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Antik Anadolu’da nadir bir patoloji: Legg-Calvé-Perthes hastalığı

Year 2021, , 49 - 58, 28.12.2021
https://doi.org/10.33613/antropolojidergisi.936560

Abstract

Legg-Calvé-Perthes hastalığı (LCP) 1909 ve 1990 yıllarında Legg, Calvé, Perthes ve Waldenström tarafından bağımsız olarak tanımlanan ve femur başının mantar şeklini almasıyla sonuçlanan patolojidir. Etiyolojisi tam olarak bilinmemekle birlikte genetik ve çevresel faktörlerin etkili olduğu düşünülmektedir. Çocukluk yıllarında ortaya çıkan bu patoloji bireyin yaşamı boyunca etkili olmakta ve ilerleyen yaşla birlikte porognoz seviyesi artmaktadır. Görülme sıklığı erkek bireylerde daha fazladır. Araştırmacılar, LCP’nin genellikle unilateral görüldüğünü ancak nadiren de olsa bilateral örneklerin de olduğunu belirtmektedir. Çalışmada, Bizans dönemi MTR toplumuna ait ileri erişkin kadın bireyde tespit edilen LCP’nin femur ve asetabulum üzerinde bırakmış olduğu etkiler araştırılmıştır. Bireyin sol femurunda görülen bu patoloji femur başı ve asetabulumda ileri derecede osteofit oluşumlarına neden olmuştur. Femur boynunun kısalması, femur gövdesinin incelmesi, gövde boyun açısının daralması, fovea capitisin yok olması LCP etkisiyle femurda meydana gelen bariz morfolojik değişikliklerdir. Ayrıca coxada asetabulum da ileri derecede etkilenmiş, oldukça daralmış ve femur kendisine yeni bir yüzey oluşturmuştur. Femur ve asetabulumdan alınan osteometrik ölçümler femur ve asetabulumdaki morfolojik değişikliği desteklemektedir. Ancak bireyin ayak bilek kemikleri ile tibia kemikleri LCP’den kaynaklanan duruş ve yürüme bozukluğundan etkilenmemiştir. LCP Antik Dönem toplumlarında oldukça nadir görülmektedir. Bu durum Antik Anadolu toplumları için de geçerlidir. Bu çalışma Antik Anadolu toplumları ile ilgili literatüre katkı sağlaması açısından önemlidir.

