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The repair of articular cartilage defects with lyophilized collagen (Experimental study in rabbits)

Year 1997, Volume: 31 Issue: 1, 41 - 43, 11.09.2006

Osman Calpur Seref Aktas Gulara Huseyinova Gulhan Aktas

Abstract

The purpose of this study was to compare the chondrogenic potentials of free periost grafts and lyophilized collagen. 3.2 mm diameter defects were made in the articular surfaces of both femora. Free periosteal graft from ipsilateral tibia was transplanted to the left side, whereas, the defect in the right side was filled with lyophilized collagen. Histologic and Electronmicroscopic examinations were done at three weeks. Histologic and Electronmicroscopic examinations of the left side revealed chondrogenesis in the cambium layer of the periosteum. In the right side after the organization of the granulation tissue around the lyophilized collagen multipotential fibroblastic cells differentiated to chondrocytes and so, young cartilage tissue was formed in this side. In the repair of articular cartilage defects the use of lyophilized collagen is an alternative and possible better way than free periosteal graft. But further biomechanic studies must be done to advocate the histologic and electronmicroscopic results.

Keywords

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Eklem kıkırdak defektlerinin liyofilize kollajen ile onarımı (Tavşanlarda deneysel çalışma)

Year 1997, Volume: 31 Issue: 1, 41 - 43, 11.09.2006

Osman Calpur Seref Aktas Gulara Huseyinova Gulhan Aktas

Abstract

Bu çalışmada serbest periost grefti ile liyofilize kollajenin kondro]enik potansiyelleri araştırıldı. Her iki femur distal eklem yüzeylerinde oluşturulan 3.2 mm çapında kıkırdak defektlerinden sol taraftakine aynı taraf tibia kemiğinden alınan serbest periost grefti transplante edilirken sağ distal femur eklem yüzeyindeki defekt liyofil-ize kollajen ile dolduruldu. 3. haftada yapılan histolojik ve elektron mikroskopik incelemelerde; sol tarafta periostun kambium tabakasında kondrogenezis görülürken, sağ tarafta liyofilize kollajenin etrafında organize olan granulasyon dokusu görüldü. Sağ tarafta multipotansiyel fibroblastik hücrelerin kondrositlere diferensiye olduğu ve böylece kıkırdak dokusunun geliştiği saptandı. Bu bulgularla liyofilize kollajenin eklem kıkırdak defektlerinin onarımında serbest periost uygulamasına göre daha iyi bir alternatif yöntem olacağı sonucuna varmak-la birlikte; bu konunun biomekanik çalışmalarla da desteklenmesi gerektiğini düşünmekteyiz.

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Details

Primary Language English
Journal Section Experimental Study
Authors

Osman Calpur This is me

Seref Aktas This is me

Gulara Huseyinova This is me

Gulhan Aktas This is me

Publication Date September 11, 2006
Published in Issue Year 1997 Volume: 31 Issue: 1

Cite

APA Calpur, O., Aktas, S., Huseyinova, G., Aktas, G. (2006). The repair of articular cartilage defects with lyophilized collagen (Experimental study in rabbits). Acta Orthopaedica Et Traumatologica Turcica, 31(1), 41-43. https://doi.org/10.3944/aott.v31i1.4218
AMA Calpur O, Aktas S, Huseyinova G, Aktas G. The repair of articular cartilage defects with lyophilized collagen (Experimental study in rabbits). Acta Orthopaedica et Traumatologica Turcica. September 2006;31(1):41-43. doi:10.3944/aott.v31i1.4218
Chicago Calpur, Osman, Seref Aktas, Gulara Huseyinova, and Gulhan Aktas. “The Repair of Articular Cartilage Defects With Lyophilized Collagen (Experimental Study in Rabbits)”. Acta Orthopaedica Et Traumatologica Turcica 31, no. 1 (September 2006): 41-43. https://doi.org/10.3944/aott.v31i1.4218.
EndNote Calpur O, Aktas S, Huseyinova G, Aktas G (September 1, 2006) The repair of articular cartilage defects with lyophilized collagen (Experimental study in rabbits). Acta Orthopaedica et Traumatologica Turcica 31 1 41–43.
IEEE O. Calpur, S. Aktas, G. Huseyinova, and G. Aktas, “The repair of articular cartilage defects with lyophilized collagen (Experimental study in rabbits)”, Acta Orthopaedica et Traumatologica Turcica, vol. 31, no. 1, pp. 41–43, 2006, doi: 10.3944/aott.v31i1.4218.
ISNAD Calpur, Osman et al. “The Repair of Articular Cartilage Defects With Lyophilized Collagen (Experimental Study in Rabbits)”. Acta Orthopaedica et Traumatologica Turcica 31/1 (September 2006), 41-43. https://doi.org/10.3944/aott.v31i1.4218.
JAMA Calpur O, Aktas S, Huseyinova G, Aktas G. The repair of articular cartilage defects with lyophilized collagen (Experimental study in rabbits). Acta Orthopaedica et Traumatologica Turcica. 2006;31:41–43.
MLA Calpur, Osman et al. “The Repair of Articular Cartilage Defects With Lyophilized Collagen (Experimental Study in Rabbits)”. Acta Orthopaedica Et Traumatologica Turcica, vol. 31, no. 1, 2006, pp. 41-43, doi:10.3944/aott.v31i1.4218.
Vancouver Calpur O, Aktas S, Huseyinova G, Aktas G. The repair of articular cartilage defects with lyophilized collagen (Experimental study in rabbits). Acta Orthopaedica et Traumatologica Turcica. 2006;31(1):41-3.