Research Article
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Year 2015, Volume: 9 Issue: 3, 168 - 176, 01.02.2016

Abstract

References

  • Nicholas JW, Breman JG. Malaria and babeiosis; diseases caused by red blood cell parasites. In: Kasper DL, Braunwald E, Hauser S, Longo D, Jameson JL, Fauci AS, editors. Harrison’s principles of internal medicine. 16th ed. New York: McGraw Hill; 2005. p. 1218.
  • World Health Organization. Malaria chemotherapy. WHO technical report series. Geneva: WHO; 1998. 1998.
  • Palmer J. WHO gives indoor use of DDT a clean bill of health for controlling malaria. Indian J Med Sci 2006;60:439–41.
  • Hall N, Karras M, Raine JD, Carlton JM, Kooij TW, Berriman M, Florens L, Janssen CS, Pain A, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell SL, Rajandream MA, Carucci DJ, Yates JR 3rd, KafatosFC, Janse CJ, Barrell B, Turner CM, Waters AP, Sinden RE. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science 2005;307:82–6.
  • Kooij TW, Janse CJ, Waters AP. Plasmodium post-genomics: better the bug you know? Nat Rev Microbiol 2006;4:344–57.
  • Good MF. The hope but challenge for developing a vaccine that might control malaria. Eur J Immunol 2009;39:939–43.
  • World Health Organization. Guidelines for the treatment of malaria. 3rd ed. Geneva: WHO; 1998. 316 p.
  • Dondorp AM, Desakorn V, Pongtavornpinyo W, Sahassananda D,
  • Silamut K, Chotivanich K, Newton PN, Pitisuttithum P, Smithyman AM, White NJ, Day NP. Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med 2005;2:e204.
  • Bartoloni A, Zammarchi L. Clinical aspects of uncomplicated and severe malaria. Mediterr J Hematol Infect Dis 2012;4:e2012026.
  • Nadjm B, Behrens RH. Malaria: an update for physicians. Infect Dis Clin North Am 2012;26:243–59.
  • World Health Organization. Malaria chemoprophylaxis: problems
  • associated with the chemoprophylaxis of travellers to endemic
  • areas. Wkly Epidemiol Rec 1986;61:109–16.
  • Cook GC. Plasmodium falciparum infection: problems in prophylaxis
  • and treatment in 1986. Q J Med 1986;61:1091–115.
  • Pillay VV. Modern medical toxicology. 4th ed. New Delhi: Jaypee Publishers; 2013. 460 p.
  • Rouveix B, Bernard J, Michon C. Mefloquine and anacute brain syndrome. Ann Intern Med 1989;110:577–8.
  • Rupani AB, Amarapurkar AD. Hepatic changes in fatal malaria: an emerging problem. Ann Trop Med Parasitol 2009;103:119–27.
  • Whitten R, Milner DA Jr, Yeh MM, Kamiza S, Molyneux ME, Taylor TE. Liver pathology in Malawian children with fatal encephalopathy. Hum Pathol 2011;42:1230–9.
  • ChawlaLS, Sidhu G, Sabharwal BD, Bhatia K, Lsood A. Jaundice in Plasmodium falciparum malaria. J Assoc Physicians India 1989; 37:390–2.
  • Srivastava HC, Sharma SK, Bhatt RM, Sharma VP. Studies on Plasmodium vivax relapse pattern in Kheda district, Gujarat. Indian J Malariol 1996;33:173–9.
  • Viriyavejakul P, Khachonsaksumet V, Punsawad C. Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression. Malar J 2014;13:106.
  • Rungruang T, Kaewkongkwan Y, Sukakul T, Kettawan A, Chompoopong S, Boonmars T. The effect of vitamin C on morphology and histology of liver and spleen of Plasmodium-infected mice. International Food Research Journal 2013;20:1639–43.
  • Ross IA. Medicinal plants of the world. Vol 1. Clifton (NJ): Humana Press; 1999. p. 199–202.