References

  • Açıkkol, A., Yılmaz, H., Baykara, İ. ve Şahin, S. (2003). Kütahya Ağızören iskeletlerinin paleoantropolojik analizi ve Tunç Çağı Anadolu halkları arasındaki yeri. Antropoloji, (17), 1-26. https://doi.org/10.1501/antro_0000000211
  • Açıkkol Yıldırım, A. ve Gözlük Kırmızıoğlu, P. (2019). Legg-Calve-Perthes hastalığı: Paleopatolojik bir bakış. Sivas Cumhuriyet Üniversitesi Edebiyat Fakültesi Sosyal Bilimler Dergisi, 43(2), 1-8.
  • Berger, E., Chen, L., Sun, Z., ve Sun, Z. (2016). A probable case of Legg-Calvé-Perthes disease in Warring States-era China. International Journal of Paleopathology, 16, 27-30. https://doi.org/10.1016/j.ijpp.2016.11.001
  • Brothwell, D. R. (1981). Digging up bones. BAS Printers.
  • Byrne, D. P., Mulhall, K. J., ve Baker, J. F. (2010). Anatomy & biomechanics of the hip. The Open Sports Medicine Journal, 4, 51-57. https://doi.org/10.2174/1874387001004010051
  • Cameron, J. M. ve Izatt, M. M. (1960). Legg-Calve-Perthes’ disease. Scottish Medical Journal, 5(4), 148-154. https://doi.org/10.1177%2F003693306000500402
  • Çırak, M. T., Şarbak, A., ve Çırak, A. (2019). Sinop Kefevi Nekropolü (MTR) insan kalıntılarının paleodemografisine antropolojik bakış. M. Dalkılıç (Ed.) içinde, Academic studies on natural and health sciences, Volume 2 (s. 379-396). Gece Akademi. https://www.insackongre.com/_files/ugd/e42d97_19d4631675de47f2a786ef6a73c1b15e.pdf
  • Deepa, R., Shastri, D., ve Suganya, K. (2021). Morphometric analysis of acetabulum in South Indian population. International Journal of Anatomy and Research, 9(1), 7851-7856. https://doi.org/10.16965/ijar.2020.243
  • Demir, N. (2019). Legg-Calvé-Perthes hastalığı. Biruni Sağlık ve Eğitim Bilimleri Dergisi, 3, 1-13. https://dergi.biruni.edu.tr/wp-content/uploads/2019/12/4.-NECDET-DEM%C4%B0R.pdf
  • Herrerin, J., ve Garralda, M. D. (2012). Legg–Calvé–Perthes disease and unifocal eosinophilic granuloma in a Visigoth from the Duratón Necropolis (Segovia, Spain). International Journal of Osteoarchaeology, 22(1), 86-97. https://doi.org/10.1002/oa.1189
  • Herring, J. A., Neustadt, J. B., Williams, J. J., Early, J. S., ve Browne, R. H. (1992). The lateral pillar classification of Legg-Calvé-Perthes disease. Journal of Pediatric Orthpaedics, 12(2), 143-150. https://doi.org/10.1097/01241398-199203000-00001
  • Herring, J. A., Kim, H. T., ve Browne, R. (2004). Legg-Calvé-Perthes disease. Part I: Classification of radiographs with use of the modified lateral pillar and Stulberg classifications. The Journal of Bone & Joint Surgery, 86(10), 2103–2120. https://doi.org/10.2106/00004623-200410000-00001
  • Huhnstock, S., Svenningsen, S., Merckoll, E., Catterall, A., Terjesen, T., ve Wiig, O. (2017). Radiographic classifications in Perthes Disease. Acta Orthopaedica, 88(5), 522-529. https://doi.org/10.1080/17453674.2017.1340040
  • Kaur, H., ve Jit, I. (1990). Age estimation from cortical index of the human clavicle in Northwest Indians. American Journal of Physical Antropology, 83(3), 297-305. https://doi.org/10.1002/ajpa.1330830304
  • Krogman, W. M., ve İşcan, M. Y. (1986). The human skeleton in forensic medicine, Second Edition. Charles C. Thomas Publisher.
  • Kuo, K. N., Wu, K., Smith, P. A., Shih, S., ve Altiok, H. (2011). Classification of Legg-Calvé-Perthes disease. Journal of Pediatric Orthopaedics, 31, S168-S173. https://doi.org/10.1097/BPO.0b013e318223b50e
  • Lee, S. T, Vaidy, S. V., Song, H. R, Lee, S. H., Suh, S. W., ve Telang, S. S. (2007). Bone age delay patterns in Legg-Calvé-Perthes disease: An analysis using the Tanner and Whitehouse 3 method. Journal of Pediatric Orthopaedics, 27(2), 192-203.https://doi.org/10.1097/01.bpb.0000242381.89510.e5
  • Loder, R. T., ve Skopelja, E. N. (2011). The epidemiology and demographics of Legg-Calvé-Perthes’ disease. International Scholarly Research Notices, Article ID 504393. https://doi.org/10.5402/2011/504393
