Neuroregen Scaffolding Applications in Medulla Spinalis Injuries

Year 2022, Volume: 2 Issue: 3, 50 - 53, 22.12.2022

Merve Aydın , Hıdır Pekmez

https://doi.org/10.58252/artukluder.1205685

Abstract

The medulla spinalis is a central nervous system formation that communicates sensory and motor information between the brain and the peripheral nervous system. In spinal cord injuries, this communication is disrupted, and the patient may experience loss of sensory and motor function. For the repair of the spinal cord after injury, remyelination of axons and regrowth of tracts are required in the trauma area. Scaffolds direct the regeneration of axons and accelerate the repair process of neurons. Collagens are frequently used in scaffolding studies due to their natural structure that supports cell adhesion and functions. Animal and human studies show that collagen-based neuroregen scaffolds provide significant sensory and motor gains. Such gains are promising in spinal cord injuries, one of the major causes of morbidity and mortality worldwide. In this review, we aimed to examine medulla spinalis injuries, their mechanism, and post-injury neuroregenerative scaffold applications.

Keywords

Collagen, Neuroregen scaffolds, Spinal cord injury

Medulla Spinalis Yaralanmalarında Nörorejen İskele Uygulamaları

Abstract

Medulla spinalis duyu ve motor bilgilerin beyin ile çevresel sinir sistemi arasındaki iletişimini sağlayan merkezi sinir sistemine ait bir oluşumdur. Spinal kord yaralanmalarında bu iletişim bozularak hastada duyu ve/veya motor işlev kayıpları ortaya çıkabilmektedir. Yaralanma sonrası medulla spinalisin onarımı için travma bölgesinde aksonların remiyelinizasyonları ve traktusların yeniden büyümesi gerekmektedir. İskeleler aksonların rejenerasyonunu yönlendirip nöronların onarım sürecini hızlandırmaktadır. Kolajenler, hücre adezyonunu ve işlevlerini destekleyen doğal yapısı nedeniyle iskele çalışmalarında sıklıkla kullanılmaktadır. Yapılan hayvan ve insan çalışmaları kolajen temelli nörorejen iskelelerin duyusal ve motor düzeyde anlamlı kazanımlar sağladığını göstermektedir. Dünya çapında önemli morbidite ve mortalite nedenlerinden olan spinal kord yaralanmalarında bu gibi kazanımlar umut vericidir. Bu derlemede medulla spinalis yaralanmaları, mekanizması ve yaralanma sonrası nörorejen iskele uygulamalarını incelemeyi amaçladık.

Keywords

Kolajen, Nörorejen iskeleler, Spinal kord yaralanması

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