USE OF VITAMIN D IN CRITICALLY ILL COVİD-19 PATIENTS

Abstract

Aim: Coronavirus 19 disease (COVID-19) is the cause of the pandemic that began in Wuhan, China, in December 2019, characterized by severe pulmonary infection and acute respiratory failure. Vitamin D reduces the risk of infections. This study was aimed to evaluate the effect of vitamine D on acute phase reactants, oxygenation and mortality in critically ill COVID-19 patients.
Methods: Patients were retrospectively analyzed between March-December 2020. Eighty-nine patients were included in the study.
Results: Thirty-three patients(37%) received vitamin D, 56 patients(63%) did not. The median age of the patients was 69 years(33-101). Eleven(12,3%) of 21 patients who underwent invasive mechanical ventilation on the first day at ICU stay received vitamin D in the intensive care unit, 10 patients(11,2%) did not. Over the 14 days, procalcitonin, neutrophil/lymphocite ratio, lactate dehydrogenase, did not change in patients who received vitamin D(p=0,78,p=0,19,p=0,11). There was increase in PaO₂/FiO₂ ratio over 14 days in both groups, however, it was distinctly significant in patients who received vitamin D (p<0,001).
Conclusion: In conclusion, there was no difference in the acute phase reactants, the need for mechanical ventilation, the duration of intensive care, hospitalization, and mortality in COVID-19 patients who received vitamin D compared to those who did not. Improvement in oxygenation was more evident in patients who received vitamin D.

Keywords

• Vitamin D
• Intensive Care
• Covid-19
• pneumonia
• critically illness

USE OF VITAMIN D IN CRITICALLY ILL COVİD-19 PATIENTS

Abstract

Aim: Coronavirus 19 disease (COVID-19) is the cause of the pandemic that began in Wuhan, China, in December 2019, characterized by severe pulmonary infection and acute respiratory failure. Vitamin D reduces the risk of infections. This study was aimed to evaluate the effect of vitamine D on acute phase reactants, oxygenation and mortality in critically ill COVID-19 patients. Methods: Patients were retrospectively analyzed between March-December 2020. Eighty-nine patients were included in the study. Results: Thirty-three patients(37%) received vitamin D, 56 patients(63%) did not. The median age of the patients was 69 years(33-101). Eleven(12,3%) of 21 patients who underwent invasive mechanical ventilation on the first day at ICU stay received vitamin D in the intensive care unit, 10 patients(11,2%) did not. Over the 14 days, procalcitonin, neutrophil/lymphocite ratio, lactate dehydrogenase, did not change in patients who received vitamin D(p=0,78,p=0,19,p=0,11). There was increase in PaO₂/FiO₂ ratio over 14 days in both groups, however, it was distinctly significant in patients who received vitamin D (p<0,001). Conclusion: In conclusion, there was no difference in the acute phase reactants, the need for mechanical ventilation, the duration of intensive care, hospitalization, and mortality in COVID-19 patients who received vitamin D compared to those who did not. Improvement in oxygenation was more evident in patients who received vitamin D.

Keywords

• Vitamin D
• Intensive Care
• Covid-19
• pneumonia
• critically illness

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