Kafeik Asit Fenetil Ester KAFE ve Miyokardiyal İskemi Reperfüzyon Mİ/R Hasarı

Year 2012, Volume: 1 Issue: 1, 10 - 15, 01.04.2012

Hakan Parlakpınar Mehmet Hamdi Örüm Ahmet Acet

Abstract

İskemi, doku hasarı ile sonuçlanan, dokuya yetersiz oksijen ve besin desteğine yol açan kan akımı durması veya azalmasını ifade eder. Miyokard dokusunun yaşamının devam edebilmesi için iskemik alanın erken reperfüzyonu önemlidir. Ancak reperfüzyonun kendisi de, reperfüzyon hasarı olarak adlandırılan miyokard hücrelerinin ölümü ile sonuçlanır. Miyokardiyal iskemi-reperfüzyon Mİ/R hasarının özellikle reperfüzyon dönemindeki artmış serbest radikal üretimi ve hücre içi aşırı kalsiyum yüklenmesi ile ilişkili olduğuna inanılmaktadır. Araştırmacılar, Mİ/R hasarını önlemek için kullanılabilecek ajanlar üzerinde pek çok çalışmalar yapmaktadır. Bal arısı kovanlarından elde edilen propolisin aktif bir bileşeni olan kafeik asit fenetil ester KAFE ’ nin antikarsinojenik, immünomodülatör, antiinflamatuvar ve antioksidan özelliklerinin olduğu bilinmektedir. KAFE, serbest radikalleri süpüren ve antioksidan enzimleri aktive eden bir ajandır. Bu bulgular KAFE’ nin iskemik kalp hastalıklarının önlenmesi ve tedavisinde, özellikle hayatı tehdit eden reperfüzyon aritmilerinde ve ileriki yaşam kalitesini etkileyebilen infarkt alanının önlenmesinde klinik olarak test edilebileceğini düşündürmektedir. Bu derlemede Mİ/R hasarının mekanizmaları ve KAFE’ nin Mİ/R ile ilgili hasar üzerindeki etkilerinin gözden geçirilmesi amaçlandı

Keywords

Kafeik asit fenetil ester, Miyokardiyal iskemi/reperfüzyon, Propolis

Caffeic Acid Phenethyl Ester CAPE and Myocardial Ischemia Reperfusion MI/R Injury

Abstract

Ischemia refers to lack of or decreased blood flow, which leads insufficient oxygen and nutrient supply to the tissue, which in turn results in tissue damage. Early reperfusion of the ischemic area is important in viability of the myocardial tissue. However, reperfusion also often results in injury to the myocardial cells, which has been termed reperfusion injury. It is believed that MI/R injury is related to increased free radical formation and calcium overloading especially during the reperfusion period. Researchers are working on the agents that can be used to prevent MI/R injury. Caffeic acid phenethyl ester CAPE , an active component of propolis from honeybee hives, is known to have anticarcinogenic, immunomodulatory, antiinflammatory, and antioxidant properties. It has been demonstrated that CAPE is an agent which is a free radical scavenger and activates antioxidant enzymes. These findings thought that CAPE would be valuable to test in clinical trials for prevention and of possible MI/R-induced injury, especially life threatening reperfusion-induced arrhythmias and infarct size effecting life quality. In this review we have summarized the mechanisms of MI/R injury and the effects of CAPE on myocardial damage that related to MI/R injury