  • Leroux, J., Abu Amara, S., ve Lechevallier, J. (2018). Legg-Calvé-Perthes disease. Orthopaedics & Traumatology: Surgery & Research, 104(S1), S107-S112. https://doi.org/10.1016/j.otsr.2017.04.012
  • Manzon, V. S., Ferrante, Z., Giganti, M., ve Gualdi-Russo, E. (2017). On the antiquity of Legg-Calvé-Perthes disease: Skeletal evidence in Iron Age Italy. HOMO, 68(1), 10–17. https://doi.org/10.1016/j.jchb.2016.11.002
  • Muratlı, H. H. ve Özdemir, H. (2017). Legg-Calvé-Perthes hastalığının klinik ve radyolojik değerlendirilmesi ve direkt radyografi temelli sınıflama sistemleri. TOTBİD Dergisi, 16, 10–16. https://doi.org/10.14292/totbid.dergisi.2017.03
  • Olivier, G. (1969). Practical anthropology. Charles C. Thomson.
  • Ortner, D. J. (2003). Identification of pathological conditions in human skeletal remains, 2nd edition. Academic Press.
  • Pasupathy B., Babu S., ve Sathish, M. (2019). Validation of Catterall classification in the management of Legg-Calve-Perthes disease. International Journal of Paediatric Orthopaedics, 5(1), 20-24. http://ijpoonline.com/wp-content/uploads/2019/01/9.-IJPO-Jan-April-2019-Article_71_IJPO_2018.pdf
  • Pick, J. W., Stack, J. K., ve Anson, B. J. (1941). Measurements on the human femur - I. Lengths, diameters and angles. Quarterly Bulletin of the Northwestern University Medical School, 15(4), 281-290. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3802358/
  • Pillai, T. J., Devi, C. K. L., ve Devi, S. T. (2014). Osteometric studies on human femurs. IOSR Journal of Dental and Medical Sciences, 13(1), 2279-0861. https://doi.org/10.9790/0853-13213439
  • Ponce, P., ve Novellino, P. (2014). A Palaeopathological example of Legg-Calvé-Perthes disease from Argentina. International Journal of Paleopathology, 6, 30–33. https://doi.org/10.1016/j.ijpp.2014.03.004
  • Roberts, C., ve Cox, M. (2003). Health and disease in Britain: From prehistory to the present day. Sutton Publishing.
  • Schoenecker, P. L., ve Clohisy, J. C. (2018). Combined periacetabular and proximal femoral osteotomies for healed Perthes, R. C. Hamdy ve N. Saran (Ed.) içinde, Pediatric pelvic and proximal femoral osteotomies (s. 367-377). Springer International Publishing AG. https://doi.org/10.1007/978-3-319-78033-7_37
  • Sevim, A., Pehlevan, C., Açıkkol, A., Yılmaz, H., ve Güleç, E. (2002). Karagündüz Erken Demir Çağı iskeletleri. Arkeometri Sonuçları Toplantısı, 17, 37-48. http://www.kulturvarliklari.gov.tr/sempozyum_pdf/arkeometri/17_arkeometri.pdf
  • Smrcka, V., Marik, I., Svenssonova, M., ve Likovsky, J. (2009). Legg-Calvé-Perthes disease in Czech archaeological material. Clinical Orthopaedics and Related Researh, 467(1), 293-297. https://doi.org/10.1007/s11999-008-0527-6
  • Stulberg, S. D., Cooperman, D. R. ve Wallensten, R. (1981). The natural history of Legg-Calvé-Perthes disease. The Journal of Bone & Joint Surgery, 63(7), 1095-1108. https://doi.org/10.2106/00004623-198163070-00006
  • Şahin, S. (2019). Dilkaya (Orta Çağ) insanlarının sağlık yapısı. Antropoloji, 37, 50-71. https://doi.org/10.33613/antropolojidergisi.517217
  • Timonov, P., Fasova, A., Badiani, K., Radoinova, D., ve Alexandrov, A. (2015). Sex determination from the femur in a Bulgarian modern population. Anil Aggrawal’s Internet Journal of Forensic Medicine and Toxicology, 16(2). http://anilaggrawal.com/ij/vol_016_no_002/papers/paper001.html.
  • Ubelaker, D. H. (1978). Human skeletal remains: Excavation, analysis, interpretation. Aldine Publishing Company.
  • White, D. T., Black, M. T., ve Folkens, P. (2012). Human osteology, 3rd edition. Academic Press.
  • Workshop of European Anthropologists (1980). Recommendations for age and sex diagnoses of Skeletons. Journal of Human Evolution, 9(7), 517-549. https://doi.org/10.1016/0047-2484(80)90061-5

