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Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model

, - , 03.06.2016

Abstract

Objective: To evaluate the efficacy of gene enhanced tissue engineering followed mosaicplasty in a goat model expecting to find a suitable method for the clinical larger osteochondral restoration. Methods: An acute cylindrical defect 9 mm in diameter was created in the weight bearing area of the medial femoral condyle in a goat model. Thirty-six medial femoral condyles were divided into 6 groups using different proportion of gene enhanced tissue engineering and mosaicplasty to restore the defects. The specimen received gross and histology observation, which was evaluated by the histological grading scale of O'Driscoll, Keeley and Salter. Transmission electron microscope observation was also performed. Two factors analysis of variance and Student-Newman-Kewls test were used to compare the specimen. Results: The gross and histology observation revealed that each defects of six groups had different restoration. The scores of the reparative tissue of three groups were significantly higher than those in other three groups. Conclusion: Gene enhanced tissue engineering followed mosaicplasty could restore a 9 mm diameter osteochondral defects in a goat model effectively. With the reduction of covering area of the graft, the advantages of the combined gene enhanced tissue engineering method can be better reflected.

 

DOI: 10.3944/AOTT.2016.15.0427
This abstract belongs to the un-edited version of the article and is only for informative purposes. Published version may differ from the current version.

, - , 03.06.2016

Abstract

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Details

Primary Language English
Journal Section Experimental Study
Authors

Jun Sun This is me

Xiao-kui Hou This is me

Yu-xin Zheng This is me

Publication Date June 3, 2016
Published in Issue

Cite

APA Sun, J., Hou, X.-k., & Zheng, Y.-x. (2016). Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model. Acta Orthopaedica Et Traumatologica Turcica.
AMA Sun J, Hou Xk, Zheng Yx. Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model. Acta Orthopaedica et Traumatologica Turcica. Published online June 1, 2016.
Chicago Sun, Jun, Xiao-kui Hou, and Yu-xin Zheng. “Restore a 9 Mm Diameter Osteochondral Defect With Gene Enhanced Tissue Engineering Followed Mosaicplasty in a Goat Model”. Acta Orthopaedica Et Traumatologica Turcica, June (June 2016).
EndNote Sun J, Hou X-k, Zheng Y-x (June 1, 2016) Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model. Acta Orthopaedica et Traumatologica Turcica
IEEE J. Sun, X.-k. Hou, and Y.-x. Zheng, “Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model”, Acta Orthopaedica et Traumatologica Turcica, June 2016.
ISNAD Sun, Jun et al. “Restore a 9 Mm Diameter Osteochondral Defect With Gene Enhanced Tissue Engineering Followed Mosaicplasty in a Goat Model”. Acta Orthopaedica et Traumatologica Turcica. June 2016.
JAMA Sun J, Hou X-k, Zheng Y-x. Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model. Acta Orthopaedica et Traumatologica Turcica. 2016.
MLA Sun, Jun et al. “Restore a 9 Mm Diameter Osteochondral Defect With Gene Enhanced Tissue Engineering Followed Mosaicplasty in a Goat Model”. Acta Orthopaedica Et Traumatologica Turcica, 2016.
Vancouver Sun J, Hou X-k, Zheng Y-x. Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model. Acta Orthopaedica et Traumatologica Turcica. 2016.