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Parmak oranı kemik mineral yoğunluğunun biyobelirteci midir? Sivas Cumhuriyet Üniversitesi örneği

Year 2024, Issue: 49, 63 - 70, 31.12.2024
https://doi.org/10.33613/antropolojidergisi.1571455

Abstract

Bu çalışmanın amacı, parmak oranı ile kemik yoğunluğu arasında bir ilişki olup olmadığını belirleyerek, parmak oranının osteoporoz ve osteopeni gibi kemik hastalıklarına duyarlılığı gösteren bir biyolojik belirteç olma potansiyelini incelemektir. Çalışma verileri, Cumhuriyet Üniversitesi Araştırma Hastanesi Nükleer Tıp Polikliniği'ne kontrol amacıyla başvuran 100 kadın, 100 erkek olmak üzere 200 hastadan ve 50 kadın, 50 erkek 100 sağlıklı bireyden toplanmıştır. Katılımcıların kemik dansitometri ölçümleri alınırken, her iki eldeki ikinci ve dördüncü parmak uzunlukları dijital kumpas kullanılarak ölçülmüştür. Araştırma sonuçları, parmak oranı ile kemik yoğunluğu arasında pozitif bir ilişki saptandığını göstermektedir. Bu ilişki her iki cinsiyette de gözlemlenmiş olsa da, kadınlarda daha belirgin bir şekilde güçlüdür. Erkeklerde sağ el parmak oranı (2P:4P) ile sol KMY (r = 0.589), sağ 2P:4P ile sol T-skoru (r = 0.544) ve sağ 2P:4P ile sol Z-skoru (r = 0.454) arasında pozitif yönlü ilişkiler tespit edilmiştir. Benzer şekilde, sağ 2P:4P ile femoral KMY (r = 0.608), femoral T- skoru (r = 0.465) ve femoral Z-skoru (r = 0.362) arasında da anlamlı pozitif ilişkiler bulunmuştur (p < 0.05). Kadınlarda ise, sağ el parmak oranı (2P:4P) ile sol BMD (r = 0.707), sağ 2P:4P ile sol T-skoru (r = 0.815) ve sağ 2P:4P ile sol Z-skoru (r = 0.737) arasında daha güçlü pozitif ilişkiler saptanmıştır. Ayrıca sağ 2P:4P ile femoral KMY (r = 0.469), femoral T-skoru (r = 0.535) ve femoral Z-skoru (r = 0.495) arasında da benzer şekilde anlamlı ilişkiler bulunmuştur (p < 0.05). Bu bulgular, parmak oranı ile kemik yoğunluğu arasındaki ilişkinin özellikle kadınlarda daha güçlü olduğunu göstermektedir. Özetle, daha yüksek parmak oranına sahip olan bireylerin kemik yoğunluğunun daha yüksek olduğu saptanmıştır.

Ethical Statement

Hitit Üniversitesi Girişimsel Olmayan Etik Kurulu'nun 27/02/2020 tarihli kararı ve Sivas Cumhuriyet Üniversitesi Uygulama ve Araştırma Hastanesi Başhekimliği'nin 22/06/2020 izni ile veri toplama aşaması gerçekleştirilmiştir.

Supporting Institution

yoktur

Thanks

Sivas Cumhuriyet Üniversitesi Nükleer Tıp Ana Bilim Dalı Başkanı Prof. Dr. ZEKİYE HASBEK, Sivas Cumhuriyet Üniversitesi Biyoistatistik Ana Bilim Dalı öğretim elemanı Dr. Öğr. Üyesi Ziynet ÇINAR ve veri toplama aşamasında teknik destek sağlayan sağlık personeli Ayşe MOĞULKOÇ'a teşekkür ederiz.

