MANAGING EPILEPSY BY MODULATING GLIA

Year 2016, Volume 10, Issue 1, 50 - 59, 01.05.2016

Medine Gülçebi İdrizoğlu Nihan Carcak Filiz Yılmaz Onat

Abstract

Antiepileptic drugs suppress epileptic seizures and provide a symptomatic control of seizures rather than anti-epileptogenic effects. Evidence about links between glial functions and neuronal signaling has been accumulating and has opened a perspective for the development of anti-epileptogenic approaches for the management of convulsive and non-convulsive forms of epilepsy. Astrocytic excitability and glial transmission have been shown to play critical roles in epileptogenesis and seizure generation. Although glial cells in convulsive types of epilepsy have been widely studied, little work has been done on the contribution of these cells in the non-convulsive epilepsy forms, particularly in absence epilepsy. This review underlies the participation of reactive astrocytes, glia modulating approaches and the roles of inflammatory cytokines in the modulation of convulsive and non-convulsive forms of epilepsy. The understanding of links between astrocyte functions and neuronal signaling in epileptogenesis will be one of the top epilepsy research advances in the future.

Keywords

antiepileptic, astrocyte, epileptogenic, microglia, seizure

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