  • Scartezzini P, Speroni E. Review on some plants of Indian traditional medicinewith antioxidant activity. J Ethnopharmacol 2000; 71:23–43.
  • Oyewo OO, Onyije FM, Ashamu EA, Akintunde OW, Ayeni OJ. Evaluation of aqueous stem bark extract of Mangifera indica on the liver of Wistar rats. Asian Journal of Pharmaceutical and Biological Research 2012; 2:231–3.
  • Basir R, Rahiman SF, Hasballah K, Chong W, Talib H, Yam M, Jabbarzare M, TieT, Othman F, Moklas M, Abdullah W, Ahmad
  • Z. Plasmodium berghei ANKA Infection in ICR mice as a model of cerebral malaria. Iran J Parasitol 2012;7:62–74.
  • Yeshanew S, Mekonnen Y. The effect of Otostegia integrefolia leaf extracts on the packed cell volume, body weight and survival time of Plasmodium berghei infected mice. International Journal of Tropical Medicine2013;8:129–34.
  • Perlmann P, Troye-Blomberg M, editors. Malaria immunology. 2nd ed. Basel: Karger; 2002.
  • Nwinuka NM, Monanu MO, Nwiloh BI. Effects of aqueous extract of Mangifera indica L. (Mango) stem bark on haemoatological parameters
  • of normal albino rats. Pakistan Journal of Nutrition 2008; 7:663–8.
  • Sellamuthu PS, Muniappan BP, Perumal SM, Kandasamy M. Antihyperglycemic effect of mangiferin in streptozotocin induced diabetic rats. Journal of Health Sciences 2009;55:206–14.
  • Ramalhete C, da Cruz FP, Mulhovo S, Sousa IJ, Fernandes MX, Prudencio M, Ferreira MJU. Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite. Bioorg Med Chem 2014;22:3887–90.
  • Georgewill UO, Ebong OO. A comparative study on the efficacy of some artemisinin combination therapies on Plasmodium berghei in Swiss albino mice. Pharmacol Pharm 2012;3:109–12.
  • Bhalla A, Suri V, Singh V. Malarial hepatopathy. J Postgrad Med 2006;52:315–20.
  • Hamman WO, Musa SA, Muzaffar F, Sani SO, Umana UE, Timbual JA, Nok AJ, Ojo SA. Acute exposure to artesunate and its effect on the hematological indices, hepatotoxicity and histology of the liver of adult wistar rats. Asian Journal of Medical Sciences 2011;3:176–9.
  • Rasool M, Sabina EP, Mahinda PS, Gnanselvi BC. Mangiferin, a natural polyphenol protects the hepatic damage in mice caused by CCl4 intoxication. Comp Clin Path 2012;21:865– 72.
  • Rojkind M, Giambrone MA, Biempica L. Collagen types in normal and cirrhoticliver. Gastroenterology 1979;76:710–9.
  • Lee ES, Lee HE, Shin JY, Yoon S, Moon JO. The flavonoids quercetin inhibits dimethylnitrosamine-induced liver damage in rats. J Pharm Pharmacol 2003;55:1169–74.
  • Yuan LP, Chen FH, Ling L, Bo H, Chen ZW, Li F, Zhong MM, Xia LJ. Protective effects of total flavonoids of Biden bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats. J Pharm Pharmacol 2008;60:1393–402.
  • Miura S, Suematsu M, Tanaka S, Nagata H, Houzawa S, Suzuki M, Kurose I, Serizawa H, Tsuchiya M. Microcirculatory disturbance in indomethacin-inducedintestinal ulcer. Am J Physiol 1991; 261:G213–9.
  • Dharmeshkumar NP, Pradeep P, Surti MM, Agarwal SB. Clinical manifestation of complicated malaria an overview. Journal of Indian Academy of Clinical Medicine 2003;4:323–31.
  • Soniran OT, Idowu OA, Ajayi OL, Olubi IC. Comparative study on the effects of chloroquine and artesunate on histopathological damages caused by Plasmodium berghei in four vital organs of infected albino mice. Malar Res Treat 2012;2012:960758.

HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.)

Year 2015, Volume: 9 Issue: 3, 168 - 176, 01.02.2016

Abstract

Objectives: This study was carried out to assess the histomorphological findings of the liver of Plasmodium-infected albino mice following administration of aqueous leaf extract of Mangifera indica.
Methods: Forty-two male albino mice, weighing 20–25 g, were used for this research. The mice were randomly assigned into six groups A, B, C, D, E and F (n=7, each). Groups B, C, D, E and F were infected with P. berghei, while group A was administered equivalent volume of normal saline. Mice in groups C, D and E were orally administered Mangifera indica extract (50 mg/kg, 100 mg/kg and 150 mg/kg body weight, respectively) dissolved in 0.2 ml of distilled water for 5 days, and those in group F were orally administered with artesunate for 5 days (3 mg/kg and 1.5 mg/kg body weight on the first day and on subsequent 4 days, respectively) while groups A and B were administered equivalent volume of distilled water, all administrations starting 72 hours post-infection. The animals were left for another 14 days after treatment.
Results: The result showed that the extract treated groups presented dose dependent ameliorative changes in the organization of histoarchitecture such as reduction of collagen fibers, reticular fibers and hemozoins. There was a significant decrease (p<0.0001) in the percentage parasitemia in groups C, D and E when compared with group B. There was also a significant (p<0.03) reduction in Kupffer cell density in groups C, D and E when compared with group B.
Conclusion: This study showed that Mangifera indica has an ameliorative effect against injury-related changes in liver histomorphology.

