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Spor hekimliğinde gen tedavisi

Year 1997, Volume: 31 Issue: 5, 502 - 505, 11.09.2006

Christian Latermann Semih Gur Paul Robbins Christopher Evans

https://izlik.org/JA32JS24PK

Abstract

Yaralanmaya uğrayan yumuşak dokunun iyileşmesi için gerekli hücresel yanıtların herbirisi PDGF, TGF-B, bFGF, IGF-I, BMP-2 gibi. "growth factor" diye adlandırılan spesifik proteinler tarafından kontrol edilirler. Dışarıdan uygulanabilen bu faktörlerin yenilenme ömrü son derece kısa olduğu için viral taşıyıcı-larla, gen tedavisi gündeme gelmiştir. Gen tedavisinin en büyük etkinliği potansiyel olarak etkilenen dokulara sürekli growth faktör taşıyıcılarının verilmesidir. Bu derleme ile özetlendiği üzere hayvanlar üzerinde ya-pılan çalışmalar ve insan araştırmalarının ilk klinik sonuçları bu tekniğin spor yaralanmalarının tedavisinde kullanılabileceğini ortaya koymaktadır.

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Gene therapy in sports medicine

Year 1997, Volume: 31 Issue: 5, 502 - 505, 11.09.2006

Christian Latermann Semih Gur Paul Robbins Christopher Evans

https://izlik.org/JA32JS24PK

Abstract

Injured soft tissues trigger a cellular response which is necessary for recovery and regulated by specific proteins, namely growth factors like PDGF, TGF-B, BFGF, IGF-1 and BMP-2. Application of these factors via external route is not possible because of the very short half-life time. Thus, gene therapy with virus vectors is now being discussed to provide continuous growth factors. As briefly summarized in this review article experiments on animals and early results of clinical work and research demonstrate that it can be used in the treatment of sports injuries.

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Details

Primary Language English
Authors

Christian Latermann This is me

Semih Gur This is me

Paul Robbins This is me

Christopher Evans This is me

Publication Date September 11, 2006
DOI https://doi.org/10.3944/aott.v31i5.4257
IZ https://izlik.org/JA32JS24PK
Published in Issue Year 1997 Volume: 31 Issue: 5

Cite

APA Latermann, C., Gur, S., Robbins, P., & Evans, C. (2006). Gene therapy in sports medicine. Acta Orthopaedica et Traumatologica Turcica, 31(5), 502-505. https://doi.org/10.3944/aott.v31i5.4257
AMA 1.Latermann C, Gur S, Robbins P, Evans C. Gene therapy in sports medicine. Acta Orthopaedica et Traumatologica Turcica. 2006;31(5):502-505. doi:10.3944/aott.v31i5.4257
Chicago Latermann, Christian, Semih Gur, Paul Robbins, and Christopher Evans. 2006. “Gene Therapy in Sports Medicine”. Acta Orthopaedica et Traumatologica Turcica 31 (5): 502-5. https://doi.org/10.3944/aott.v31i5.4257.
EndNote Latermann C, Gur S, Robbins P, Evans C (September 1, 2006) Gene therapy in sports medicine. Acta Orthopaedica et Traumatologica Turcica 31 5 502–505.
IEEE [1]C. Latermann, S. Gur, P. Robbins, and C. Evans, “Gene therapy in sports medicine”, Acta Orthopaedica et Traumatologica Turcica, vol. 31, no. 5, pp. 502–505, Sept. 2006, doi: 10.3944/aott.v31i5.4257.
ISNAD Latermann, Christian - Gur, Semih - Robbins, Paul - Evans, Christopher. “Gene Therapy in Sports Medicine”. Acta Orthopaedica et Traumatologica Turcica 31/5 (September 1, 2006): 502-505. https://doi.org/10.3944/aott.v31i5.4257.
JAMA 1.Latermann C, Gur S, Robbins P, Evans C. Gene therapy in sports medicine. Acta Orthopaedica et Traumatologica Turcica. 2006;31:502–505.
MLA Latermann, Christian, et al. “Gene Therapy in Sports Medicine”. Acta Orthopaedica et Traumatologica Turcica, vol. 31, no. 5, Sept. 2006, pp. 502-5, doi:10.3944/aott.v31i5.4257.
Vancouver 1.Latermann C, Gur S, Robbins P, Evans C. Gene therapy in sports medicine. Acta Orthopaedica et Traumatologica Turcica [Internet]. 2006 Sept. 1;31(5):502-5. Available from: https://izlik.org/JA32JS24PK