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Gelişimsel kalça displazili bebeklerde kalça eklem kapsülü ve ligamentum kapitis femoriste östrojen reseptörlerinin saptanması

Year 2013, Volume: 47 Issue: 3, 158 - 161, 11.06.2013

Abstract

Amaç: Çalışmamızın amacı insan kalça eklem kapsülü ve ligamentum capitis femorislerindeki östrojen reseptörü varlığını saptamaktı.
Çalışma planı: Gelişimsel kalça displazisi (GKD) nedeniyle ameliyat edilen 15 hastanın ve kontrol grubu olarak da 15 intrauterin ölü fetüsün toplam 30 kalçasından ligamentum capitis femoris (LCF) ve kalça eklem kapsülü biyopsileri alındı. Olguların cerrahi sırasında ortalama yaşı 10.3 (dağılım: 6-18) ay idi. Tam kat 1x1 cm anterior kapsül ve LCF örnekleri biyopsi olarak alındı. Kalça eklem kapsülü ve LCF’de bulunan hedef östrojen hücrelerinin oranını saptamak için monoklonal östrojen reseptör antikorları kullanılarak immünohistokimyasal bir çalışma yapıldı.
Bulgular: Kontrol grubundaki LCF örneklerinde saptanan östrojen reseptörü (ÖR) boyanma oranı 1.6±0.2%, kalça eklem kapsülünde ise 1.3±0.2% idi. GKD bulunan grupta ise LCF örneklerinde saptanan ÖR boyanma oranı 2.5±0.3% , kalça eklem kapsülünde ise 2.0±0.3% idi. LCF ve kalça eklem kapsülünde ÖR boyanma oranının kontrol grubunda GKD bulunan gruba göre istatistiksel olarak anlamlı şekilde az olduğu gözlendi (p<0.001). Her iki grupta da, kalça eklem kapsülündeki ÖR boyanma oranı LCF’dekine göre anlamlı derecede düşüktü (p<0.01).
Çıkarımlar: Ligamentum kapitis femoris ve kalça eklem kapsülünde yüksek oranda bulunan östrojen reseptörleri, GKD’nin etiyolojisinde östrojenin etkisini destekler niteliktedir.

References

  • Carter CO, Wilkinson JA. Genetic and environmental factors in the etiology of congenital dislocation of the hip. Clin Orthop Relat Res 1964;(33):119-28.
  • Dunn PM. Prenatal observation on the etiology of congenital dislocation of the hip. Clin Orthop Relat Res 1976;(119):11-22.
  • Wilkinson JA. Prime factors in the etiology of congenital dislocation of the hip. J Bone Joint Surg Br 1963;45:268-83.
  • Wynne-Davies R. Acetabular dysplasia and familial joint laxity: two etiological factors in congenital dislocation of the hip. A review of 589 patients and their families. J Bone Joint Surg Br 1970;52:704-16.
  • Suzuki S, Yamamuro T. Correlation of fetal posture and congenital dislocation of the hip. Acta Orthop Scand 1986;57:81-4.
  • Akeson WH, Woo SL, Amiel D, Doty DH, Rutherford L. Value of 17beta-oestradiol in prevention of contracture formation. Ann Rheum Dis 1975;35:429-36.
  • Liu SH, Al-Shaikh RA, Panossian V, Finerman GA, Lane JM. Estrogen affects the cellular metabolism of the anterior cruciate ligament. A potential explanation for female athletic injury. Am J Sports Med 1997;25:704-9.
  • Brenner RM, West NB, McClellan MC. Estrogen and progestin receptors in the reproductive tract of male and female primates. Biol Reprod 1990;42:11-9.
  • Aarskog D, Stoa KF, Thorsen T. Urinary oestrogen excretion in newborn infants with congenital dislocation of the hip joint. Acta Paediatr Scand 1966;55:394-7.
  • Andren L, Borglin NE. Disturbed urinary excretion pattern of oestrogens in newborns with congenital dislocation of the hip. The excretion of oestrogen during the first few days of life. Acta Endocrinol (Copenh) 1961;37:423-6.
  • Andersson JE, Vogel I, Uldbjerg N. Serum 17 beta-estradiol in newborn and neonatal hip instability. J Pediatr Orthop 2002;22:88-91.
  • Nakamura Y, Hirano S, Suzuki K, Seki K, Sagara T, Nishida T. Signaling mechanism of TGFβ1-induced collagen contraction mediated by bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci 2003;44:4331-6.
  • Diaz-Chavez J, Hernandez-Pando R, Lambert FP, Gariglio P. Down-regulation of transforming growth factor-beta type II receptor (TGF-betaRII) protein and mRNA expression in cervical cancer. Mol Cancer 2008;7:3.
  • Shynlova O, Mitchell JA, Tsampalieros A, Langille BL, Lye SJ. Progesterone and gravidity differentially regulate expression of extracellular matrix components in the pregnant rat myometrium. Biol Reprod 2004;70:986-92.
  • Fischer GM, Swain ML. Effect of sex hormones on blood pressure and vascular connective tissue in castrated and noncastrated male rats. Am J Physiol 1977;232:617-21.
  • Hama H, Yamamuro T, Takeda T. Experimental studies on connective tissue of the capsular ligament. Influences of aging and sex hormones. Acta Orthop Scand 1976;47:473-9. Shikata J, Sanada H, Tamamuro T, Takeda T. Experimental studies of the elastic fiber of the capsular ligament: influence of aging and sex hormones on the hip joint capsule of rats. Connect Tissue Res 1979;7:21-7.
  • Yamamuro T, Hama H, Takeda T, Shikata J, Sanada H. Biomechanical and hormonal factors in the etiology of congenital dislocation of the hip joint. Int Orthop 1977;1:231-6.