References

  • Nicholas JW, Breman JG. Malaria and babeiosis; diseases caused by red blood cell parasites. In: Kasper DL, Braunwald E, Hauser S, Longo D, Jameson JL, Fauci AS, editors. Harrison’s principles of internal medicine. 16th ed. New York: McGraw Hill; 2005. p. 1218.
  • World Health Organization. Malaria chemotherapy. WHO technical report series. Geneva: WHO; 1998. 1998.
  • Palmer J. WHO gives indoor use of DDT a clean bill of health for controlling malaria. Indian J Med Sci 2006;60:439–41.
  • Hall N, Karras M, Raine JD, Carlton JM, Kooij TW, Berriman M, Florens L, Janssen CS, Pain A, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell SL, Rajandream MA, Carucci DJ, Yates JR 3rd, KafatosFC, Janse CJ, Barrell B, Turner CM, Waters AP, Sinden RE. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science 2005;307:82–6.
  • Kooij TW, Janse CJ, Waters AP. Plasmodium post-genomics: better the bug you know? Nat Rev Microbiol 2006;4:344–57.
  • Good MF. The hope but challenge for developing a vaccine that might control malaria. Eur J Immunol 2009;39:939–43.
  • World Health Organization. Guidelines for the treatment of malaria. 3rd ed. Geneva: WHO; 1998. 316 p.
  • Dondorp AM, Desakorn V, Pongtavornpinyo W, Sahassananda D,
  • Silamut K, Chotivanich K, Newton PN, Pitisuttithum P, Smithyman AM, White NJ, Day NP. Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med 2005;2:e204.
  • Bartoloni A, Zammarchi L. Clinical aspects of uncomplicated and severe malaria. Mediterr J Hematol Infect Dis 2012;4:e2012026.
  • Nadjm B, Behrens RH. Malaria: an update for physicians. Infect Dis Clin North Am 2012;26:243–59.
  • World Health Organization. Malaria chemoprophylaxis: problems
  • associated with the chemoprophylaxis of travellers to endemic
  • areas. Wkly Epidemiol Rec 1986;61:109–16.
  • Cook GC. Plasmodium falciparum infection: problems in prophylaxis
  • and treatment in 1986. Q J Med 1986;61:1091–115.
  • Pillay VV. Modern medical toxicology. 4th ed. New Delhi: Jaypee Publishers; 2013. 460 p.
  • Rouveix B, Bernard J, Michon C. Mefloquine and anacute brain syndrome. Ann Intern Med 1989;110:577–8.
  • Rupani AB, Amarapurkar AD. Hepatic changes in fatal malaria: an emerging problem. Ann Trop Med Parasitol 2009;103:119–27.
  • Whitten R, Milner DA Jr, Yeh MM, Kamiza S, Molyneux ME, Taylor TE. Liver pathology in Malawian children with fatal encephalopathy. Hum Pathol 2011;42:1230–9.
  • ChawlaLS, Sidhu G, Sabharwal BD, Bhatia K, Lsood A. Jaundice in Plasmodium falciparum malaria. J Assoc Physicians India 1989; 37:390–2.
  • Srivastava HC, Sharma SK, Bhatt RM, Sharma VP. Studies on Plasmodium vivax relapse pattern in Kheda district, Gujarat. Indian J Malariol 1996;33:173–9.
  • Viriyavejakul P, Khachonsaksumet V, Punsawad C. Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression. Malar J 2014;13:106.
  • Rungruang T, Kaewkongkwan Y, Sukakul T, Kettawan A, Chompoopong S, Boonmars T. The effect of vitamin C on morphology and histology of liver and spleen of Plasmodium-infected mice. International Food Research Journal 2013;20:1639–43.
  • Ross IA. Medicinal plants of the world. Vol 1. Clifton (NJ): Humana Press; 1999. p. 199–202.
  • Scartezzini P, Speroni E. Review on some plants of Indian traditional medicinewith antioxidant activity. J Ethnopharmacol 2000; 71:23–43.
  • Oyewo OO, Onyije FM, Ashamu EA, Akintunde OW, Ayeni OJ. Evaluation of aqueous stem bark extract of Mangifera indica on the liver of Wistar rats. Asian Journal of Pharmaceutical and Biological Research 2012; 2:231–3.
  • Basir R, Rahiman SF, Hasballah K, Chong W, Talib H, Yam M, Jabbarzare M, TieT, Othman F, Moklas M, Abdullah W, Ahmad
  • Z. Plasmodium berghei ANKA Infection in ICR mice as a model of cerebral malaria. Iran J Parasitol 2012;7:62–74.
  • Yeshanew S, Mekonnen Y. The effect of Otostegia integrefolia leaf extracts on the packed cell volume, body weight and survival time of Plasmodium berghei infected mice. International Journal of Tropical Medicine2013;8:129–34.
  • Perlmann P, Troye-Blomberg M, editors. Malaria immunology. 2nd ed. Basel: Karger; 2002.
  • Nwinuka NM, Monanu MO, Nwiloh BI. Effects of aqueous extract of Mangifera indica L. (Mango) stem bark on haemoatological parameters
  • of normal albino rats. Pakistan Journal of Nutrition 2008; 7:663–8.
  • Sellamuthu PS, Muniappan BP, Perumal SM, Kandasamy M. Antihyperglycemic effect of mangiferin in streptozotocin induced diabetic rats. Journal of Health Sciences 2009;55:206–14.
  • Ramalhete C, da Cruz FP, Mulhovo S, Sousa IJ, Fernandes MX, Prudencio M, Ferreira MJU. Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite. Bioorg Med Chem 2014;22:3887–90.
  • Georgewill UO, Ebong OO. A comparative study on the efficacy of some artemisinin combination therapies on Plasmodium berghei in Swiss albino mice. Pharmacol Pharm 2012;3:109–12.
  • Bhalla A, Suri V, Singh V. Malarial hepatopathy. J Postgrad Med 2006;52:315–20.
  • Hamman WO, Musa SA, Muzaffar F, Sani SO, Umana UE, Timbual JA, Nok AJ, Ojo SA. Acute exposure to artesunate and its effect on the hematological indices, hepatotoxicity and histology of the liver of adult wistar rats. Asian Journal of Medical Sciences 2011;3:176–9.
  • Rasool M, Sabina EP, Mahinda PS, Gnanselvi BC. Mangiferin, a natural polyphenol protects the hepatic damage in mice caused by CCl4 intoxication. Comp Clin Path 2012;21:865– 72.
  • Rojkind M, Giambrone MA, Biempica L. Collagen types in normal and cirrhoticliver. Gastroenterology 1979;76:710–9.
  • Lee ES, Lee HE, Shin JY, Yoon S, Moon JO. The flavonoids quercetin inhibits dimethylnitrosamine-induced liver damage in rats. J Pharm Pharmacol 2003;55:1169–74.
  • Yuan LP, Chen FH, Ling L, Bo H, Chen ZW, Li F, Zhong MM, Xia LJ. Protective effects of total flavonoids of Biden bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats. J Pharm Pharmacol 2008;60:1393–402.
  • Miura S, Suematsu M, Tanaka S, Nagata H, Houzawa S, Suzuki M, Kurose I, Serizawa H, Tsuchiya M. Microcirculatory disturbance in indomethacin-inducedintestinal ulcer. Am J Physiol 1991; 261:G213–9.
  • Dharmeshkumar NP, Pradeep P, Surti MM, Agarwal SB. Clinical manifestation of complicated malaria an overview. Journal of Indian Academy of Clinical Medicine 2003;4:323–31.
  • Soniran OT, Idowu OA, Ajayi OL, Olubi IC. Comparative study on the effects of chloroquine and artesunate on histopathological damages caused by Plasmodium berghei in four vital organs of infected albino mice. Malar Res Treat 2012;2012:960758.
There are 45 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Ahmed A. Olayode This is me

