cook
63. IJ. Influence of mucosal receptors on deglutive regulation of pharyngeal
64. and upper esophageal sphincter function. Am J Physiol
65. ;267:G644–9.
66. Mansson I, Sandberg N. Effect of surface anesthesia on deglutition
67. in man. Laryngoscope 1974;84:427–37.
68. Mansson I, Sandberg N. Salivary stimulus and swallowing reflex in
69. man. Acta Otolaryngol 1975;79:445–50.
70. Jean A, Dallaporta M. Electrophysiologic characterization of the
71. swallowing pattern generator in the brainstem. GI Motility Online
72. ; DOI: http://dx.doi.org/10.1038/gimo9
73. Jean A, Car A, Roman C. Comparison of activity in pontine versus
74. medullary neurons during swallowing. Exp Brain Res 1975;22:211–
75. -
76. Jafari S, Prince RA, Kim DY, Paydarfar D. Sensory regulation of
77. swallowing and airway protection: a role for the internal superior
78. laryngeal nerve in humans. J Physiol 2003;550:287–304.
79. Lowell SY, Poletto CJ, Bethany RKC, Reynolds RC, Simonyan K,
80. Ludlow CL. Sensory stimulation activates both motor and sensory
81. components of the swallowing system. Neuroimage 2008;42:285–95.
82. Miller AJ. The neuroscientific principles of swallowing and dysphagia.
83. San Diego (CA): Singular Publication Group; 1999.
84. Jean A. Brainstem organisation of the swallowing network. Brain
85. Behav Evol 1984;25:109–16.
86. Jean A. Control of the central swallowing program by inputs from the
87. principal receptors. A review. J Auton Nerv Syst 1986;10:225–33.
88. Logemann JA. Evaluation and treatment of swallowing disorders.
89. nd ed. Austin (TX): Pro Ed; 1998.
90. Palmer JB, Rudin NJ, Lara G, Crompton AW. Coordination of
91. mastication and swallowing. Dysphagia 1992;7:187–200.
92. Pouderoux P, Logemann JA, Kahrilas PJ. Pharyngeal swallowing
93. elivcited by fluid infusion: role of volition and vallecular containment.
94. Am J Physiol 1996;270:G347–54.
95. Dua KS, Ren J, Bardon E, Xie P, Shaker R. Coordination of deglutive
96. glottal function and pharyngeal bolus transit during normal
97. eating. Gastroenterology 1997;112:73–83.
98. Hiiemae KM, Palmer JB. Food transport and bolus formation during
99. complete feeding sequences on foods of different initial consistencies.
100. Dysphagia 1999;14:31–42.
101. Chi-Fishman G, Sonies BC. Motor strategy in rapid sequential
102. swallowing: New insights. J Speech Lang Hear Res 2000;43:1481–
103. -
104. Daniels SK, Foundas AL. Swallowing physiology of sequential
105. straw drinking. Dysphagia 2001;16:176–82.
106. Daniels SK, Grey D, Hadskey LD, Legendre C, Priestly DH,
107. Rosenbek JC, Foundas AC. Mechanism of sequential swallowing
108. during straw drinking in healty young and older adults. J Speech
109. Lang Hear Res 2004;47:33–45.
110. Kessler JP, Jean A. Identification of medullary swallowing regions
111. in the rat. Exp Brain Res. 1985;57:256–63.
112. Ertekin C, Celik M, Seçil Y, Tarlaci S, Kiylio¤lu N, Aydo¤du I.
113. The electromyographic behaviour of the thyroarytenoid muscle
114. during swallowing. J Clin Gastroenterol 2000;30:274–80.
115. Ertekin C, Pehlivan M, Aydo¤du I, Ertafl M, Uluda¤ B, Celebi G,
116. Colako¤lu Z, Sa¤duyu A, Yüceyar N. An electrophysiological
117. investigation of deglutition in man. Muscle Nerve1995;18:1177–
118. -
119. Ludlow CL, Vanpelt F, Koda J. Characteristics of late responses to
120. superior laryngeal nerve stimulation in humans. Ann Otol Rhinol
121. Laryngol 1992;101:127–34.
122. Sasaki CT, Suzuki M. Laryngeal reflexes in cat, dog and man. Arch
123. Otolaryngol 1976;102:400–2.
124. Barkmeier JM, Bielamowicz S, Takeda N, Ludlow L. Modulation
125. of laryngeal responses to superior laryngeal nerve stimulation by
126. volutional swallowing in awake humans. J Neurophysiol
127. ;83:1264–72.
128. Esaki H, Toshiro U, Selh T, Shin T. Characteristics of laryngeal
129. receptors analysed by presynaptic recording from the cat medulla
130. oblongata. Auris Nasus Larynx 1997;24:73–93.
131. Celik M, Alkan Z, Ercan I, Ertaflo¤lu H, Alk›m C, Erdem L
132. Turgut S, Ertekin C. Cricopharyngeal muscle electromyography
133. in laryngopharyngeal reflux. Laryngoscope 2005;115:138–48.
134. Andreatta RD, Mann EA, Poletto CJ, Ludlow CL. Mucosal afferents
135. mediate laryngeal adductor responses in the cat. J Appl Physiol
136. ;93:1622–9.
137. Shaker R, Dodds WJ, Dantas RO, Hogan WJ, Arndorfer RC.
138. Coordination of deglutitive glottic closure with oropharyngeal
139. swallowing. Gastroenterology 1990;98:1478–84.
140. Martin BJW, Logemann JA, Shaker R, Dodds WJ. Coordination
141. between respiration and swallowing: respiratory phase relationship
142. and temporal integration. J Appl Physiol 1994;76:714–24.
143. Curtis DJ, Cruess DF, Dachman AH, Maso E. Timing in the normal
144. pharyngeal swallow: prospective selection and evaluation of 18
145. normal asymptomatic patients investigation. Invest Radiol 1984;
146. :523–9.
147. McConnell FM, Cerenko D, Jackson RT, Guffin Tn Jr. Timing of
148. major event of pharyngeal swallowing. Arch Otolaryngol Head
149. Neck Surg 1988;114:1413–8.
150. Kendall KA, McKenzie S, Leonard RJ, Gonçalves MI, Walker A.
151. Timing events in normal swallowing: a videofluoroscopic study.
152. Dysphagia 2000;15:74–83.
153. Kendall KA. Oropharyngeal swallowing variability. Laryngoscope
154. ;112:547–51.
155. Kendall KA, Leonard RJ, McKenzie SW. Sequence variability
156. during hypopharyngeal bolus transit. Dysphagia 2003;18:85–91.
157. Ohmae Y, LogemannJA, Kaiser P, Hansen DG, Kahrilas PJ.
158. Timing of glottic closure during normal swallow. Head Neck
159. ;17:394–402.
160. Celik Gokyigit M, Kuloglu Pazarci N, Ercan I, Seker S, Turgut S,
161. Ertekin C. Identification of distinct swallowing patterns for different
162. bolus volumes. Clin Neurophysiol 2009;120:1750–4.
163. Dozier TS, Brodsky MB, Michel Y, Walters Jr BC, Martin-Harris
164. B. Coordination of swallowing and respiration in normal sequential
165. cup swallows. Laryngoscope 2006;116:489–93.