Estrogen receptors in hip joint capsule and ligamentum capitis femoris of babies with

Year 2013, Volume: 47 Issue: 3, 158 - 161, 11.06.2013

Abstract

Objective: The aim of this study was to detect the incidence of estrogen receptors in human hip joint capsule and ligamentum teres.
Methods: The study included biopsies of the ligamentum capitis femoris (LCF) and hip joint capsule from 15 patients undergoing hip surgery for developmental dysplasia of the hip (DDH) and from the control hips of 15 cases of intrauterine fetal death. Mean age was 10.3 (range: 6 to 18) months at the time of surgery. Full-thickness 1x1 cm anterior capsule and LCF portions were taken as biopsy specimens. An immunohistochemical study using monoclonal antibody against estrogen receptors was performed to identify the rate of target estrogen cells in the hip joint capsule and LCF.
Results: Estrogen receptor (ER) staining rates were 1.6±0.2% for the LCF and 1.3±0.2% for the hip joint capsule in the control groups, and 2.5±0.3% for the LCF and 2.0±0.3% for the hip joint capsule in the DDH groups. Estrogen receptor staining rates in the LCF and hip joint capsule control groups were significantly lower than that in the DDH groups (p<0.001). In both groups, ER rates were significantly lower in the hip joint capsule than in the LCF (p<0.01).
Conclusion: The high rate of ERs in the LCF and hip joint capsule appears to support the effect of estrogen in the etiology of the DDH.

References

  • Carter CO, Wilkinson JA. Genetic and environmental factors in the etiology of congenital dislocation of the hip. Clin Orthop Relat Res 1964;(33):119-28.
  • Dunn PM. Prenatal observation on the etiology of congenital dislocation of the hip. Clin Orthop Relat Res 1976;(119):11-22.
  • Wilkinson JA. Prime factors in the etiology of congenital dislocation of the hip. J Bone Joint Surg Br 1963;45:268-83.
  • Wynne-Davies R. Acetabular dysplasia and familial joint laxity: two etiological factors in congenital dislocation of the hip. A review of 589 patients and their families. J Bone Joint Surg Br 1970;52:704-16.
  • Suzuki S, Yamamuro T. Correlation of fetal posture and congenital dislocation of the hip. Acta Orthop Scand 1986;57:81-4.
  • Akeson WH, Woo SL, Amiel D, Doty DH, Rutherford L. Value of 17beta-oestradiol in prevention of contracture formation. Ann Rheum Dis 1975;35:429-36.
  • Liu SH, Al-Shaikh RA, Panossian V, Finerman GA, Lane JM. Estrogen affects the cellular metabolism of the anterior cruciate ligament. A potential explanation for female athletic injury. Am J Sports Med 1997;25:704-9.
  • Brenner RM, West NB, McClellan MC. Estrogen and progestin receptors in the reproductive tract of male and female primates. Biol Reprod 1990;42:11-9.
  • Aarskog D, Stoa KF, Thorsen T. Urinary oestrogen excretion in newborn infants with congenital dislocation of the hip joint. Acta Paediatr Scand 1966;55:394-7.
  • Andren L, Borglin NE. Disturbed urinary excretion pattern of oestrogens in newborns with congenital dislocation of the hip. The excretion of oestrogen during the first few days of life. Acta Endocrinol (Copenh) 1961;37:423-6.
  • Andersson JE, Vogel I, Uldbjerg N. Serum 17 beta-estradiol in newborn and neonatal hip instability. J Pediatr Orthop 2002;22:88-91.
  • Nakamura Y, Hirano S, Suzuki K, Seki K, Sagara T, Nishida T. Signaling mechanism of TGFβ1-induced collagen contraction mediated by bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci 2003;44:4331-6.
  • Diaz-Chavez J, Hernandez-Pando R, Lambert FP, Gariglio P. Down-regulation of transforming growth factor-beta type II receptor (TGF-betaRII) protein and mRNA expression in cervical cancer. Mol Cancer 2008;7:3.
  • Shynlova O, Mitchell JA, Tsampalieros A, Langille BL, Lye SJ. Progesterone and gravidity differentially regulate expression of extracellular matrix components in the pregnant rat myometrium. Biol Reprod 2004;70:986-92.
  • Fischer GM, Swain ML. Effect of sex hormones on blood pressure and vascular connective tissue in castrated and noncastrated male rats. Am J Physiol 1977;232:617-21.
  • Hama H, Yamamuro T, Takeda T. Experimental studies on connective tissue of the capsular ligament. Influences of aging and sex hormones. Acta Orthop Scand 1976;47:473-9. Shikata J, Sanada H, Tamamuro T, Takeda T. Experimental studies of the elastic fiber of the capsular ligament: influence of aging and sex hormones on the hip joint capsule of rats. Connect Tissue Res 1979;7:21-7.
  • Yamamuro T, Hama H, Takeda T, Shikata J, Sanada H. Biomechanical and hormonal factors in the etiology of congenital dislocation of the hip joint. Int Orthop 1977;1:231-6.
There are 17 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Engin Desteli This is me