A rare pathology in ancient Anatolia: Legg-Calvé-Perthes disease

Year 2021, , 49 - 58, 28.12.2021
https://doi.org/10.33613/antropolojidergisi.936560

Abstract

Legg-Calvé-Perthes disease (LCP) is a pathology that has been independently defined by Legg, Calvé, Perthes and Waldenström in 1909 and 1990, resulting in a fungal shape of the femoral head. Although its etiology is not known exactly, genetic and environmental factors are thought to be effective. This pathology, which occurs in childhood, is effective throughout the life of the individual and the level of porognosis increases with the advancing age. Its incidence is higher in male individuals. Researchers state that LCP is usually seen unilateral, but rarely bilateral samples are also present. In the study, the effects of LCP on femur and acetebulum, which were detected in the advanced adult female individual belonging to the Byzantine period MTR society, were investigated. The shortening of the femoral neck, the thinning of the femoral body, the narrowing of the femur neck angle, the disappearance of the fovea capitis are obvious morphological changes in the femur due to LCP effect. Additionally, in the coxa, acetabulum is also severely affected, it got narrowed considerably and the femur formed a new surface for itself. Anthropometric measurements taken from the femur and acetabulum support the morphological changes in the femur and acetabulum. However, tarsal, metatarsal and tibia bones of the individual were not affected by the posture and gait disturbance caused by LCP. LCP is very rare in ancient populations. This situation is also valid for ancient Anatolian populations. This study is important in terms of contributing to the literature about ancient Anatolian populations.

