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Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu

Year 2017, Volume: 6 Issue: 1, 37 - 39, 01.04.2017

Abstract

Langerhans hücreli histiositosisin LHH bir alt grubu olan, eosinofilik granülom çoğunlukla kemikleri etkileyen ve seyrek görülen bir hastalıktır. Özellikle çocuklarda görülen bir hastalık olup, erişkinlerde nadirdir. Bu yüzden erişkinlerdeki eosinofilik granülomlardaki karakteristik klinik tablo ve radyolojik görünümler için yapılmış yeterli klinik çalışma yoktur. Kliniğimize, baş ağrısı baş dönmesi ve dengesizlik şikâyetleriyle başvuran,50 yaşındaki bir hastada verteks bölgesinde 2x5 cm ebatlarında cilt altı yerleşimli sert bir kitle tespit edildi. Radyolojik görüntülerde, sol parietal kemiğin anteriorunda, verteks düzeyinde kemiği destrükte eden, subkutan ve intrakranial uzanım gösteren bir kitle tespit edildi. Kitle heterojen olarak kontrastlanmaktaydı. Durada kalınlaşma ve patolojik opaklanma mevcuttu. Parankimal tutulum yoktu. Kalvariyal metastaz ön tanısıyla yatırılarak ameliyat edilen hastanın, patoloji sonucu eosinofilik granülom olarak geldi. Sonuç olarak, kalvarial kemiği tutan lezyonlarda ön tanıda düşünülmesi gereken hastalıklar arasına, eosinifilik granülom da eklenmelidir

References

  • 1. Alexiou GA, Mpairamidis E, Sfakianos G. et al. Cranial unifocal Langerhans cell histiocytosis in children. J Pediatr Surg 2009; 44(3): 571-4.
  • 2. Broadvent V, Egeler RM, Nesbit ME Jr. Langerhans cell histiocytosis: clinical and epidemiological aspects. Br J Cancer suppl 1994; 23: S11–6.
  • 3. Hasturk AE, Basmaci M. Multifocal extradural and intradural eosinophilic granuloma. J Craniofac Surg 2013; 24(3): e214-6.
  • 4. Kaul R, Gupta N, Gupta S. et al. Eosinophilic granuloma of skull bone. J Cytol 2009; 26(4): 156-7
  • 5. Ghanem I, Tolo VT, D’Ambra P. et al. Langerhans cell histiocytosis of bone in children and adolescents. J Pediatr Orthop 2003; 23(1): 124-30.
  • 6. Kitsoulis PV, Paraskevas G, Vrettakos A. et al. A case of eosinophilic granuloma of the skull in an adult man: a case report. Cases J 2009;2: 9144.
  • 7. Park SH, Park J, Hwang JH. et al. Eosinophilic granuloma of the skull: a retrospective analysis. Pediatr Neurosurg 2007; 43(2): 97-101.
  • 8. Bhat S, Nazir P, Bashir H. et al. Clinicopathological pattern of cranial unifocal Langerhans cell histiocytosis: A study at medical college hospital. Indian J Med Pediatr Oncol 2015; 36(3): 183-5.
  • 9. Okamoto K, Ito J, Furusawa T. et al. Imaging of calvarial eosinophil granuloma. Neuroradiol 1999; 41(10): 723-8.

A Case of Calvarial Eosinophilic Granuloma Mimicking A Metastatic Tumor in an Adult Patient

Year 2017, Volume: 6 Issue: 1, 37 - 39, 01.04.2017

Abstract

Langerhans cell histiocytosis LCH , a subgroup of eosinophilic granuloma, is a rare disease that mostly affects bones. It is especially seen in children and it is uncommon in adults. Therefore, there is not adequate clinical trial about characteristic radiographic or clinical features of eosinophilic granulomas in adults. In the region of vertex, it was revealed a hard mass, in a 50 year old patients that presents with complaints of headache, dizziness and imbalance to our department, The mass located under the skin and was in 2x 5 cm diameters. In radiological images was detected an intracranial mass in anterior of the left parietal region of skull. The mass destructed the skull at the vertex level and expanded to subcutaneous and intracranial regions. There was heterogeneous enhancement in mass. There was also dural thickening and reactive enhancement. There was not any parenchymal involvement. The patient hospitalized with the diagnosis of calvarial metastasis and the lesion removed totally. Pathologycal examination disclosed an eosinophilic granuloma. As a result, eosinophilic granuloma should also be considered when in the diagnosis of calvarial lesions