Ahmet Piskin This is me

Ali Birol Gülman This is me

Figen Kaymaz This is me

Bulent Koksal This is me

Murat Erdogan This is me

Publication Date June 11, 2013
Published in Issue Year 2013 Volume: 47 Issue: 3

Cite

APA Desteli, E., Piskin, A., Gülman, A. B., Kaymaz, F., et al. (2013). Estrogen receptors in hip joint capsule and ligamentum capitis femoris of babies with. Acta Orthopaedica Et Traumatologica Turcica, 47(3), 158-161.
AMA Desteli E, Piskin A, Gülman AB, Kaymaz F, Koksal B, Erdogan M. Estrogen receptors in hip joint capsule and ligamentum capitis femoris of babies with. Acta Orthopaedica et Traumatologica Turcica. June 2013;47(3):158-161.
Chicago Desteli, Engin, Ahmet Piskin, Ali Birol Gülman, Figen Kaymaz, Bulent Koksal, and Murat Erdogan. “Estrogen Receptors in Hip Joint Capsule and Ligamentum Capitis Femoris of Babies With”. Acta Orthopaedica Et Traumatologica Turcica 47, no. 3 (June 2013): 158-61.
EndNote Desteli E, Piskin A, Gülman AB, Kaymaz F, Koksal B, Erdogan M (June 1, 2013) Estrogen receptors in hip joint capsule and ligamentum capitis femoris of babies with. Acta Orthopaedica et Traumatologica Turcica 47 3 158–161.
IEEE E. Desteli, A. Piskin, A. B. Gülman, F. Kaymaz, B. Koksal, and M. Erdogan, “Estrogen receptors in hip joint capsule and ligamentum capitis femoris of babies with”, Acta Orthopaedica et Traumatologica Turcica, vol. 47, no. 3, pp. 158–161, 2013.
ISNAD Desteli, Engin et al. “Estrogen Receptors in Hip Joint Capsule and Ligamentum Capitis Femoris of Babies With”. Acta Orthopaedica et Traumatologica Turcica 47/3 (June 2013), 158-161.
JAMA Desteli E, Piskin A, Gülman AB, Kaymaz F, Koksal B, Erdogan M. Estrogen receptors in hip joint capsule and ligamentum capitis femoris of babies with. Acta Orthopaedica et Traumatologica Turcica. 2013;47:158–161.
MLA Desteli, Engin et al. “Estrogen Receptors in Hip Joint Capsule and Ligamentum Capitis Femoris of Babies With”. Acta Orthopaedica Et Traumatologica Turcica, vol. 47, no. 3, 2013, pp. 158-61.
Vancouver Desteli E, Piskin A, Gülman AB, Kaymaz F, Koksal B, Erdogan M. Estrogen receptors in hip joint capsule and ligamentum capitis femoris of babies with. Acta Orthopaedica et Traumatologica Turcica. 2013;47(3):158-61.