David A. Ofusori This is me

Titus A. B. Ogunniyi This is me

Olusola S. Saka This is me

Publication Date February 1, 2016
Published in Issue Year 2015 Volume: 9 Issue: 3

Cite

APA Olayode, A. A., Ofusori, D. A., Ogunniyi, T. A. B., Saka, O. S. (2016). HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.). Anatomy, 9(3), 168-176.
AMA Olayode AA, Ofusori DA, Ogunniyi TAB, Saka OS. HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.). Anatomy. February 2016;9(3):168-176.
Chicago Olayode, Ahmed A., David A. Ofusori, Titus A. B. Ogunniyi, and Olusola S. Saka. “HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.)”. Anatomy 9, no. 3 (February 2016): 168-76.
EndNote Olayode AA, Ofusori DA, Ogunniyi TAB, Saka OS (February 1, 2016) HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.). Anatomy 9 3 168–176.
IEEE A. A. Olayode, D. A. Ofusori, T. A. B. Ogunniyi, and O. S. Saka, “HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.)”, Anatomy, vol. 9, no. 3, pp. 168–176, 2016.
ISNAD Olayode, Ahmed A. et al. “HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.)”. Anatomy 9/3 (February 2016), 168-176.
JAMA Olayode AA, Ofusori DA, Ogunniyi TAB, Saka OS. HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.). Anatomy. 2016;9:168–176.
MLA Olayode, Ahmed A. et al. “HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.)”. Anatomy, vol. 9, no. 3, 2016, pp. 168-76.
Vancouver Olayode AA, Ofusori DA, Ogunniyi TAB, Saka OS. HISTOMORPHOLOGICAL STUDIES OF THE LIVER OF PLASMODIUM-INFECTED ALBINO MICE AFTER ADMINISTRATION OF AQUEOUS LEAF EXTRACT OF MANGIFERA INDICA (LINN.). Anatomy. 2016;9(3):168-76.

Anatomy is the official journal of Turkish Society of Anatomy and Clinical Anatomy (TSACA).