Investigation of Blood Natural Killer Cell Activity in Normozoospermic Fertile, Oligozoospermic, Severe-Oligozoospermic, Oligoastenozoospermic, Azoospermic and Idiopathic Individuals

Year 2023, Volume: 3 Issue: 2, 218 - 221, 11.08.2023

M. Ferit Özmen Muhamet Afşin Uğur Şeker Dilek Yavuz Muhammed Hanifi Bademkıran Ümüt Cirit İbrahim Yıldırım

https://doi.org/10.58252/artukluder.1260015

Abstract

Introduction: Infertility is a health problem that negatively affects couples and society in many ways and is becoming increasingly common. It is estimated that 30-40% of these problems are caused by men. It was aimed to determine whether natural killer (Natural Killer: NK) cell activity changes in male individuals with different degrees of infertility problems and in individuals with normal sperm count and concentration (normozoospermia).
Methods: NK cell activities were measured from blood samples taken from individuals who were determined to be oligozoospermia, severe-oligozoospermia, oligoastenoozospermia, azoospermia and idiopathic as a result of semen analysis with from individuals diagnosed normozoospermia (n:120).
Results: NK cell activity in blood was observed as the lowest in normozoospermia (544.46 pg/ml), but the highest value measured in severe oligozoospermia group (1005.90 pg/ml). On the other hand, NK cell activity was measured 797.60 ± 428.55 pg/ml, 905.34 ± 430.60 pg/ml, 757.66 ± 541.16 pg/ml and 639.44 ± 385.50 pg/ml in oligozoospermia, oligoastenozoospermia, azoospermia and idiopathic groups respectively. While the difference in NK activity between the severe oligozospermia group and the other groups was significant (p<0.05), the differences between the other groups were not significant (p >0.05).
Conclusion: It was determined that NK cell activity was higher in individuals with severe oligozoospermia than normozoospermia, oligozoospermia, oligoastenozoospermia, azoospermia and idiopathic individuals.

Keywords

Infertility, NK activity, Normozoospermia, Severe oligozoospermia

Normozoospermik Fertil Bireyler ile Oligozoospermik, Şiddetli-Oligozoospermik, Oligoastenozoospermik, Azoospermik ve İdiyopatik Bireylerde Natural Killer Hücre Aktivitesinin Araştırılması

Abstract

Giriş: İnfertilite çiftleri ve toplumu birçok açıdan olumsuz etkileyen ve gittikçe yaygınlaşan bir sağlık problemidir. Bu problemlerin %30-40’ının erkek kaynaklı olduğu tahmin edilmektedir. Farklı derecelerde infertilite problemi olan erkek bireyler ile normal sperm sayısı ve konsantrasyonuna sahip bireylerde (normozoospermi) doğal öldürücü (Natural Killer: NK) hücre aktivitesinin değişip değişmediğinin belirlenmesi amaçlanmıştır.
Gereç ve Yöntem: Sperma analizleri sonucu oligozoospermi, şiddetli-oligozoospermi, oligoastenoozospermi, azoospermi ve idiopatik olduğu belirlenen bireyler ile normozoospermi teşhisi konan bireylerden (n:120) alınan kan numunelerinden NK hücre aktiviteleri ölçüldü.
Bulgular: Yapılan ölçümler sonucunda normozoospermi grubu en düşük değer (544.46 pg/ml) alırken şiddetli oligozoospermi grubundan en yüksek değer (1005.90 pg/ml) alınmıştır. NK hücre aktivitesi ise oligozoospermi, oligoastenozoospermi, azoospermi ve idiyopatik gruplarda sırasıyla 797.60 ± 428.55 pg/ml, 905.34 ± 430.60 pg/ml, 757.66 ± 541.16 pg/ml ve 639.44 ± 385.50 pg/ml olarak ölçüldü. Şiddetli oligozoospermi grubu ile diğer gruplar arasında NK aktivitesi farkı önemli (p<0.05) bulunurken diğer gruplar arasındaki farklar önemli bulunmamıştır (p >0.05).
Sonuç: İnfertilite derecesi şiddetli oligozoospermi olan bireylerde NK hücre aktivitesinin normozoospermi, oligozoospermi, oligoastenozoospermi, azoospermi ve idiopatik gruplarından daha yüksek olduğu belirlenmiştir.

Keywords

İnfertilite, NK aktivitesi, Normozoospermi, Şiddetli oligozoospermi

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