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Preventive effect of low molecular weight heparin on thrombosis formation in microvascular anastomosis

Year 1996, Volume: 30 Issue: 2, 183 - 185, 11.09.2006

Oguz Ozdemir Erhan Coskunol Zeki Ozcan Gulcin Basdemir

Abstract

Antithrombotic effect of the low molecular weight heparin (L.M.W.H) in microvascular anastomosis was investigated with femoral arteries of the rats. Femoral arteries of 28 rats were cut and anastomosed end to end with microsurgical technique. Rats were divided into two groups and 0.0004 ml/ 100 gr/daily (0.1 axa/U/gr/daily) L.M.W.H. was given to the first group for 7 days and in the second group nothing was given. At the 15 th day all the anastomosis were examined clinically and pathologically, In the first group which had given L.M.W.H. and in the second group, there was no thrombosis formation and arterial flow was normal. As a result, we concluded that it is not necessary to give L.M.W.H. after microvascular anastomosis, when there is no endothelial damage and which have repaired with a good microsurgical technique.

Keywords

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Düşük molekül ağırlıklı heparinin mikrovasküler anastomozlarda tromboz önleyici etkisi (Deneysel çalışma)

Year 1996, Volume: 30 Issue: 2, 183 - 185, 11.09.2006

Oguz Ozdemir Erhan Coskunol Zeki Ozcan Gulcin Basdemir

Abstract

Mikrovasküler anastomoz sonrası Düşük Molekül Ağırlıklı Heparin'in (D.M.A.H.) antitrombotik etkisi sıçanlarda femoral arter anastomozu yapilip deneysel olarak araştırılmıştır. Yirmisekiz sıçanın femoral arteri kesilerek mikrocerrahi teknikle uç uca anastomoz yapılmıştır. Sıçanlar iki gruba ayrılarak, 1. gruba anastomozdan sonra 7 gün süreyle 0.0004 ml/100 gr/gün (0,1axa U/gr/gün) düz D.M.A.H. subkutan olarak uygulandı. 2. gruba ise herhangi bir antitrombotik ajan verilmedi. Bütün anastomozlar 15. günde klinik ve patolojik olarak incelendi. D.M.A.H uygulanan ve uygulanmayan bütün sıçanlarda mikrovasküler anastomoz bölgesinde trombüs oluşmadığı ve arteriel akımın normal olduğu gözlendi. Endotel hasarı meydana gelmemiş ve tekniğe uygun olarak yapılan mikro arteriyel anastomozlarda, her zaman D.M.A.H. kullanmaya gerek olmadığı sonucuna varıldı.

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Details

Primary Language English
Journal Section Experimental Study
Authors

Oguz Ozdemir This is me

Erhan Coskunol This is me

Zeki Ozcan This is me

Gulcin Basdemir This is me

Publication Date September 11, 2006
Published in Issue Year 1996 Volume: 30 Issue: 2

Cite

APA Ozdemir, O., Coskunol, E., Ozcan, Z., Basdemir, G. (2006). Preventive effect of low molecular weight heparin on thrombosis formation in microvascular anastomosis. Acta Orthopaedica Et Traumatologica Turcica, 30(2), 183-185. https://doi.org/10.3944/aott.v30i2.1936
AMA Ozdemir O, Coskunol E, Ozcan Z, Basdemir G. Preventive effect of low molecular weight heparin on thrombosis formation in microvascular anastomosis. Acta Orthopaedica et Traumatologica Turcica. September 2006;30(2):183-185. doi:10.3944/aott.v30i2.1936
Chicago Ozdemir, Oguz, Erhan Coskunol, Zeki Ozcan, and Gulcin Basdemir. “Preventive Effect of Low Molecular Weight Heparin on Thrombosis Formation in Microvascular Anastomosis”. Acta Orthopaedica Et Traumatologica Turcica 30, no. 2 (September 2006): 183-85. https://doi.org/10.3944/aott.v30i2.1936.
EndNote Ozdemir O, Coskunol E, Ozcan Z, Basdemir G (September 1, 2006) Preventive effect of low molecular weight heparin on thrombosis formation in microvascular anastomosis. Acta Orthopaedica et Traumatologica Turcica 30 2 183–185.
IEEE O. Ozdemir, E. Coskunol, Z. Ozcan, and G. Basdemir, “Preventive effect of low molecular weight heparin on thrombosis formation in microvascular anastomosis”, Acta Orthopaedica et Traumatologica Turcica, vol. 30, no. 2, pp. 183–185, 2006, doi: 10.3944/aott.v30i2.1936.
ISNAD Ozdemir, Oguz et al. “Preventive Effect of Low Molecular Weight Heparin on Thrombosis Formation in Microvascular Anastomosis”. Acta Orthopaedica et Traumatologica Turcica 30/2 (September 2006), 183-185. https://doi.org/10.3944/aott.v30i2.1936.
JAMA Ozdemir O, Coskunol E, Ozcan Z, Basdemir G. Preventive effect of low molecular weight heparin on thrombosis formation in microvascular anastomosis. Acta Orthopaedica et Traumatologica Turcica. 2006;30:183–185.
MLA Ozdemir, Oguz et al. “Preventive Effect of Low Molecular Weight Heparin on Thrombosis Formation in Microvascular Anastomosis”. Acta Orthopaedica Et Traumatologica Turcica, vol. 30, no. 2, 2006, pp. 183-5, doi:10.3944/aott.v30i2.1936.
Vancouver Ozdemir O, Coskunol E, Ozcan Z, Basdemir G. Preventive effect of low molecular weight heparin on thrombosis formation in microvascular anastomosis. Acta Orthopaedica et Traumatologica Turcica. 2006;30(2):183-5.