References

  • Davis, S. R., Lambrinoudaki, I., Lumsden, M., Mishra, G. D., Pal, L., & Rees, M. (2015). Menopause. Nature Reviews Disease Primers, 1, 15004. https://doi.org/10.1038/nrdp.2015.4
  • Galis, F., Ten Broek, C. M., Van Dongen, S., & Wijnaendts, L. C. (2010). Sexual dimorphism in the prenatal digit ratio (2D:4D). Archives of Sexual Behavior, 39(1), 57–62. https://doi.org/10.1007/s10508-009-9510-4
  • Hönekopp, J., & Watson, S. (2010). Meta-analysis of digit ratio 2D:4D shows greater sex difference in the right hand. American Journal of Human Biology, 22, 619–630. https://doi.org/10.1002/ajhb.21047
  • Jiang, J., Young, K., & Pike, C. J. (2020). Second to fourth digit ratio is associated with dementia in women. Early Human Development, 149, 105152. https://doi.org/10.1016/j.earlhumdev.2020.105152
  • Keen, R. (2007). Osteoporosis: Strategies for prevention and management. Best Practice & Research Clinical Rheumatology, 21(1), 109–122. https://doi.org/10.1016/j.berh.2007.01.003
  • Lee, S. H. F., Aziz, S. A., Hamid, M., Lim, Y. C., Koh, D., & Chaw, L. L. (2021). 2D:4D ratio and autism spectrum disorder in Brunei Darussalam. Journal of Autism and Developmental Disorders, 51(12), 4577–4586. https://doi.org/10.1007/s10803-021-04899-9
  • Lu, C., Miclau, T., Hu, D., Hansen, E., Tsui, K., Puttlitz, C., & Marcucio, R. S. (2005). Cellular basis for age-related changes in fracture repair. Journal of Orthopaedic Research, 23(6), 1300–1307. https://doi.org/10.1016/j.orthres.2005.02.009
  • Manning, J. T., & Fink, B. (2011). Digit ratio and aggregate personality scores across nations: Data from the BBC internet study. Personality and Individual Differences, 51(4), 387–391. https://doi.org/10.1016/j.paid.2010.05.040
  • Manning, J. T., & Fink, B. (2020). Understanding COVID-19: Digit ratio and sex differences in national case fatality rates. Early Human Development, 146, 105074. https://doi.org/10.1016/j.earlhumdev.2020.105074
  • Manning, J. T., Churchill, A. J. G., & Peters, M. (2007). The effects of sex, ethnicity, and sexual orientation on self-measured digit ratio (2D:4D). Archives of Sexual Behavior, 36, 223–233. https://doi.org/10.1007/s10508-006-9144-3
  • Manning, J. T., Fink, B., Mason, L., & Trivers, R. (2021). Digit ratio and body mass index in the BBC internet study: Prenatal sex steroids and a Trivers-Willard effect on body composition. Journal of Biosocial Science, 53(6), 1–10. https://doi.org/10.1017/S0021932021000390
  • Miller, P. D., & Zapalowski, C. (2011). Bone mineral density measurements. In The Osteoporosis Primer (pp. 262–276). https://doi.org/10.1017/CBO9780511545795.020
  • Ratti, C., Vulcano, E., Canton, G., Marano, M., Murena, L., & Cherubino, P. (2013). Factors affecting bone strength other than osteoporosis. Aging Clinical and Experimental Research, 25(1 Suppl.), 9–11. https://doi.org/10.1007/s40520-013-0098-6
  • Tao, L., Wu, R., Song, X., Xia, M., & Yao, R. (2023). The associations between 2D:4D ratio and behavior problems among Chinese preschool children: A cross-sectional study. Early Human Development, 186, 105871. https://doi.org/10.1016/j.earlhumdev.2023.105871
  • Xu, X., Yekeen, T. A., Xiao, Q., Wang, Y., Lu, F., & Huo, X. (2013). Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste. Environmental Pollution, 182, 63–69. https://doi.org/10.1016/j.envpol.2013.07.024
  • Yaman, A., Özdemir, O., Gök, Ş. (2024). Evaluation of the Relationships Between Bone Mineral Density and Anthropometric Measurements in Women with Postmenopausal Osteoporosis. Türk Osteoporoz Dergisi, 30(1), 16-21. https://doi:10.4274/tod.galenos.2023.54036.

