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The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee
Abstract
In order to produce early gonarthrosis in rabbits we injected Sulphur-35 (100 mg/kg) which is diluted in carboxymethlyl cellulose suspension. Then we investigated the histopathological changes and PGE-2, LTB-4 levels of the joint hyalin cartilage. The normal value of cartilage tissue PGE-2 and LTB-4 whick was taken from the rabbits knee joint are LTB-4=O.3±0.009 ng/gr and PGE 2=9.6+0. 4 mg/gr. In the samples of the knee joints cartilage tissue which carboxymethlyl cellulose was being injected we found the value of LTB-4 and PGE-2 very close to the normal (LTB4=0.4 ngr/gr and PGE2=10.4 ug/gr). In early degenerativi arthritis of these rabbits, we used diclofenac sodium wash-out. We compared the results of PGE-2, LTB-4 and histopathologic al changes with the control group. In PGE-2 and LTB-4 Ievels of the knee joints injected sulphur we found a great increase when it is compared to the normal conditions (LTB-4=O.8 ng/gr and PGE-2=23.2 mg/gr) The results of wash out with Diclofenac Sodium in experimental gonarthrosis with Sulphur 35 are in 1-2 weeks LTB-4=0. 3±0.002 ng/gr and PGE-2=11.2±0.06 mg/gr and in 3-4 weeks LTB4=0.4±0.009 ng/gr and PGE-2=11.2+0.3mg/gr, we believe that diclofenac sodium can be used in arthroscopic wash out fluid in early gonarthrosis.
Keywords
Details
Primary Language
English
Subjects
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Journal Section
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Publication Date
September 11, 2006
Submission Date
March 6, 2014
Acceptance Date
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Published in Issue
Year 1990 Volume: 24 Number: 5
APA
Doral, M., & Sener, E. (2006). The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica, 24(5), 337-340. https://doi.org/10.3944/aott.v24i5.1178
AMA
1.Doral M, Sener E. The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica. 2006;24(5):337-340. doi:10.3944/aott.v24i5.1178
Chicago
Doral, Mahmut, and Ertugrul Sener. 2006. “The Use of Diclofenac Sodium in Arthroscopic Wash-Out Fluid in Experimental Gonarthrosis in Rabbit Knee”. Acta Orthopaedica et Traumatologica Turcica 24 (5): 337-40. https://doi.org/10.3944/aott.v24i5.1178.
EndNote
Doral M, Sener E (September 1, 2006) The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica 24 5 337–340.
IEEE
[1]M. Doral and E. Sener, “The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee”, Acta Orthopaedica et Traumatologica Turcica, vol. 24, no. 5, pp. 337–340, Sept. 2006, doi: 10.3944/aott.v24i5.1178.
ISNAD
Doral, Mahmut - Sener, Ertugrul. “The Use of Diclofenac Sodium in Arthroscopic Wash-Out Fluid in Experimental Gonarthrosis in Rabbit Knee”. Acta Orthopaedica et Traumatologica Turcica 24/5 (September 1, 2006): 337-340. https://doi.org/10.3944/aott.v24i5.1178.
JAMA
1.Doral M, Sener E. The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica. 2006;24:337–340.
MLA
Doral, Mahmut, and Ertugrul Sener. “The Use of Diclofenac Sodium in Arthroscopic Wash-Out Fluid in Experimental Gonarthrosis in Rabbit Knee”. Acta Orthopaedica et Traumatologica Turcica, vol. 24, no. 5, Sept. 2006, pp. 337-40, doi:10.3944/aott.v24i5.1178.
Vancouver
1.Mahmut Doral, Ertugrul Sener. The use of Diclofenac sodium in arthroscopic wash-out fluid in experimental gonarthrosis in rabbit knee. Acta Orthopaedica et Traumatologica Turcica. 2006 Sep. 1;24(5):337-40. doi:10.3944/aott.v24i5.1178