References

  • 1. Alexiou GA, Mpairamidis E, Sfakianos G. et al. Cranial unifocal Langerhans cell histiocytosis in children. J Pediatr Surg 2009; 44(3): 571-4.
  • 2. Broadvent V, Egeler RM, Nesbit ME Jr. Langerhans cell histiocytosis: clinical and epidemiological aspects. Br J Cancer suppl 1994; 23: S11–6.
  • 3. Hasturk AE, Basmaci M. Multifocal extradural and intradural eosinophilic granuloma. J Craniofac Surg 2013; 24(3): e214-6.
  • 4. Kaul R, Gupta N, Gupta S. et al. Eosinophilic granuloma of skull bone. J Cytol 2009; 26(4): 156-7
  • 5. Ghanem I, Tolo VT, D’Ambra P. et al. Langerhans cell histiocytosis of bone in children and adolescents. J Pediatr Orthop 2003; 23(1): 124-30.
  • 6. Kitsoulis PV, Paraskevas G, Vrettakos A. et al. A case of eosinophilic granuloma of the skull in an adult man: a case report. Cases J 2009;2: 9144.
  • 7. Park SH, Park J, Hwang JH. et al. Eosinophilic granuloma of the skull: a retrospective analysis. Pediatr Neurosurg 2007; 43(2): 97-101.
  • 8. Bhat S, Nazir P, Bashir H. et al. Clinicopathological pattern of cranial unifocal Langerhans cell histiocytosis: A study at medical college hospital. Indian J Med Pediatr Oncol 2015; 36(3): 183-5.
  • 9. Okamoto K, Ito J, Furusawa T. et al. Imaging of calvarial eosinophil granuloma. Neuroradiol 1999; 41(10): 723-8.
There are 9 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

M Arif Aladağ This is me

Alpay Alkan This is me

Neşe Karadağ This is me

Publication Date April 1, 2017
Published in Issue Year 2017 Volume: 6 Issue: 1

Cite

APA Aladağ, M. A., Alkan, A., & Karadağ, N. (2017). Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu. Annals of Health Sciences Research, 6(1), 37-39.
AMA Aladağ MA, Alkan A, Karadağ N. Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu. Ann Health Sci Res. April 2017;6(1):37-39.
Chicago Aladağ, M Arif, Alpay Alkan, and Neşe Karadağ. “Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu”. Annals of Health Sciences Research 6, no. 1 (April 2017): 37-39.
EndNote Aladağ MA, Alkan A, Karadağ N (April 1, 2017) Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu. Annals of Health Sciences Research 6 1 37–39.
IEEE M. A. Aladağ, A. Alkan, and N. Karadağ, “Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu”, Ann Health Sci Res, vol. 6, no. 1, pp. 37–39, 2017.
ISNAD Aladağ, M Arif et al. “Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu”. Annals of Health Sciences Research 6/1 (April 2017), 37-39.
JAMA Aladağ MA, Alkan A, Karadağ N. Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu. Ann Health Sci Res. 2017;6:37–39.
MLA Aladağ, M Arif et al. “Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu”. Annals of Health Sciences Research, vol. 6, no. 1, 2017, pp. 37-39.
Vancouver Aladağ MA, Alkan A, Karadağ N. Erişkin Bir Hastada Metastatik Tümörü Taklit Eden Kalvarial Eosinofilik Granülom Olgusu. Ann Health Sci Res. 2017;6(1):37-9.