Is digit ratio a biomarker of bone mineral density? Sivas Cumhuriyet University example

Year 2024, Issue: 49, 63 - 70, 31.12.2024
https://doi.org/10.33613/antropolojidergisi.1571455

Abstract

This study aimed to investigate the relationship between bone mineral density (BMD) and digit ratio, with the goal of evaluating the potential of digit ratio as a marker for predicting osteoporosis-type bone diseases. The study sample included 200 patients (100 women and 100 men) who visited the Nuclear Medicine Clinic at Cumhuriyet University Research Hospital for check-ups, along with a control group of 100 healthy individuals (50 women and 50 men). Bone densitometry measurements were obtained for all participants, and the lengths of the second and fourth digits on both hands were measured using digital calipers. The results indicated a positive correlation between digit ratio and BMD, with this relationship being more pronounced in women. In men, significant positive correlations were found between the right-hand digit ratio and left BMD (r = 0.589), the right digit ratio and left T-score (r = 0.544), and the right digit ratio and left Z-score (r = 0.454). Similar positive associations were observed between the right digit ratio and femoral BMD (r = 0.608), femoral T-score (r = 0.465), and femoral Z-score (r = 0.362) (p < 0.05). For women, stronger positive correlations were identified between the right-hand digit ratio and left BMD (r = 0.707), the right digit ratio and left T-score (r = 0.815), and the right digit ratio and left Z-score (r = 0.737). Additionally, significant associations were noted between the right digit ratio and femoral BMD (r = 0.469), femoral T-score (r = 0.535), and femoral Z-score (r = 0.495) (p < 0.05). These findings suggest that the association between digit ratio and bone mineral density is stronger in women. In summary, individuals with a high digit ratio generally have higher bone density.

Ethical Statement

Hitit Üniversitesi Girişimsel Olmayan Etik Kurulu'nun 27/02/2020 tarihli kararı ve Sivas Cumhuriyet Üniversitesi Uygulama ve Araştırma Hastanesi Başhekimliği'nin 22/06/2020 izni ile veri toplama aşaması gerçekleştirilmiştir.

Thanks

Sivas Cumhuriyet Üniversitesi Nükleer Tıp Ana Bilim Dalı Başkanı Prof. Dr. ZEKİYE HASBEK, Sivas Cumhuriyet Üniversitesi Biyoistatistik Ana Bilim Dalı öğretim elemanı Dr. Öğr. Üyesi Ziynet ÇINAR ve veri toplama aşamasında teknik destek sağlayan sağlık personeli Ayşe MOĞULKOÇ'a teşekkür ederiz.