Keywords

Caffeic acid phenethyl ester, Myocardial ischemia/reperfusion, Propolis

References

• McGovern PG, Pankow JS, Shahar E et al. Recent trials in acute coronary disease: mortality, morbidity, medical care and risk factors: the Minnesota Heart Survey Investigators. N Engl J Med 1996; 334: 884-90.
• Lefer DJ, Granger DN. Oxidative stres and cardiac disease. Am J Med 2000; 109: 315-23.
• Aksulu HE, Ercan ZS, Türker RK. Further studies on the antiarrhythmic Pharmacodyn Ther 1985; 277: 223-34. iloprost. Arch Int
• Izumi T, Saito Y, Kishimoto I. Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-κB ischemia/reperfusion injury. J Clin Invest 2001; 108: 203–13. alleviates myocardial
• Hilmi Ş. Oksidanlar ve antioksidanlar. Türk Hastane Tıp Dergisi 1994; 48 (1-2): 44-9.
• Ozyurt H, Irmak MK, Akyol O, Sogut S. Caffeic acid phenethyl ester changes the indices of oxidative stress in serum of rats with renal ischaemia-reperfusion injury. Cell Biochem Funct 2001; 19(4): 259-63.
• Ozer MK, Parlakpinar H, Acet A. Reduction of ischemia-reperfusion induced myocardial infarct size in rats by caffeic acid phenethyl ester (CAPE). Clin Biochem 2004; 37(8): 702-5.
• Brown R. Honey royden brown’s bee hive product bible. 2000; 123: 33.
• National Honey Board. Carbohydrates and the Sweetness of Honey. 2010.
• USDA Nutrient Data Laboratory "Honey". 2007. http://www.nal.usda.gov/fnic/foodcomp/search/
• Gheldof N, Wang X, Engeseth N. Identification and quantification of antioxidant components of honeys from various floral sources. J Agric Food Chem 2002; 50 (21): 5870-7.
• Beretta G, Orioli M, Facino RM. Antioxidant and radical scavenging activity of honey in endothelial cell cultures. Planta Med 2007; 73(11): 1182-89.
• Ivanov DF, Tikonov AI, Krivenchuk PE, Liurskaia FV. Propolis and its clinical usage. Oftolmol Zh 1973; 28(2): 104-7.
• Krol W, Scheller S, Shani J, Pietsz G, Czubaz. Synergistic effect of ethanolic extract of propolis and antibiotics on the growth of Staphylococcus aureus. Arzneimittelforschung 1993; 43(5): 607-9.
• Bankova V, Dyulgerov A, Popov S, et al. Propolis produced in Bulgaria and Mongolia: phenolic compounds and plant origin. Apidologie 1992; 23: 79- 85.
• Persano Oddo L, Piro R. Main European unifloral honeys: Descriptive sheets. Apidologie 2004; 35: 38– 81.
• Conti ME. Lazio region (Central Italy) honeys: a survey of mineral content and typical quality parameters. Food Control 2000; 11: 459-63.
• Iskander FY. Trace and minor elements in four commercial honey brands. J Radioanalyt Nuclear Chem 1995; 201: 401–8.
• Rodriguez-Otero JL, Paseiro P, Simal J, Cepeda A. Mineral content of the honeys produced in Galicia (North-west Spain). Food Chem 1994; 49: 169-71.
• Deutsche Gesellschaft fu¨r Erna¨hrung. “Referenzwerte fu¨r die Na¨hrstoffzufuhr”. Umschau/Braus. Frankfurt am Main. 2000.
• Al-Mamary M, Al-Meeri A, Al-Habori M. Antioxidant activities and total phenolics of different types of honey. Nutr Res 2002; 22: 1041–47.
• Yilmaz H, Yavuz O. Content of some trace metals in honey from South-Eastern Anatolia. Food Chem 1999; 65: 475-6.
• Koltuksuz U, Irmak MK, Karaman A, et al. Testicular nitric torsion/detorsion in rats pretreated with caffeic acid phenethyl ester. Urol Res 2000; 28: 360-3. testicular
• Irmak MK, Koltuksuz U, Kutlu NO, et al. The effects of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with α-tocopherol in rat kidneys. Urol Res 2001; 29: 190-3.
• Hepşen IF, Tilgen F, Er H. Propolis: Tıbbi özellikleri ve oftalmolojik kullanımı. Turgut Özal Tıp Merkezi Dergisi 1996; 3: 386-91.
