Evaluation of Some Common Small Mammal Species in Western Anatolia for Orthohantavirus Carriage

Abstract

Orthohantaviruses, members of the Hantaviridae family, are rodent-borne RNA viruses. They transmitted by aerosolization of viral particles in the excretions and secretions of infected rodents and rarely by direct contact with infected rodents. They are an important public health concerns that cause hemorrhagic fever with renal syndrome and epidemic nephropathy cases in Eurasia and hantavirus cardiopulmonary syndrome cases in the Americas. They have also been reported to cause infections in Turkey and their presence in rodents have been indicated. We aimed to determine the circulating orthohantaviruses and possible host species in some provinces of Western Anatolia where hemorrhagic fever with renal syndrome cases have been reported. Serum and lung tissue samples of 49 rodents collected from seven localities during a one-week field study were used. No positivity for Orthohantavirus infection was detected in the samples screened by both molecular and serologic methods. This situation may be related to the temporal, regional and climatic characteristics of the sampling areas. The evaluation of rodents in Western Anatolia in terms of Orthohantavirus carriage is important due to the cases reported from the region. Since the sample size of this study was limited, a comprehensive study which includes possible host rodent species and samples collected from different periods is needed.

Keywords

• Orthohantavirus
• Microtus
• Apodemus
• Crocidura
• Anatolia
• Turkey

BATI ANADOLU’DAKİ BAZI YAYGIN KÜÇÜK MEMELİ TÜRLERİNİN ORTOHANTAVİRÜS TAŞIYICILIĞI AÇISINDAN DEĞERLENDİRİLMESİ

Abstract

Hantaviridae ailesinin üyesi olan ortohantavirüsler, kemirici kaynaklı RNA virüsleridir. Enfekte kemiricilerin çıkartı ve sekresyonlarındaki viral partiküllerin aerosolizasyonu ve nadiren de enfekte kemiricilerle direkt temas yolu ile bulaşan ortohantavirüsler, Avrasya'da renal sendromlu kanamalı ateş ve epidemik nefropati olgularına, Amerika kıtasında ise hantavirüs kardiyopulmoner sendrom olgularına neden olabilen önemli halk sağlığı sorunlarıdır. Türkiye’de de enfeksiyonlara neden oldukları bildirilmiş ve küçük memelilerdeki varlıkları gösterilmiştir. Bu çalışma ile renal sendromlu kanamalı ateş olgularının bildirildiği bazı Batı Anadolu illerinde dolaşımda olan ortohantavirüslerin ve olası konak türlerinin belirlenmesi amaçlanmıştır. Çalışma kapsamında yedi farklı lokaliteden yakalanan 49 adet küçük memeliye ait serum ve akciğer dokusu örnekleri kullanılmıştır. Hem moleküler hem de serolojik yöntemler ile taranan örneklerde, Ortohantavirüs enfeksiyonuna yönelik bir pozitiflik saptanmamıştır. Bu durum, örneklem alanlarının zamansal, bölgesel ve iklimsel özelliklerinden kaynaklanmış olabilir. Batı Anadolu’daki küçük memelilerin Ortohantavirüs taşıyıcılıklarının değerlendirilmesi, bölgeden bildirilmiş vakalar olması nedeniyle önem taşımaktadır. Bu çalışmanın örneklemi sınırlı

Keywords

• Orthohantavirus
• Microtus
• Apodemus
• Crocidura
• Anadolu
• Türkiye

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