Development of a Sensitive Electrochemical Sensor for the Simultaneous Quantification of Acetaminophen Traces onto Carbon Paste Electrode Modified with Black Carbon and La0.6Sr0.4Co0.8Fe0.2O3 Nano-Sized Particles

Year 2025, Volume: 4 Issue: 1, 27 - 47

Mosbah Ferkhi , Mouna Mekersi Ebru Kuyumcu Savan

https://doi.org/10.71133/anatphar.1594005

Abstract

Recently, the development of an advanced electrochemical sensor has received tremendous attention in the field of drug monitoring. The La0.6Sr0.4Co0.8Fe0.2O3 (LSCF) nano-sized oxides were synthesized by a simple sol-gel citrate method, modified with black carbon (BC) and prepared as a carbon paste electrode (CPE) for the simultaneous determination of paracetamol (PCM) traces presence in PBS electrolyte through cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) as sensing techniques. X-ray diffraction (XRD), scanning electron microscopy (SEM), and Ferrocyanide test were characterization techniques. The calculated crystallite size d, was found to be 208.317 nm by XRD and 65.05 nm by SEM analysis. In conclusion, the modified prepared sensor LSCF/BC/CPE demonstrates a very satisfactory response, sensitivity, and selectivity towards PCM molecules compared with literature with a very low detection limit of 36 nM, high sensitivity of 75 µA.µM−1.cm−2, with a wide linear range from 0.1 µM to 180 µM by DPV technique. The modified LSCF/BC/CPE sensor demonstrated excellent results in the real pharmaceutical sample with a very good recovery of 94.56 % and a satisfactory relative standard deviation of 3.26 %.

Keywords

Sensor, Nanoparticles, Black carbon, Paracetamol, Cyclic voltammetry, Differential pulse voltammetry.

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