References

  • Açıkkol, A., Yılmaz, H., Baykara, İ. ve Şahin, S. (2003). Kütahya Ağızören iskeletlerinin paleoantropolojik analizi ve Tunç Çağı Anadolu halkları arasındaki yeri. Antropoloji, (17), 1-26. https://doi.org/10.1501/antro_0000000211
  • Açıkkol Yıldırım, A. ve Gözlük Kırmızıoğlu, P. (2019). Legg-Calve-Perthes hastalığı: Paleopatolojik bir bakış. Sivas Cumhuriyet Üniversitesi Edebiyat Fakültesi Sosyal Bilimler Dergisi, 43(2), 1-8.
  • Berger, E., Chen, L., Sun, Z., ve Sun, Z. (2016). A probable case of Legg-Calvé-Perthes disease in Warring States-era China. International Journal of Paleopathology, 16, 27-30. https://doi.org/10.1016/j.ijpp.2016.11.001
  • Brothwell, D. R. (1981). Digging up bones. BAS Printers.
  • Byrne, D. P., Mulhall, K. J., ve Baker, J. F. (2010). Anatomy & biomechanics of the hip. The Open Sports Medicine Journal, 4, 51-57. https://doi.org/10.2174/1874387001004010051
  • Cameron, J. M. ve Izatt, M. M. (1960). Legg-Calve-Perthes’ disease. Scottish Medical Journal, 5(4), 148-154. https://doi.org/10.1177%2F003693306000500402
  • Çırak, M. T., Şarbak, A., ve Çırak, A. (2019). Sinop Kefevi Nekropolü (MTR) insan kalıntılarının paleodemografisine antropolojik bakış. M. Dalkılıç (Ed.) içinde, Academic studies on natural and health sciences, Volume 2 (s. 379-396). Gece Akademi. https://www.insackongre.com/_files/ugd/e42d97_19d4631675de47f2a786ef6a73c1b15e.pdf
  • Deepa, R., Shastri, D., ve Suganya, K. (2021). Morphometric analysis of acetabulum in South Indian population. International Journal of Anatomy and Research, 9(1), 7851-7856. https://doi.org/10.16965/ijar.2020.243
  • Demir, N. (2019). Legg-Calvé-Perthes hastalığı. Biruni Sağlık ve Eğitim Bilimleri Dergisi, 3, 1-13. https://dergi.biruni.edu.tr/wp-content/uploads/2019/12/4.-NECDET-DEM%C4%B0R.pdf
  • Herrerin, J., ve Garralda, M. D. (2012). Legg–Calvé–Perthes disease and unifocal eosinophilic granuloma in a Visigoth from the Duratón Necropolis (Segovia, Spain). International Journal of Osteoarchaeology, 22(1), 86-97. https://doi.org/10.1002/oa.1189
  • Herring, J. A., Neustadt, J. B., Williams, J. J., Early, J. S., ve Browne, R. H. (1992). The lateral pillar classification of Legg-Calvé-Perthes disease. Journal of Pediatric Orthpaedics, 12(2), 143-150. https://doi.org/10.1097/01241398-199203000-00001
  • Herring, J. A., Kim, H. T., ve Browne, R. (2004). Legg-Calvé-Perthes disease. Part I: Classification of radiographs with use of the modified lateral pillar and Stulberg classifications. The Journal of Bone & Joint Surgery, 86(10), 2103–2120. https://doi.org/10.2106/00004623-200410000-00001
  • Huhnstock, S., Svenningsen, S., Merckoll, E., Catterall, A., Terjesen, T., ve Wiig, O. (2017). Radiographic classifications in Perthes Disease. Acta Orthopaedica, 88(5), 522-529. https://doi.org/10.1080/17453674.2017.1340040
  • Kaur, H., ve Jit, I. (1990). Age estimation from cortical index of the human clavicle in Northwest Indians. American Journal of Physical Antropology, 83(3), 297-305. https://doi.org/10.1002/ajpa.1330830304
  • Krogman, W. M., ve İşcan, M. Y. (1986). The human skeleton in forensic medicine, Second Edition. Charles C. Thomas Publisher.
  • Kuo, K. N., Wu, K., Smith, P. A., Shih, S., ve Altiok, H. (2011). Classification of Legg-Calvé-Perthes disease. Journal of Pediatric Orthopaedics, 31, S168-S173. https://doi.org/10.1097/BPO.0b013e318223b50e
  • Lee, S. T, Vaidy, S. V., Song, H. R, Lee, S. H., Suh, S. W., ve Telang, S. S. (2007). Bone age delay patterns in Legg-Calvé-Perthes disease: An analysis using the Tanner and Whitehouse 3 method. Journal of Pediatric Orthopaedics, 27(2), 192-203.https://doi.org/10.1097/01.bpb.0000242381.89510.e5
  • Loder, R. T., ve Skopelja, E. N. (2011). The epidemiology and demographics of Legg-Calvé-Perthes’ disease. International Scholarly Research Notices, Article ID 504393. https://doi.org/10.5402/2011/504393
  • Leroux, J., Abu Amara, S., ve Lechevallier, J. (2018). Legg-Calvé-Perthes disease. Orthopaedics & Traumatology: Surgery & Research, 104(S1), S107-S112. https://doi.org/10.1016/j.otsr.2017.04.012