• Grunberger D, Banerjee R, Eisinger K, Oltz EM, Efras L, Coldwell M. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 1988; 44: 230-2.
• Sud'ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, Varfolomeev SD. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 1993; 329: 21-4.
• Michaluart P, Masferrer JL, Carothers AM, et al. Cancer Res 1999; 59, 2347-52.
• Kimura Y, Okuda H, Okuda T, Hatano T, Agata I, Arichi S. Studies on the activities of tannins and related compounds from medicinal plants and drugs. VII. Effects of extracts of leaves of Artemisia species, and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil. Chem Pharm Bull 1985; 33: 2028-34.
• Lee SK, Song L, Mata-Greenwood E, Kelloff GJ, Steele VE, Pezzuto JM. Modulation of in vitro biomarkers chemopreventive agents. Anticancer Res 1999; 19: 35- 44.
• Lang JD Jr, Figueroa M, Chumley P et al. Albumin and hydroxyethyl starch modulate oxidative inflammatory injury to vascular endothelium. Anesthesiology 2004; 100: 51-8.
• Turkoz Y, Er H, Borazan M et al. Use of caffeic acid phenethyl ester and cortisone may prevent proliferative vitreoretinopathy. Mediators of Inflammation, 2004; 13(2): 127-30.
• Parlakpinar H, Tasdemir S, Polat A, et al. Protective role of caffeic acid phenethyl ester (CAPE) on gentamicin-induced acute renal toxicity in rats. Toxicology 2005; 207 169-77.
• Zimmerman BJ, Granger DN. Reperfusion injury. Surg Clin North Am 1992; 72: 65-83.
• Xu KY, Zweier JL, Becker LC. Hydroxyl radical inhibits sarcoplasmic reticulum Ca21 ATPase function by direct attack on the ATP binding site. Circ Res 1997; 80: 76-81.
• Bolli R. Oxygen-derived free radicals and myocardial reperfusion injury: an overview. Cardiovasc Drugs Ther 1991; 5: 249-68.
• Wilhelm J. Metabolic aspects of membrane lipid peroxidation. Acta Univ Carol Med Monogr 1990; 137: 1-53.
• Hopkins PN, Williams RR. A survey of 246 suggested coronary risk factors. Atherosclerosis 1981; 40: 1-52.
• Entman ML, Smith CW. Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease. Cardiovasc Res 1994; 28: 1301-11.
• Kukielka GL, Hawkins HK, Michael L, et al. Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium. J Clin Invest 1993; 92: 1504-16.
• Reiter RJ, Tan DX. Melatonin: A novel protective agent against oxidative injury of the ischemic- reperfused heart. Cardiovascular Research 2003; 58: 10-9.
• Gross GJ, Kersten JR, Warltier DC. Mechanisms of postischemic contractile dysfunction. Ann Thorac Surg 1999; 68: 1898-904.
• Ozer MK, Parlakpinar H, Cigremis Y, Ucar M, Vardi N, Acet A. Ischemia reperfusion leads to depletion of glutathione malondialdehyde production in the rat heart from overproduction of oxidants: can caffeic acid phenethyl ester (CAPE) protect the heart? Mol Cel Biochem 2005; 273: 169-75.
• Parlakpinar H, Sahna E, Acet A, Mizrak B, Polat A. Protective effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia–reperfusion-induced apoptotic cell death. Toxicology 2005; 209: 1-14.
• Ozen S, Akyol O, Iraz M, et al. Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats. J Appl Toxicol 2004; 24: 27-35.
• Krol W, Scheller S, Czuba Z et al. Inhibition of neutrophils’ chemiluminescence by ethanol extract of propolis (EEP) and its phenolic Ethnopharmacol 1996; 55: 19-25. components.
• Jin WP, Quan XQ, Meng FP, Cui XD, Piao HJ. Relationship among hepatocyte apoptosis, P450 2E1 and oxidative stress in alcoholic liver disease of rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2007; 19(7): 419- 21.
• Ozer MK, Parlakpinar H, Acet A. Reduction of ischemia-reperfusion induced myocardial infarct size in rats by caffeic acid phenethyl ester (CAPE). Clin Biochem 2004; 37(8): 702-5.