References

  • Davis, S. R., Lambrinoudaki, I., Lumsden, M., Mishra, G. D., Pal, L., & Rees, M. (2015). Menopause. Nature Reviews Disease Primers, 1, 15004. https://doi.org/10.1038/nrdp.2015.4
  • Galis, F., Ten Broek, C. M., Van Dongen, S., & Wijnaendts, L. C. (2010). Sexual dimorphism in the prenatal digit ratio (2D:4D). Archives of Sexual Behavior, 39(1), 57–62. https://doi.org/10.1007/s10508-009-9510-4
  • Hönekopp, J., & Watson, S. (2010). Meta-analysis of digit ratio 2D:4D shows greater sex difference in the right hand. American Journal of Human Biology, 22, 619–630. https://doi.org/10.1002/ajhb.21047
  • Jiang, J., Young, K., & Pike, C. J. (2020). Second to fourth digit ratio is associated with dementia in women. Early Human Development, 149, 105152. https://doi.org/10.1016/j.earlhumdev.2020.105152
  • Keen, R. (2007). Osteoporosis: Strategies for prevention and management. Best Practice & Research Clinical Rheumatology, 21(1), 109–122. https://doi.org/10.1016/j.berh.2007.01.003
  • Lee, S. H. F., Aziz, S. A., Hamid, M., Lim, Y. C., Koh, D., & Chaw, L. L. (2021). 2D:4D ratio and autism spectrum disorder in Brunei Darussalam. Journal of Autism and Developmental Disorders, 51(12), 4577–4586. https://doi.org/10.1007/s10803-021-04899-9
  • Lu, C., Miclau, T., Hu, D., Hansen, E., Tsui, K., Puttlitz, C., & Marcucio, R. S. (2005). Cellular basis for age-related changes in fracture repair. Journal of Orthopaedic Research, 23(6), 1300–1307. https://doi.org/10.1016/j.orthres.2005.02.009
  • Manning, J. T., & Fink, B. (2011). Digit ratio and aggregate personality scores across nations: Data from the BBC internet study. Personality and Individual Differences, 51(4), 387–391. https://doi.org/10.1016/j.paid.2010.05.040
  • Manning, J. T., & Fink, B. (2020). Understanding COVID-19: Digit ratio and sex differences in national case fatality rates. Early Human Development, 146, 105074. https://doi.org/10.1016/j.earlhumdev.2020.105074
  • Manning, J. T., Churchill, A. J. G., & Peters, M. (2007). The effects of sex, ethnicity, and sexual orientation on self-measured digit ratio (2D:4D). Archives of Sexual Behavior, 36, 223–233. https://doi.org/10.1007/s10508-006-9144-3
  • Manning, J. T., Fink, B., Mason, L., & Trivers, R. (2021). Digit ratio and body mass index in the BBC internet study: Prenatal sex steroids and a Trivers-Willard effect on body composition. Journal of Biosocial Science, 53(6), 1–10. https://doi.org/10.1017/S0021932021000390
  • Miller, P. D., & Zapalowski, C. (2011). Bone mineral density measurements. In The Osteoporosis Primer (pp. 262–276). https://doi.org/10.1017/CBO9780511545795.020
  • Ratti, C., Vulcano, E., Canton, G., Marano, M., Murena, L., & Cherubino, P. (2013). Factors affecting bone strength other than osteoporosis. Aging Clinical and Experimental Research, 25(1 Suppl.), 9–11. https://doi.org/10.1007/s40520-013-0098-6
  • Tao, L., Wu, R., Song, X., Xia, M., & Yao, R. (2023). The associations between 2D:4D ratio and behavior problems among Chinese preschool children: A cross-sectional study. Early Human Development, 186, 105871. https://doi.org/10.1016/j.earlhumdev.2023.105871
  • Xu, X., Yekeen, T. A., Xiao, Q., Wang, Y., Lu, F., & Huo, X. (2013). Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste. Environmental Pollution, 182, 63–69. https://doi.org/10.1016/j.envpol.2013.07.024
  • Yaman, A., Özdemir, O., Gök, Ş. (2024). Evaluation of the Relationships Between Bone Mineral Density and Anthropometric Measurements in Women with Postmenopausal Osteoporosis. Türk Osteoporoz Dergisi, 30(1), 16-21. https://doi:10.4274/tod.galenos.2023.54036.
There are 16 citations in total.

Details

Primary Language English
Subjects Anthropometry
Journal Section Research Articles
Authors

Fırat Koç 0000-0002-8558-6308

Timur Gültekin 0000-0003-3520-5308

Publication Date December 31, 2024
Submission Date October 21, 2024
Acceptance Date December 18, 2024
Published in Issue Year 2024 Issue: 49

Cite

APA Koç, F., & Gültekin, T. (2024). Is digit ratio a biomarker of bone mineral density? Sivas Cumhuriyet University example. Anthropology(49), 63-70. https://doi.org/10.33613/antropolojidergisi.1571455

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