  • Manzon, V. S., Ferrante, Z., Giganti, M., ve Gualdi-Russo, E. (2017). On the antiquity of Legg-Calvé-Perthes disease: Skeletal evidence in Iron Age Italy. HOMO, 68(1), 10–17. https://doi.org/10.1016/j.jchb.2016.11.002
  • Muratlı, H. H. ve Özdemir, H. (2017). Legg-Calvé-Perthes hastalığının klinik ve radyolojik değerlendirilmesi ve direkt radyografi temelli sınıflama sistemleri. TOTBİD Dergisi, 16, 10–16. https://doi.org/10.14292/totbid.dergisi.2017.03
  • Olivier, G. (1969). Practical anthropology. Charles C. Thomson.
  • Ortner, D. J. (2003). Identification of pathological conditions in human skeletal remains, 2nd edition. Academic Press.
  • Pasupathy B., Babu S., ve Sathish, M. (2019). Validation of Catterall classification in the management of Legg-Calve-Perthes disease. International Journal of Paediatric Orthopaedics, 5(1), 20-24. http://ijpoonline.com/wp-content/uploads/2019/01/9.-IJPO-Jan-April-2019-Article_71_IJPO_2018.pdf
  • Pick, J. W., Stack, J. K., ve Anson, B. J. (1941). Measurements on the human femur - I. Lengths, diameters and angles. Quarterly Bulletin of the Northwestern University Medical School, 15(4), 281-290. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3802358/
  • Pillai, T. J., Devi, C. K. L., ve Devi, S. T. (2014). Osteometric studies on human femurs. IOSR Journal of Dental and Medical Sciences, 13(1), 2279-0861. https://doi.org/10.9790/0853-13213439
  • Ponce, P., ve Novellino, P. (2014). A Palaeopathological example of Legg-Calvé-Perthes disease from Argentina. International Journal of Paleopathology, 6, 30–33. https://doi.org/10.1016/j.ijpp.2014.03.004
  • Roberts, C., ve Cox, M. (2003). Health and disease in Britain: From prehistory to the present day. Sutton Publishing.
  • Schoenecker, P. L., ve Clohisy, J. C. (2018). Combined periacetabular and proximal femoral osteotomies for healed Perthes, R. C. Hamdy ve N. Saran (Ed.) içinde, Pediatric pelvic and proximal femoral osteotomies (s. 367-377). Springer International Publishing AG. https://doi.org/10.1007/978-3-319-78033-7_37
  • Sevim, A., Pehlevan, C., Açıkkol, A., Yılmaz, H., ve Güleç, E. (2002). Karagündüz Erken Demir Çağı iskeletleri. Arkeometri Sonuçları Toplantısı, 17, 37-48. http://www.kulturvarliklari.gov.tr/sempozyum_pdf/arkeometri/17_arkeometri.pdf
  • Smrcka, V., Marik, I., Svenssonova, M., ve Likovsky, J. (2009). Legg-Calvé-Perthes disease in Czech archaeological material. Clinical Orthopaedics and Related Researh, 467(1), 293-297. https://doi.org/10.1007/s11999-008-0527-6
  • Stulberg, S. D., Cooperman, D. R. ve Wallensten, R. (1981). The natural history of Legg-Calvé-Perthes disease. The Journal of Bone & Joint Surgery, 63(7), 1095-1108. https://doi.org/10.2106/00004623-198163070-00006
  • Şahin, S. (2019). Dilkaya (Orta Çağ) insanlarının sağlık yapısı. Antropoloji, 37, 50-71. https://doi.org/10.33613/antropolojidergisi.517217
  • Timonov, P., Fasova, A., Badiani, K., Radoinova, D., ve Alexandrov, A. (2015). Sex determination from the femur in a Bulgarian modern population. Anil Aggrawal’s Internet Journal of Forensic Medicine and Toxicology, 16(2). http://anilaggrawal.com/ij/vol_016_no_002/papers/paper001.html.
  • Ubelaker, D. H. (1978). Human skeletal remains: Excavation, analysis, interpretation. Aldine Publishing Company.
  • White, D. T., Black, M. T., ve Folkens, P. (2012). Human osteology, 3rd edition. Academic Press.
  • Workshop of European Anthropologists (1980). Recommendations for age and sex diagnoses of Skeletons. Journal of Human Evolution, 9(7), 517-549. https://doi.org/10.1016/0047-2484(80)90061-5
There are 37 citations in total.

Details

Primary Language Turkish
Subjects Anatomy, Anthropology
Journal Section Research Articles
Authors

Asuman Çırak 0000-0002-0019-164X

Ayşegül Şarbak This is me 0000-0003-3199-1612

Publication Date December 28, 2021
Submission Date May 12, 2021
Acceptance Date September 17, 2021
Published in Issue Year 2021

Cite

APA Çırak, A., & Şarbak, A. (2021). Antik Anadolu’da nadir bir patoloji: Legg-Calvé-Perthes hastalığı. Anthropology(42), 49-58. https://doi.org/10.33613/antropolojidergisi.936560

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