Katılma Nöbetlerinde Demir ve Pirasetam ile Anoksik Epileptik Nöbetlerde Levetirasetamın Etkinliği

Year 2023, Volume: 3 Issue: 1, 18 - 23, 12.04.2023

Nezir Özgün , Osman Akdeniz , Muhittin Çelik , Hakan Sarbay , İzzettin Toktaş

https://doi.org/10.58252/artukluder.1227442

Abstract

Giriş: Bu çalışmada, katılma nöbeti veya anoksik epileptik nöbet tanısı alan ve demir, pirasetam veya levetirasetam tedavilerinden en az biri başlanan hastalarda, ilaçların nöbetleri azaltma etkinliği değerlendirilmiştir.
Materyal and Metot: Çalışma kriterlerini karşılayan 194 hastanın dosyaları geriye dönük olarak incelenmiştir. Demir eksikliği anemisi olan veya anemi olmasa bile ferritin değeri 12 ng/dl altında olan hastalara demir tedavisi başlanmıştı. Anemi, düşük ferritin ve anoksik epileptik nöbeti olmayan hastalara pirasetam, anoksik epileptik nöbeti olanlara levetirasetam başlanmıştı.
Bulgular: Hastaların 108’i (% 55.7) erkekti. Ortalama yaş 21.39±12.78 aydı. 87 hastaya demir tedavisi, 96 hastaya pirasetam ve 11 hastaya levetirasetam başlanmıştı. Tedavi başlandıktan bir ay sonraki değerlendirmede tüm gruplarda nöbet sayısı belirgin azalmıştı (p<0.05).
Sonuç: Tüm gruplarda nöbet sayısının azaldığını veya tam durduğunu saptadık. Levetirasetam katılma nöbeti sonrası gelişen anoksik epileptik nöbetlerde oldukça etkili gibi görünmektedir.

Keywords

Katılma nöbeti, Anoksik epileptik nöbet, Tedavi

Supporting Institution

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Project Number

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Thanks

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The Efficacy of Iron and Piracetam in Breath Holding Spells and Levetiracetam in Anoxic Epileptic Seizures

Abstract

Introduction: In this study, the patients diagnosed with breath holding spell (BHS) or anoxic epileptic seizures and initiated at least one out of iron or piracetam or levetiracetam therapies were evaluated.
Material and Methods: We retrospectively evaluated 194 BHS patients. Iron therapy was initiated in case of iron deficiency anemia or case of ferritin values under 12 ng/dl even if there was no anemia. The patients having no iron deficiency anemia, low ferritin and anoxic epileptic seizures were administered piracetam and the patients diagnosed with anoxic epileptic seizures were administered levetiracetam.
Results: One hundred and eight patients (55.7%) were male. The mean age was 21.39±12.78 months. Iron therapy was initiated in 87 patients, piracetam to 96, and levetiracetam in 11 patients. Seizure numbers were manifestly decreased in all groups by the end of the first month after treatment concerning pretreatment levels (p<0.05).
Conclusions: We determined that the spells were reduced or completely stopped in all groups. Levetiracetam seems to be considerably effective in patients developing anoxic epileptic seizures after BHS.

Keywords

Breath holding spell, Anoxic epileptic seizure, Treatment

Project Number

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