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Mechanical strength of antibiotic-loaded bone cement: A biomechanical study with Cemex bone cement, teicoplanin and tobramycin

Year 1997, Volume: 31 Issue: 3, 245 - 249, 11.09.2006

Abstract

We used tobramycin due to its broad-spectrum, and teicoplanin due to its effectivity against resistant Gram-positive organisms to investigate the effect of antibiotics on the mechanical properties of bone cement. We added 0.5g, 1g, 2g, 3g and 4g of either teicoplanin (Targocid ¨, Hoechst) or tobramycin (nonsterile powder, Lilly) to Cemex bone cement and measured its compressive strength according to the standards set by the American Society for Testing and Materials (ASTM, F 451-95). For each antibiotic concentration in each group, cement was polymerized in special molds providing us with test specimens which were cylinders 12 mm high and 6 mm in diameter. One group contained no antibiotics and served as the control group. Compressive strengths were 98±7 MPa in the control group; 94±7 MPa for 0.5g, 92±7 MPa for 1g, 86±5 MPa for 2g, 78±8 MPa for 3g, 58±9 MPa for 4g in the teicoplanin group; 95±5 MPa for 0.5g; 88±8 MPa for 1g; 86±7 MPa for 2g; 85±9 MPa for 3g; 80±11 MPa for 4Êg in the tobramycin group. Compressive strength was above the minimum standard in all groups except teicoplanin with an antibiotic concentration of 4Êg/40g cement. 1, 2, 3 and 4g specimens also had a statistically significant weakening in mechanical strength when compared to the control group. When mixed according to the method described, addition of up to 2 grams of teicoplanin or tobramycin to Cemex bone cement neither weakens its compressive strength nor alters its handling characteristics substantially.

Antibiyotikli kemik çimentosunun mekanik dayanımı: Cemex kemik çimentosu, teikoplanin ve tobramisin ile biyomekanik çalışma

Year 1997, Volume: 31 Issue: 3, 245 - 249, 11.09.2006

Abstract

Geniş etki spektrumu nedeniyle tobramisin, dirençli Grampozitif organizmalara etkisi nedeniyle teikoplanin kullanarak antibiyotiklerin kemik çimentosunun mekanik dayanımı üzerine etkisini araştırdık. Cemex ke-mik çimentosuna 0.5g, 1g, 2g, 3g ve 4g Teikoplanin (Targocid ®, steril toz. Hoechst) veya aynı miktarlarda Tobramisin (steril olmayan 101. Lilly) katarak kompressif dayanımını ölçtük. Çimento özel kalıplarda dondurularak her bir antibiyotik konsantrasyonu için onbeşer adet silindir örnek hazırlandı. Antibiyotik içermeyen bir grup da kontrol grubunu oluşturdu. Antibiyotik konsantrasyonuna göre kompressif dayanım kontrol grubunda 98±7 MPa; teikoplanin grubunda 0.5g için 94±7 MPa, 1g için 92±7 MPa, 2g için 86±5 Mpa, 3g için 78±8 MPa, 4g için 58±9 Mpa; tobramisin grubunda 0.5g için 95±5 MPa, 1g için 88±8 Mpa, 2g için 86±7 MPa, 3g için 85±9 Mpa, 4g için 80±11 MPa olarak bulundu. 4g teikoplanin içeren grup dışında tüm grup-larda kompressif dayanım Amerikan Test ve Malzemeler Cemiyeti (American Society for Testing and Materials, ASTM; F 451-95) tarafından minimum standart olarak belirlenen 70 MPa'ın üzerinde bulundu. Kontrol grubu ile karşılaştırıldığında da 0.5 g dışındaki miktarlarda mekanik dayanımda istatistiksel olarak anlamlı bir azalma saptandı. 3g ve 4g gruplarında çimentonun kullanım özelliği belirgin şekilde değişti. Tanımlanan teknikle yapılması koşuluyla, bir paket (40 g) Cemex kemik çimentosuna 2 grama kadar Teikoplanin veya Tobramisin karıştırılması çimentonun kompressif dayanımını ve kullanım özelliklerini önemli ölçüde bozmamaktadır.

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Details

Primary Language English
Journal Section Experimental Study
Authors

S. Goksan This is me

Nadir Sener This is me

İ. Tozun This is me

M. Goksan This is me

Publication Date September 11, 2006
Published in Issue Year 1997 Volume: 31 Issue: 3

Cite

APA Goksan, S., Sener, N., Tozun, İ., Goksan, M. (2006). Mechanical strength of antibiotic-loaded bone cement: A biomechanical study with Cemex bone cement, teicoplanin and tobramycin. Acta Orthopaedica Et Traumatologica Turcica, 31(3), 245-249. https://doi.org/10.3944/aott.v31i3.2139
AMA Goksan S, Sener N, Tozun İ, Goksan M. Mechanical strength of antibiotic-loaded bone cement: A biomechanical study with Cemex bone cement, teicoplanin and tobramycin. Acta Orthopaedica et Traumatologica Turcica. September 2006;31(3):245-249. doi:10.3944/aott.v31i3.2139
Chicago Goksan, S., Nadir Sener, İ. Tozun, and M. Goksan. “Mechanical Strength of Antibiotic-Loaded Bone Cement: A Biomechanical Study With Cemex Bone Cement, Teicoplanin and Tobramycin”. Acta Orthopaedica Et Traumatologica Turcica 31, no. 3 (September 2006): 245-49. https://doi.org/10.3944/aott.v31i3.2139.
EndNote Goksan S, Sener N, Tozun İ, Goksan M (September 1, 2006) Mechanical strength of antibiotic-loaded bone cement: A biomechanical study with Cemex bone cement, teicoplanin and tobramycin. Acta Orthopaedica et Traumatologica Turcica 31 3 245–249.
IEEE S. Goksan, N. Sener, İ. Tozun, and M. Goksan, “Mechanical strength of antibiotic-loaded bone cement: A biomechanical study with Cemex bone cement, teicoplanin and tobramycin”, Acta Orthopaedica et Traumatologica Turcica, vol. 31, no. 3, pp. 245–249, 2006, doi: 10.3944/aott.v31i3.2139.
ISNAD Goksan, S. et al. “Mechanical Strength of Antibiotic-Loaded Bone Cement: A Biomechanical Study With Cemex Bone Cement, Teicoplanin and Tobramycin”. Acta Orthopaedica et Traumatologica Turcica 31/3 (September 2006), 245-249. https://doi.org/10.3944/aott.v31i3.2139.
JAMA Goksan S, Sener N, Tozun İ, Goksan M. Mechanical strength of antibiotic-loaded bone cement: A biomechanical study with Cemex bone cement, teicoplanin and tobramycin. Acta Orthopaedica et Traumatologica Turcica. 2006;31:245–249.
MLA Goksan, S. et al. “Mechanical Strength of Antibiotic-Loaded Bone Cement: A Biomechanical Study With Cemex Bone Cement, Teicoplanin and Tobramycin”. Acta Orthopaedica Et Traumatologica Turcica, vol. 31, no. 3, 2006, pp. 245-9, doi:10.3944/aott.v31i3.2139.
Vancouver Goksan S, Sener N, Tozun İ, Goksan M. Mechanical strength of antibiotic-loaded bone cement: A biomechanical study with Cemex bone cement, teicoplanin and tobramycin. Acta Orthopaedica et Traumatologica Turcica. 2006;31(3):245-9.